Results 41 to 50 of about 31,171 (226)

An 1H NMR study of vinblastine

, 1980
The vicinal coupling constants in the 1H NMR spectrum of vinblastine allow a proposal for the conformation of the catharanthine moiety including the nine-membered ring.The vicinal coupling constants in the 1H NMR spectrum of vinblastine allow a proposal ...
De Bruyn, André8010001443456D9E4C9A-B25E-11E6-B104-2D2FD0AF0289, De Taeye, L, Anteunis, Marc801000029460739A5486-B25E-11E6-B104-2D2FD0AF0289   +2 more
core   +2 more sources

A Simplified Procedure for Indole Alkaloid Extraction from Catharanthus roseus Combined with a Semi-synthetic Production Process for Vinblastine

Molecules, 2007
Dried leaves of Catharanthus roseus were extracted with aqueous acidic 0.1 M solution of HCl. Alkaloid-embonate complexes were obtained as precipitates by treating the extract with an alkaline (NaOH) solution of embonic acid (4,4-methylene-bis-3 ...
Marja-Liisa Riekkola, Aarre Huhtikangas, Tuulikki Seppänen-Laakso, Into Laakso, Arvind Verma   +4 more
doaj   +1 more source

Constructing an External Control Arm Using the French REALYSA Cohort to Replicate Outcomes of a Randomized Trial Arm in Advanced Hodgkin Lymphoma

Clinical Pharmacology &Therapeutics, EarlyView.
External control (EC) arms using routine data can be used as comparators in clinical trials under certain conditions. The objective of this study was to assess the ability of an EC arm to replicate outcomes of a randomized controlled trial (RCT) arm receiving the same treatment strategy in advanced stage classical Hodgkin lymphoma and serve as ...
Olivia Febvey‐Combes, Cédric Rossi, Behrouz Kassai, Tesla Murairi Mirimo, Loïc Chartier, Fanny Cherblanc, Emeline Cugnod, Hervé Ghesquières, Aurélien Belot   +8 more
wiley   +1 more source

Tumor Grade and Mitotic Count Are Prognostic for Dogs with Cutaneous Mast Cell Tumors Treated with Surgery and Adjuvant or Neoadjuvant Vinblastine Chemotherapy

Veterinary Sciences
Objective: Canine cutaneous mast cell tumors (cMCTs) have variable rates of recurrence and metastasis. We evaluated how various prognostic factors affect survival, recurrence, and metastasis in dogs with cMCT who underwent surgery and vinblastine ...
Kristina Anderson, MacKenzie Pellin, Elizabeth Snyder, Dawn Clarke   +3 more
doaj   +1 more source

Vinblastine-Loaded Nanoparticles with Enhanced Tumor-Targeting Efficiency and Decreasing Toxicity: Developed by One-Step Molecular Imprinting Process

, 2019
Molecularly imprinted polymers have exhibited good performance as carriers on drug loading and sustained release. In this paper, vinblastine (VBL)-loaded polymeric nanoparticles (VBL–NPs) were prepared by a one-step molecular imprinting process ...
Ruixuan Liu (6706775), Ruixuan Liu, Yongyan Zhu (6706772), Haoji Huang, Haoji Huang (6706778), Quanhong Zhu (6706781), Quanhong Zhu, Yongyan Zhu   +7 more
core   +1 more source

From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant‐derived active ingredients

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat, Yasin Turanlı, Nihat Kurt, Sefa Gözcü, Emre Tunçel, Hilal Bacanak, Eren Aytekin, Sedat Ünal   +7 more
wiley   +1 more source

Investigation of Dextran-Coated Superparamagnetic Nanoparticles for Targeted Vinblastine Controlled Release, Delivery, Apoptosis Induction, and Gene Expression in Pancreatic Cancer Cells

Molecules, 2020
In the current study, the surface of superparamagnetic iron oxide (SPION) was coated with dextran (DEX), and conjugated with folic acid (FA), to enhance the targeted delivery and uptake of vinblastine (VBL) in PANC-1 pancreatic cancer cells.
Salim Albukhaty, Sharafaldin Al-Musawi, Salih Abdul Mahdi, Ghassan M. Sulaiman, Mona S. Alwahibi, Yaser Hassan Dewir, Dina A. Soliman, Humaira Rizwana   +7 more
doaj   +1 more source

Sickling and Vinblastine.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1983
After incubation of sickle anaemia (SS) erythrocytes for 1 hour at room temperature with Vinblastine (VBL) doses (0.2 mM) far lower than those capable of causing spherostomatocytosis of normal red blood cells (0.6 mM), the percent of erythrocytes which underwent swelling resulted to be overlapping the percentage of cells which showed irreversible ...
RICCI, Giorgio, ZAVAGLI, Giorgio
openaire   +2 more sources

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Microfluidic Synthesis of Vinblastine-Loaded Multifunctional Particles for Magnetically Responsive Controlled Drug Release

Pharmaceutics, 2019
Vinblastine (VBL) is a major chemotherapeutic drug; however, in some cases, it may cause severe side effects in patients with cancer. Designing a novel VBL pharmaceutical formulation is a crucial and emerging concern among researchers for reducing the ...
Keng-Shiang Huang, Chih-Hui Yang, Ya-Chin Wang, Wei-Ting Wang, Yen-Yi Lu   +4 more
doaj   +1 more source