Results 21 to 30 of about 24,123 (191)

Sapogenins isolated from the greater celandine (Chelidonium majus L.) seeds potentiate a therapeutic effect of vinblastine towards murine NK/Ly lymphoma

Біологічні студії, 2012
Two treatment schemes (vinblastine and vinblastin in combination with sapogenin-like substance (SLS) isolated from the greater celandine seeds) were applied towards murine NK/Ly lymphoma, and their therapeutic effects were compared.
M. D. Lootsik, M. M. Lutsyk, R. S. Stoika   +2 more
doaj   +1 more source

CELL CARRIERS AS SYSTEMS OF DELIVERY OF ANTITUMOR DRUGS (REVIEW)

Разработка и регистрация лекарственных средств, 2019
Introduction. Drug delivery systems are defined as systems that deliver the optimal amount of a drug to a target target, increase the effectiveness of treatment, and reduce adverse effects.
O. V. Trineeva, A. J. Halahakoon, A. I. Slivkin   +2 more
doaj   +1 more source

Effects of vinblastine on microvascular anastomosis healing in diabetic rats

Acta Orthopaedica et Traumatologica Turcica, 2020
Objective: Diabetes mellitus and chemotherapy use are well-known factors that can affect success after microvascular repair. Although many studies have investigated each factor individually, no study exists on their combined effect.
Semra Karsidag, Soner Tatlidede, Ugur Tosun, Kemalettin Yildiz, Fevziye Kabukcuoglu, Arzu Akcal   +5 more
doaj   +1 more source

Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism

Pharmacology Research & Perspectives, 2023
Vinblastine (VBL) is a vinca alkaloid‐class cytotoxic chemotherapeutic that causes microtubule disruption and is typically used to treat hematologic malignancies. VBL is characterized by a narrow therapeutic index, with key dose‐limiting toxicities being
Sandra Witta, Keagan P. Collins, Dominique A. Ramirez, Joshua D. Mannheimer, Luke A. Wittenburg, Daniel L. Gustafson   +5 more
doaj   +1 more source

Vinblastine, an anticancer drug, causes constipation and oxidative stress as well as others disruptions in intestinal tract in rat

Toxicology Reports, 2017
The purpose of this study is to examine the gastrointestinal disorders after injection of vinblastine (2 mg kg−1 b.w. i.v.) in rats. Animals were divided into two equal groups: Group 1 was considered as a control group (NaCl, 0.9%).
Kaïs Rtibi, Dhekra Grami, Slimen Selmi, Mohamed Amri, Hichem Sebai, Lamjed Marzouki   +5 more
doaj   +1 more source

Infantile Central Nervous System Juvenile Xanthogranuloma With Somatic CSF1R Mutation Responsive to Imatinib Monotherapy

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Juvenile xanthogranuloma (JXG) of the central nervous system (CNS) is a rare non‐Langerhans cell histiocytosis. CSF1R mutations have been reported for peripheral JXG, but not in CNS JXG. A 3‐month‐old male presented with fever, lymphadenopathy, and macrocephaly with bulging fontanelles.
Sima Vazquez, Kayla Etienne, Long Di, Valerie Martinez‐Torres, Andrew Rosenberg, Sakir H. Gultekin, Aditi Dhir, Bradley Gampel, Heather J. McCrea   +8 more
wiley   +1 more source

A Simplified Procedure for Indole Alkaloid Extraction from Catharanthus roseus Combined with a Semi-synthetic Production Process for Vinblastine

Molecules, 2007
Dried leaves of Catharanthus roseus were extracted with aqueous acidic 0.1 M solution of HCl. Alkaloid-embonate complexes were obtained as precipitates by treating the extract with an alkaline (NaOH) solution of embonic acid (4,4-methylene-bis-3 ...
Marja-Liisa Riekkola, Aarre Huhtikangas, Tuulikki Seppänen-Laakso, Into Laakso, Arvind Verma   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Phenotypic Variability and Anticancer Alkaloid Profiles of Catharanthus roseus Cultivars Grown Under a Vertical Farming System

Plants
Plants are promising biofactories for high-value compounds, and integrating vertical farming (VF) with plant molecular farming (PMF) enhances the efficiency and sustainability of these systems.
Marisa S. C. Lourenço, Victor Freitas, Ep Heuvelink, Susana M. P. Carvalho   +3 more
doaj   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source