Results 11 to 20 of about 24,082 (195)

High Sensitivity ctDNA Analysis Using a Novel Panel and NOIR-SS Technology for Monitoring Advanced Urothelial Carcinoma. [PDF]

Cancer Med
ABSTRACT Advanced urothelial carcinoma (aUC) has a poor prognosis, and real‐time monitoring of treatment response remains clinically challenging. Circulating tumor DNA (ctDNA) has emerged as a promising non‐invasive biomarker that may reflect tumor burden and molecular response.
Danno T, Nakamura S, Taguchi S, Fujii Y, Teshima T, Sato Y, Kawai T, Kobayashi Y, Nagaoka K, Ueda Y, Matoba R, Kakimi K, Kume H.   +12 more
europepmc   +2 more sources

Clinical and immunohistochemical findings of splenic mast cell tumour in a cat: A case report

Veterinární Medicína, 2021
A 6-year-old, spayed, female, domestic shorthair cat presented with a 4-month history of chronic intermittent vomiting and anorexia. The haematologic results indicated moderate anaemia and a circulating mast cell population.
S Lee, Kang MS, Y Jeong, Y Kim, Kwak HH, Choi EW, S Choi, I Park, Chung JY, Choi JH, Ahn JO   +10 more
doaj   +1 more source

A comparison of paclitaxel and vinblastine induced giant cell formation in murine NK/Ly lymphoma

Біологічні студії, 2011
We compared giant cell formation in murine NK/Ly lymphoma under treatment with anticancer drugs – vinblastine or paclitaxel. It was found that vinblastine caused an appearance of bigger cells than paclitaxel did, whereas paclitaxel induced more rapid ...
R. O. Horbay, N. I. Kashchak, R. S. Stoika   +2 more
doaj   +1 more source

A Nonselective Cyclooxygenase Inhibitor Enhances the Activity of Vinblastine in a Naturally-Occurring Canine Model of Invasive Urothelial Carcinoma

Bladder Cancer, 2016
Background: Chemotherapy is expected to remain an important part of invasive urothelial carcinoma (UC) treatment. Strategies to enhance chemotherapy efficacy are needed.
Deborah W. Knapp, Audrey Ruple-Czerniak, José A. Ramos-Vara, James F. Naughton, Christopher M. Fulkerson, Sonia I. Honkisz   +5 more
doaj   +1 more source

Sapogenins isolated from the greater celandine (Chelidonium majus L.) seeds potentiate a therapeutic effect of vinblastine towards murine NK/Ly lymphoma

Біологічні студії, 2012
Two treatment schemes (vinblastine and vinblastin in combination with sapogenin-like substance (SLS) isolated from the greater celandine seeds) were applied towards murine NK/Ly lymphoma, and their therapeutic effects were compared.
M. D. Lootsik, M. M. Lutsyk, R. S. Stoika   +2 more
doaj   +1 more source

Discovery of active site of vinblastine as application of nanotechnology in medicine [PDF]

Nanomedicine Journal, 2014
Objective(s): Vinblastine is antimitotic, anticancer medicine that disturbs normal microtubule formation and favours depolymerisation. Structural study and finding the active site of vinblastine are the targets of this research.
Zahra varmaghani, Majjid Monajjemi, Fatemeh mollaamin   +2 more
doaj  

Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism

Pharmacology Research & Perspectives, 2023
Vinblastine (VBL) is a vinca alkaloid‐class cytotoxic chemotherapeutic that causes microtubule disruption and is typically used to treat hematologic malignancies. VBL is characterized by a narrow therapeutic index, with key dose‐limiting toxicities being
Sandra Witta, Keagan P. Collins, Dominique A. Ramirez, Joshua D. Mannheimer, Luke A. Wittenburg, Daniel L. Gustafson   +5 more
doaj   +1 more source

Tyrosine kinase inhibitors as an alternative treatment in canine mast cell tumor

Frontiers in Veterinary Science, 2023
The current gold standard treatment for canine mast cell tumors (MCT) uses vinblastine sulfate (VBL) as chemotherapy, although tyrosine kinase inhibitors (TKI) have recently been shown to be worthy candidates for treatment.
Yasmin Nascimento Bernardes Coelho, Luiz Ricardo Soldi, Paulo Henrique Rosa da Silva, Caio Melo Mesquita, Luiz Renato Paranhos, Thaísa Reis dos Santos, Marcelo José Barbosa Silva   +6 more
doaj   +1 more source

CELL CARRIERS AS SYSTEMS OF DELIVERY OF ANTITUMOR DRUGS (REVIEW)

Разработка и регистрация лекарственных средств, 2019
Introduction. Drug delivery systems are defined as systems that deliver the optimal amount of a drug to a target target, increase the effectiveness of treatment, and reduce adverse effects.
O. V. Trineeva, A. J. Halahakoon, A. I. Slivkin   +2 more
doaj   +1 more source

Study of Desorbtion and Exemption of Terpeno-indole Alkaloids of Vinkristin and Vinblastin from Erythrocitary Cell Carriers

Разработка и регистрация лекарственных средств, 2019
Introduction. Employees of the Department of Pharmaceutical Chemistry and Pharmaceutical Technology have obtained modified forms of terpino-indole alkaloids (ТIA) and vinbristine (VCR) and vinblastine (VBL) known in the treatment of cancer diseases by ...
O. V. Trineeva, A. D. Khalahakun
doaj   +1 more source