Results 11 to 20 of about 44,757 (227)

Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis [PDF]

, 2009
The aims of the study were to meet the demand of new tubulin antagonists with fewer side effects by characterizing the antiangiogenic properties of the experimental compound spongistatin 1, and to elucidate nonmitotic mechanisms by which tubulin ...
Bruns, Christiane J., Fürst, Robert, Garczarczyk, Dorota, Ischenko, Ivan, Joore, Jos, Rothmeier, Andrea S., Vollmar, Angelika M., Zahler, Stefan   +7 more
core   +1 more source

Genome-wide identification of NAC transcription factors and regulation of monoterpenoid indole alkaloid biosynthesis in Catharanthus roseus

Frontiers in Plant Science, 2023
NAC transcription factors (TFs) are crucial to growth and defense responses in plants. Though NACs have been characterized for their role in several plants, comprehensive information regarding their role in Catharanthus roseus, a perennial ornamental ...
Jawad Ahmed, Jawad Ahmed, Yasar Sajjad, Mansour K. Gatasheh, Khalid Elfaki Ibrahim, Muhammad Huzafa, Sabaz Ali Khan, Chen Situ, Arshad Mehmood Abbasi, Amjad Hassan   +9 more
doaj   +1 more source

A Nonselective Cyclooxygenase Inhibitor Enhances the Activity of Vinblastine in a Naturally-Occurring Canine Model of Invasive Urothelial Carcinoma

Bladder Cancer, 2016
Background: Chemotherapy is expected to remain an important part of invasive urothelial carcinoma (UC) treatment. Strategies to enhance chemotherapy efficacy are needed.
Deborah W. Knapp, Audrey Ruple-Czerniak, José A. Ramos-Vara, James F. Naughton, Christopher M. Fulkerson, Sonia I. Honkisz   +5 more
doaj   +1 more source

Genotoxic mixtures and dissimilar action: Concepts for prediction and assessment [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund. This article is distributed under the terms of the creative commons Attribution license which permits any use, distribution, and reproduction in any medium, provided ...
A Bouslimi, A Elhajouji, Andreas Kortenkamp, AY Kocaman, CI Bliss, D Kirkland, E Hecker, K Drescher, K Hashimoto, K Hashimoto, M Faust, M Fenech, M Honma, M Marinovich, M Scholze, Martin Scholze, MC Berenbaum, MC Berenbaum, National Research Council, P Fowler, R Altenburger, S Ermler, S Loewe, Sibylle Ermler, T Backhaus, T Mosmann, W Slob, WK Lutz, WK Lutz, WK Lutz   +29 more
core   +2 more sources

Imatinib Mesylate for the Treatment of Canine Mast Cell Tumors: Assessment of the Response and Adverse Events in Comparison with the Conventional Therapy with Vinblastine and Prednisone

Cells, 2022
Mast cell tumors (MCTs) are common neoplasms in dogs, and treatments for these diseases include surgery, polychemotherapy and targeted therapy with tyrosine kinase inhibitors.
Thais Rodrigues Macedo, Genilson Fernandes de Queiroz, Thaís Andrade Costa Casagrande, Pâmela Almeida Alexandre, Paulo Eduardo Brandão, Heidge Fukumasu, Samanta Rios Melo, Maria Lucia Zaidan Dagli, Ana Carolina B. C. Fonseca Pinto, Julia Maria Matera   +9 more
doaj   +1 more source

Pulse-Administered Toceranib Phosphate Plus Lomustine for Treatment of Unresectable Mast Cell Tumors in Dogs. [PDF]

, 2015
BackgroundNonresectable mast cell tumors (MCT) in dogs remain a therapeutic challenge, and investigation of novel combination therapies is warranted. Intermittent administration of tyrosine kinase inhibitors (TKI) combined with cytotoxic chemotherapy may
Avery, AC, Axiak-Bechtel, SM, Burton, JH, Clifford, CA, Thamm, DH, Vail, DM, Venable, RO, Williams, LE   +7 more
core   +1 more source

Sapogenins isolated from the greater celandine (Chelidonium majus L.) seeds potentiate a therapeutic effect of vinblastine towards murine NK/Ly lymphoma

Біологічні студії, 2012
Two treatment schemes (vinblastine and vinblastin in combination with sapogenin-like substance (SLS) isolated from the greater celandine seeds) were applied towards murine NK/Ly lymphoma, and their therapeutic effects were compared.
M. D. Lootsik, M. M. Lutsyk, R. S. Stoika   +2 more
doaj   +1 more source

Development of a Cell Suspension Culture System for Promoting Alkaloid and Vinca Alkaloid Biosynthesis Using Endophytic Fungi Isolated from Local Catharanthus roseus

Plants, 2021
Cell and tissue cultures of Catharanthus roseus have been studied extensively as an alternative strategy to improve the production of valuable secondary metabolites. The purpose of this study was to produce C. roseus callus and suspension cell biomass of
Tran My Linh, Nguyen Chi Mai, Pham Thi Hoe, Ninh Thi Ngoc, Phan Thi Hong Thao, Ninh Khac Ban, Nguyen Tuong Van   +6 more
doaj   +1 more source

Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans [PDF]

, 2012
Peer ...
Alberto Delgado, Amieva, Argent, Barrett, Cathy Streutker, Dana J. Philpott, Deepa Raju, Deretic, El-Omar, Emad El Omar, Erdmutte Kunstmann, Esther Galindo–Mata, Franco, Georgina Hold, Gonzalez, Gutierrez, Heidi Mascarenhas, Iwamaru, Jia, Judith Romero–Gallo, Kimura, Kirkegaard, Kuballa, Lapaquette, Levine, Luther, Luther, Mahendra Singh Ramjeet, Maiuri, Mark S. Silverberg, Mathew, Mathew, Mauricio R. Terebiznik, Michal Sibony, Michelle Ang, Mortimore, Moscat, Nicola L. Jones, Ogawa, Ogawa, Orvedahl, Pelayo Correa, Polk, Richard M. Peek, Rioux, Saitoh, Satin, Scott, Seamus Hussey, Stephen E. Girardin, Steven R. Blanke, Tamotsu Yoshimori, Tanida, Terebiznik, Terebiznik, Travassos, Vijay Gupta, Wang, White, Yoshimori, Zheng, Zheng   +61 more
core   +1 more source

Discovery of active site of vinblastine as application of nanotechnology in medicine [PDF]

Nanomedicine Journal, 2014
Objective(s): Vinblastine is antimitotic, anticancer medicine that disturbs normal microtubule formation and favours depolymerisation. Structural study and finding the active site of vinblastine are the targets of this research.
Zahra varmaghani, Majjid Monajjemi, Fatemeh mollaamin   +2 more
doaj