Results 11 to 20 of about 31,171 (226)

Exploring the potential of two Pseudomonas species to produce vincristine from vinblastine via biotransformation

Scientific Reports
A biotransformation pair consisting of vinblastine: vincristine present in the Catharanthus roseus plant is of immense pharmacological significance.
Gauri Srivastava, Ruchika Mittal, Nidhi Srivastava, Deepak Ganjewala   +3 more
doaj   +2 more sources

Paclitaxel induces NM2-dependent cellular contraction through GEF-H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells. [PDF]

Mol Oncol
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Asensio-Juárez G, Pérez-Díaz R, Ramos-Solano H, Garrido-Casado M, Talayero VC, Vicente-Manzanares M.   +5 more
europepmc   +2 more sources

Convolvulus althaeoides as a Potential Natural Source in Cancer Prophylaxis and Treatment: LC-ESI-MS/MS, GC-MS, In Vitro, and In Silico Investigations. [PDF]

Chem Biodivers
n‐hexane and EtOAc fractions of Convolvulus althaeoides aerial parts have potent cytotoxicity, significant antioxidant, and moderate anti‐inflammatory effects. These activities emphasize the potential role of this plant in cancer prophylaxis and treatment.
Hassan AR, El-Dein SN, Korkor AM, Hassan NF, Selim AAMA.   +4 more
europepmc   +2 more sources

STUDY ON ECTOPIC CALCIFICATION IN BONE MARROW OF RAT TIBIA CAUSED BY VINBLASTINE [PDF]

, 1986
Contact microradiographic study and histological study were performed to investigate the sequential changes in the bone marrow after a large dose of vinblastine or colchicine administration.
Yukihiko, TAMURA
core   +1 more source

Vinblastine sensitivity of leukaemic lymphoblasts modulated by serum lipid [PDF]

, 1989
The high-resolution proton magnetic resonance spectrum of leukaemic lymphoblasts is characteristic of neutral lipid in an isotropic environment. When such lymphoblasts are selected for resistance to the anticancer drug vinblastine, the intensity of this ...
Tripp, Edith, Carolyn E. Mountford, Mountford, Carolyn E., Mountford, CE, Philip G. Williams, Wright, Lesley C., Wright, LC, Holmes, KT, Edith Tripp, Marlen Dyne, George L. May, Dyne, M, Williams, PG, Dyne, Marlen, Tripp, E, Lesley C. Wright, Mountford, Carolyn, Kerry T. Holmes, Williams, Philip G., May, George L., Holmes, Kerry T., May, GL   +21 more
core   +1 more source

Tyrosine kinase inhibitors as an alternative treatment in canine mast cell tumor

Frontiers in Veterinary Science, 2023
The current gold standard treatment for canine mast cell tumors (MCT) uses vinblastine sulfate (VBL) as chemotherapy, although tyrosine kinase inhibitors (TKI) have recently been shown to be worthy candidates for treatment.
Yasmin Nascimento Bernardes Coelho, Luiz Ricardo Soldi, Paulo Henrique Rosa da Silva, Caio Melo Mesquita, Luiz Renato Paranhos, Thaísa Reis dos Santos, Marcelo José Barbosa Silva   +6 more
doaj   +1 more source

A Nonselective Cyclooxygenase Inhibitor Enhances the Activity of Vinblastine in a Naturally-Occurring Canine Model of Invasive Urothelial Carcinoma

Bladder Cancer, 2016
Background: Chemotherapy is expected to remain an important part of invasive urothelial carcinoma (UC) treatment. Strategies to enhance chemotherapy efficacy are needed.
Deborah W. Knapp, Audrey Ruple-Czerniak, José A. Ramos-Vara, James F. Naughton, Christopher M. Fulkerson, Sonia I. Honkisz   +5 more
doaj   +1 more source

Sapogenins isolated from the greater celandine (Chelidonium majus L.) seeds potentiate a therapeutic effect of vinblastine towards murine NK/Ly lymphoma

Біологічні студії, 2012
Two treatment schemes (vinblastine and vinblastin in combination with sapogenin-like substance (SLS) isolated from the greater celandine seeds) were applied towards murine NK/Ly lymphoma, and their therapeutic effects were compared.
M. D. Lootsik, M. M. Lutsyk, R. S. Stoika   +2 more
doaj   +1 more source

Genome-wide identification of NAC transcription factors and regulation of monoterpenoid indole alkaloid biosynthesis in Catharanthus roseus

Frontiers in Plant Science, 2023
NAC transcription factors (TFs) are crucial to growth and defense responses in plants. Though NACs have been characterized for their role in several plants, comprehensive information regarding their role in Catharanthus roseus, a perennial ornamental ...
Jawad Ahmed, Jawad Ahmed, Yasar Sajjad, Mansour K. Gatasheh, Khalid Elfaki Ibrahim, Muhammad Huzafa, Sabaz Ali Khan, Chen Situ, Arshad Mehmood Abbasi, Amjad Hassan   +9 more
doaj   +1 more source

Imatinib Mesylate for the Treatment of Canine Mast Cell Tumors: Assessment of the Response and Adverse Events in Comparison with the Conventional Therapy with Vinblastine and Prednisone

Cells, 2022
Mast cell tumors (MCTs) are common neoplasms in dogs, and treatments for these diseases include surgery, polychemotherapy and targeted therapy with tyrosine kinase inhibitors.
Thais Rodrigues Macedo, Genilson Fernandes de Queiroz, Thaís Andrade Costa Casagrande, Pâmela Almeida Alexandre, Paulo Eduardo Brandão, Heidge Fukumasu, Samanta Rios Melo, Maria Lucia Zaidan Dagli, Ana Carolina B. C. Fonseca Pinto, Julia Maria Matera   +9 more
doaj   +1 more source