Results 31 to 40 of about 31,171 (226)

Vinblastine monotherapy induction prior to radiotherapy for patients with intracranial germinoma during the COVID-19 pandemic. [PDF]

, 2021
BACKGROUND: Patients with localized intracranial germinoma have excellent survival. Reducing treatment burden and long-term sequelae is a priority. Intensive inpatient chemotherapy (e.g., carboPEI = carboplatin/etoposide/ifosfamide) has been effectively ...

core   +2 more sources

Effects of foliar application of tryptophan on physiological and biochemical traits of Madagascar periwinkle (Catharanthus roseus L.) under different drought stress levels [PDF]

تنش های محیطی در علوم زراعی
IntroductionMedicinal plants are valuable sources of bioactive compounds with therapeutic properties and play an important role in the pharmaceutical and medical industries.
Farshid Yousefi, Alireza Abdali Mashhadhi, Amin Lotfi Jalalabadi, Alireza Shafeinia, Saeed Jalily, Narges Soltani   +5 more
doaj   +1 more source

Potent Vinblastine C20′ Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line

, 2016
A series of disubstituted C20′-urea derivatives of vinblastine were prepared from 20′-aminovinblastine that was made accessible through a unique Fe­(III)/NaBH4-mediated alkene functionalization reaction of anhydrovinblastine.
Katerina Otrubova (1307904), Dale L. Boger (1306542), Timothy J. Barker (1681669), Katharine K. Duncan (1897090)   +3 more
core   +1 more source

Review of abiotic and biotic elicitors’ roles in secondary metabolites biosynthesis of periwinkle (Catharanthus roseus (Linn.) G. Don)

Journal of Medicinal Plants, 2020
Background: Based on recent statistical survey, the cancer is the third important factor in Iran mortality. Vinblastine and vincristine alkaloids are dominantly biosynthesized in the aerial parts of periwinkle, broadly applied for cancer treatment ...
Saleh Amiri, Reza Fotovat, Bahman Panahi, Alireza Tarinezhad, Seyyed Abolghasem Mohammadi   +4 more
doaj  

Effects of vinblastine on microvascular anastomosis healing in diabetic rats

Acta Orthopaedica et Traumatologica Turcica, 2020
Objective: Diabetes mellitus and chemotherapy use are well-known factors that can affect success after microvascular repair. Although many studies have investigated each factor individually, no study exists on their combined effect.
Semra Karsidag, Soner Tatlidede, Ugur Tosun, Kemalettin Yildiz, Fevziye Kabukcuoglu, Arzu Akcal   +5 more
doaj   +1 more source

Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism

Pharmacology Research & Perspectives, 2023
Vinblastine (VBL) is a vinca alkaloid‐class cytotoxic chemotherapeutic that causes microtubule disruption and is typically used to treat hematologic malignancies. VBL is characterized by a narrow therapeutic index, with key dose‐limiting toxicities being
Sandra Witta, Keagan P. Collins, Dominique A. Ramirez, Joshua D. Mannheimer, Luke A. Wittenburg, Daniel L. Gustafson   +5 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Vinblastine, an anticancer drug, causes constipation and oxidative stress as well as others disruptions in intestinal tract in rat

Toxicology Reports, 2017
The purpose of this study is to examine the gastrointestinal disorders after injection of vinblastine (2 mg kg−1 b.w. i.v.) in rats. Animals were divided into two equal groups: Group 1 was considered as a control group (NaCl, 0.9%).
Kaïs Rtibi, Dhekra Grami, Slimen Selmi, Mohamed Amri, Hichem Sebai, Lamjed Marzouki   +5 more
doaj   +1 more source

Dissociation of tubulin assembly-inhibiting and aggregation-promoting activities by a vinblastine derivative [PDF]

, 1997
A fluorescent vinblastine analogue, vinblastine-4′-anthranilate (Antvin), that binds to the vinca site on tubulin, inhibits tubulin assembly but does not lead to spiral or other large aggregate formation at concentrations up to 1.6 mM.
J. Wolff, Rai, Sadananda S., Sadananda S. Rai, Wolff, J.   +3 more
core   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source