Results 31 to 40 of about 2,672,670 (309)

Viral sensors: diversity in pathogen recognition [PDF]

Immunological Reviews, 2008
Summary:  Innate sensors of viral infection detect viral products and initiate the signal cascades that lead to the antiviral response. Several proteins have been identified to play a role in this process, mostly members of the Toll‐like receptor and retinoic acid‐inducible gene I‐like receptor families.
Stephen A, McCartney, Marco, Colonna
openaire   +2 more sources

Extended Evaluation of Viral Diversity in Lake Baikal through Metagenomics

Microorganisms, 2021
Lake Baikal is a unique oligotrophic freshwater lake with unusually cold conditions and amazing biological diversity. Studies of the lake’s viral communities have begun recently, and their full diversity is not elucidated yet.
T. Butina, Yurij S. Bukin, I. Petrushin, A. Tupikin, Marsel R Kabilov, S. Belikov   +5 more
semanticscholar   +1 more source

Stable distinct core eukaryotic viromes in different mosquito species from Guadeloupe, using single mosquito viral metagenomics

Microbiome, 2019
Background Mosquitoes are the most important invertebrate viral vectors in humans and harbor a high diversity of understudied viruses, which has been shown in many mosquito virome studies in recent years.
Chenyan Shi, Leen Beller, Ward Deboutte, Kwe Claude Yinda, Leen Delang, Anubis Vega-Rúa, Anna-Bella Failloux, Jelle Matthijnssens   +7 more
doaj   +1 more source

Optimized quantification of intra-host viral diversity in SARS-CoV-2 and influenza virus sequence data

bioRxiv, 2021
High error rates of viral RNA-dependent RNA polymerases lead to diverse intra-host viral populations during infection. Errors made during replication that are not strongly deleterious to the virus can lead to the generation of minority variants. However,
A. Roder, K. E. Johnson, M. Knoll, M. Khalfan, B. Wang, S. Schultz‐Cherry, S. Banakis, A. Kreitman, C. Mederos, J. Youn, R. Mercado, W. Wang, M. Chung, D. Ruchnewitz, M. Samanovic, M. Mulligan, M. Lässig, M. Luksza, S. Das, D. Gresham, E. Ghedin   +20 more
semanticscholar   +1 more source

Viral Diversity in Asthma

Immunology and Allergy Clinics of North America, 2010
Asthma exacerbations are precipitated primarily by respiratory virus infection and frequently require immediate medical intervention. Studies of childhood and adult asthma have implicated a wide variety of respiratory viruses in exacerbations. By focusing on both RNA and DNA respiratory viruses and some newly identified viruses, this review illustrates
McErlean, Peter, Greiman, Alyssa, Favoreto, Silvio, Avila, Pedro C.   +3 more
openaire   +2 more sources

Duck gut viral metagenome analysis captures snapshot of viral diversity [PDF]

Gut Pathogens, 2016
Ducks (Anas platyrhynchos) an economically important waterfowl for meat, eggs and feathers; is also a natural reservoir for influenza A viruses. The emergence of novel viruses is attributed to the status of co-existence of multiple types and subtypes of viruses in the reservoir hosts.
Fawaz, Mohammed, Vijayakumar, Periyasamy, Mishra, Anamika, Gandhale, Pradeep N., Dutta, Rupam, Kamble, Nitin M., Sudhakar, Shashi B., Roychoudhary, Parimal, Kumar, Himanshu, Kulkarni, Diwakar D., Raut, Ashwin Ashok   +10 more
openaire   +2 more sources

Diverse viral proteases activate the NLRP1 inflammasome [PDF]

eLife, 2020
The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting in degradation of the N-terminal domains of NLRP1B and liberation of the bioactive C-terminal domain, which includes the caspase activation and ...
Brian V Tsu, Christopher Beierschmitt, Andrew P Ryan, Rimjhim Agarwal, Patrick S Mitchell, Matthew D Daugherty   +5 more
openaire   +4 more sources

RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature

Microbiology Spectrum, 2022
The virus-encoded RNA-dependent RNA polymerase (RdRp) is responsible for viral replication, and its fidelity is closely related to viral diversity, pathogenesis, virulence, and fitness.
Shuyi Chen, Jiqin Wu, Xiaofeng Yang, Qiuli Sun, Su Liu, Farooq Rashid, Emmanuel Enoch Dzakah, Haiying Wang, Jufang Wang, Peng Gong, Shixing Tang   +10 more
doaj   +1 more source

Assessing the Diversity of Endogenous Viruses Throughout Ant Genomes

Frontiers in Microbiology, 2019
Endogenous viral elements (EVEs) can play a significant role in the evolution of their hosts and have been identified in animals, plants, and fungi.
Peter J. Flynn, Peter J. Flynn, Corrie S. Moreau, Corrie S. Moreau   +3 more
doaj   +1 more source

Metagenomic Insight into the Microbiome and Virome Associated with Aedes aegypti Mosquitoes in Manado (North Sulawesi, Indonesia)

Infectious Disease Reports, 2023
The aim of this study was to investigate the microbial diversity encompassing bacteria, fungi, and viruses within the composite microbial community associated with Aedes aegypti mosquitoes in Manado, Indonesia, using a whole-genome shotgun metagenomics ...
Janno Berty Bradly Bernadus, Jantje Pelealu, Grace Debbie Kandou, Arthur Gehart Pinaria, Juliet Merry Eva Mamahit, Trina Ekawati Tallei   +5 more
doaj   +1 more source