Results 81 to 90 of about 447,313 (350)

Viral quasispecies profiles as the result of the interplay of competition and cooperation [PDF]

, 2010
Viral quasispecies can be regarded as a swarm of genetically related mutants or a quasispecies (QS). A common formalism to approach QS is the replicator-mutator equation (RME).
Arbiza, Juan, Fort, Hugo, Mirazo, Santiago   +2 more
core   +3 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Viral diversity of Junín virus field strains

Virus Research, 2011
The Argentine Hemorrhagic Fever, an endemic disease present in a much of Argentina, is caused by the Junín virus (JUNV). Currently, there are sequences available from several strains of this virus, like those belonging to the vaccine lineage (XJ13, XJ#44 and Candid#1), as well as MC2 (rodent isolate) and IV4454 (human isolate).
Goñi, Sandra Elizabeth, Stephan, Betina Inés, Iserte, Javier Alonso, Contigiani de Minio, Marta Silvia, Lozano, Mario Enrique, Antonio Tenorio   +5 more
openaire   +3 more sources

The diversity of endogenous viral elements in insects

Current Opinion in Insect Science, 2022
We provide an overview of the currently known diversity of viral sequences integrated into insect genomes. Such endogenous viral elements (EVE) have so far been annotated in at least eight insect orders and can be assigned to at least three families of large double-stranded (ds) DNA viruses, at least 22 families of RNA viruses, and three families of ...
Gilbert, Clément, Belliardo, Carole
openaire   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Arctic an unexpected hotspot for viral diversity [PDF]

Nature Reviews Microbiology, 2019
This study reports the findings of a large global survey of the ecological diversity of viruses in the oceans and shows that the Arctic ocean is an unexpected hotspot for viral diversity.
openaire   +2 more sources

Evolutionary Diversity of Bat Rabies Virus in São Paulo State, Brazil

Viruses
The history of the rabies virus dates back four millennia, with the virus being considered by many to be the first known transmitted between animals and humans.
Luzia H. Queiroz, Angélica C. A. Campos, Marissol C. Lopes, Elenice M. S. Cunha, Avelino Albas, Cristiano de Carvalho, Wagner A. Pedro, Eduardo C. Silva, Monique S. Lot, Sandra V. Inácio, Danielle B. Araújo, Marielton P. Cunha, Edison L. Durigon, Luiz Gustavo B. Góes, Silvana R. Favoretto   +14 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Dicer-2 Processes Diverse Viral RNA Species

PLoS ONE, 2013
RNA silencing pathways play critical roles in gene regulation, virus infection, and transposon control. RNA interference (RNAi) is mediated by small interfering RNAs (siRNAs), which are liberated from double-stranded (ds)RNA precursors by Dicer and guide the RNA-induced silencing complex (RISC) to targets.
Sabin, L. R., Zheng, Q., Thekkat, P., Yang, J., Hannon, G. J., Gregory, B. D., Tudor, M., Cherry, S.   +7 more
openaire   +6 more sources

Characterization of viral diversity in wild marmot blood from the Qinghai–Tibet Plateau

Frontiers in Microbiology
IntroductionThis study aimed to characterize the viral diversity in the blood of marmots in the Qinghai-Tibet Plateau region, to assess their role as potential viral reservoirs and evaluate the potential implications for wildlife and human health ...
Haisheng Wu, Haisheng Wu, Xiaojie Jiang, Yuan Xi, Songyi Ning, Hailian Wu, Wenyuan Xin, Wenxuan Peng, Shengjun Wang, Wen Zhang   +9 more
doaj   +1 more source