Opposing fates: a bipolar cellular model for FMDV replication shaped by <sup>12</sup>C<sup>6+</sup>heavy-ion mutagenesis. [PDF]
Song X +6 more
europepmc +1 more source
Tearing down the house of mosquito-transmitted viruses. [PDF]
Pandey S, Gack MU.
europepmc +1 more source
Untapped microbial factories for next-generation therapeutics: Endophytic fungi of medicinal plants. [PDF]
Nagib AM +3 more
europepmc +1 more source
Host cytoskeleton and membrane network remodeling in the regulation of viral replication. [PDF]
Gao X, Chen X, Yu L, Zhao S, Jiu Y.
europepmc +1 more source
Liquid-liquid phase separation at the frontline of plant-pathogen battles. [PDF]
Zou J +6 more
europepmc +1 more source
Virus factories: associations of cell organelles for viral replication and morphogenesis [PDF]
AbstractGenome replication and assembly of viruses often takes place in specific intracellular compartments where viral components concentrate, thereby increasing the efficiency of the processes. For a number of viruses the formation of ‘factories’ has been described, which consist of perinuclear or cytoplasmic foci that mostly exclude host proteins ...
Rocio Arranz +2 more
exaly +4 more sources
Capping pores of alphavirus nsP1 gate membranous viral replication factories [PDF]
Positive-sense single-stranded RNA viruses, such as coronaviruses, flaviviruses and alphaviruses, carry out transcription and replication inside virus-induced membranous organelles within host cells1-7. The remodelling of the host-cell membranes for the formation of these organelles is coupled to the membrane association of viral replication complexes ...
Rocio Arranz +2 more
exaly +6 more sources
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Shedding light on reovirus assembly—Multimodal imaging of viral factories
Advances in Virus Research, 2023Avian (ortho)reovirus (ARV), which belongs to Reoviridae family, is a major domestic fowl pathogen and is the causative agent of viral tenosynovitis and chronic respiratory disease in chicken. ARV replicates within cytoplasmic inclusions, so-called viral factories, that form by phase separation and thus belong to a wider class of biological condensates.
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Senescent cell: the ‘factory of viral amplification’
Trends in Microbiology, 2023It has been demonstrated that reactivation of endogenous retroviruses (ERVs), the remnants of ancient retroviral infection, participate in various physiological and pathological conditions. Liu et al. recently showed us very interesting findings that aberrant expression of ERVs, induced by epigenetic alterations, accelerates cellular senescence.
Qiang Chen, Wei Mo
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Cytosolic viral factories (VFs) of mammalian orthoreovirus (MRV) are sites for viral genome replication and assembly of virus progeny. Despite advancements in reverse genetics, the formation and dynamics of VFs still need to be clarified. MRV exploits host cytoskeletal components like microtubules (MTs) throughout its life cycle, including cell entry ...
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