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Molten globule driven and self-downmodulated phase separation of a viral factory scaffold
Journal of Molecular Biology, 2023Viral factories of liquid-like nature host transcription and replication in most viruses. The syncytial respiratory virus factories include gene function proteins, brought together by the phosphoprotein (P) RNA polymerase cofactor, present across non-segmented negative stranded RNA viruses.
Mariano Salgueiro +11 more
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Virology, 2017 Vaccinia virus (VACV), a member of the Poxviridae family, uses cytoplasmic factories for its replication. Recent studies indicated that VACV infection requires a set of nucleoporins. However, how the nucleoporins contribute to viral life cycle remains unclear.
Jomon Joseph +2 more
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Nucleocapsid condensation drives Ebola viral factory maturation and dispersion
2023Summary Replication and genome encapsidation of many negative-sense RNA viruses take place in virus-induced membrane-less organelles termed viral factories (VFs). While liquid properties of VFs are believed to control the transition from genome replication to encapsidation, the nucleocapsid assembly, VF maturation and
Melina Vallbracht +8 more
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Virology, 2018 Mammalian reovirus viral factories (VFs) form filamentous or globular structures depending on the viral strain. In this study, we attempt to characterize the dynamics of both filamentous and globular VFs. Here, we present evidence demonstrating that globular VFs are dynamic entities coalescing between them, thereby gaining in size and concomitantly ...
Mathias Ackermann +2 more
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A glimpse inside the viral factory
Die räumliche Trennung von Transkription und Translation ist eines der charakteristischen Merkmale von Eukaryoten, das durch den Zellkern ermöglicht wird. In den letzten Jahren wurden jedoch virale Strukturen beschrieben, die funktionelle und strukturelle Ähnlichkeiten mit dem eukaryotischen Zellkern aufweisen, und für die eine räumliche Trennung von ...openaire +1 more source
[Virus-induced compartimentalization: aggresomes, cytoplasmic inclusions and viral factories].
Virologie (Montrouge, France)Some viruses induce, in the infected cells, the formation of cytoplasmic inclusions that are known to contain viral proteins. These viral inclusions that share some characteristics of aggresomes have been considered as sideproducts of the infectious process without any role and resulting from the accumulation and aggregation of large quantities of ...
Danielle, Blondel +3 more
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The Next Generation of Cell Factories for Viral Vector Production
Genetic Engineering & Biotechnology News, 2021openaire +1 more source