Results 101 to 110 of about 254,896 (222)

Akabane virus nonstructural protein NSm regulates viral growth and pathogenicity in a mouse model

Journal of Veterinary Medical Science, 2016
The biological function of a nonstructural protein, NSm, of Akabane virus (AKAV) is unknown. In this study, we generated a series of NSm deletion mutant viruses by reverse genetics and compared their phenotypes. The mutant in which the NSm coding region was almost completely deleted could not be rescued, suggesting that NSm plays a role in virus ...
ISHIHARA, Yukari, SHIODA, Chieko, BANGPHOOMI, Norasuthi, SUGIURA, Keita, SAEKI, Kohei, TSUDA, Shumpei, IWANAGA, Tatsuya, TAKENAKA-UEMA, Akiko, KATO, Kentaro, MURAKAMI, Shin, UCHIDA, Kazuyuki, AKASHI, Hiroomi, HORIMOTO, Taisuke   +12 more
openaire   +3 more sources

PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins

Science Signaling, 2018
Interferon stimulates the ADP-ribosylation–dependent degradation of nonstructural Zika virus proteins necessary for viral replication. Ribosylation restricts infection Type I interferon signaling drives the expression of hundreds of interferon-stimulated
Lili Li, Hui Zhao, Ping Liu, Chunfeng Li, Natalie Quanquin, Xue Ji, Nina Sun, Peishuang Du, C. Qin, Ning Lu, G. Cheng   +10 more
semanticscholar   +1 more source

Nonstructural 5A Protein of Hepatitis C Virus Interacts with Pyruvate Carboxylase and Modulates Viral Propagation

PLoS ONE, 2013
Hepatitis C virus (HCV) is highly dependent on cellular factors for its own propagation. By employing tandem affinity purification method, we identified pyruvate carboxylase (PC) as a cellular partner for NS5A protein. NS5A interacted with PC through the N-terminal region of NS5A and the biotin carboxylase domain of PC.
Yim, Seung-Ae, Lim, Yun-Sook, Kim, Jong-Wook, Hwang, Soon B.   +3 more
openaire   +5 more sources

The multifaceted interactions between Newcastle disease virus proteins and host proteins: a systematic review

Virulence
Newcastle disease virus (NDV) typically induces severe illness in poultry and results in significant economic losses for the worldwide poultry sector. NDV, an RNA virus with a single-stranded negative-sense genome, is susceptible to mutation and immune ...
Xiaolong Lu, Xiaoquan Wang, Xiufan Liu, Xiaowen Liu   +3 more
doaj   +1 more source

Direct Interaction between Two Viral Proteins, the Nonstructural Protein 2CATPase and the Capsid Protein VP3, Is Required for Enterovirus Morphogenesis

PLoS Pathogens, 2010
In spite of decades-long studies, the mechanism of morphogenesis of plus-stranded RNA viruses belonging to the genus Enterovirus of Picornaviridae, including poliovirus (PV), is not understood.
Yuxiang. Liu, Chunling Wang, S. Mueller, A. Paul, E. Wimmer, P. Jiang   +5 more
semanticscholar   +1 more source

MicroRNA-like viral small RNA from porcine reproductive and respiratory syndrome virus negatively regulates viral replication by targeting the viral nonstructural protein 2

Oncotarget, 2016
Many viruses encode microRNAs (miRNAs) that are small non-coding single-stranded RNAs which play critical roles in virus-host interactions. Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically impactful viruses in the swine industry.
Li, Na, Yan, Yunhuan, Zhang, Angke, Gao, Jiming, Zhang, Chong, Wang, Xue, Hou, Gaopeng, Zhang, Gaiping, Jia, Jinbu, Zhou, En-Min, Xiao, Shuqi   +10 more
openaire   +3 more sources

Exploring the genetic basis of Newcastle disease virus in chickens: a comprehensive review

Frontiers in Immunology
Newcastle disease (ND) is one of the most serious viral diseases affecting chickens and is caused by Newcastle disease virus (NDV), an avian paramyxovirus serotype-1.
Haile Berihulay, Haile Berihulay, Wei Luo, Ainong Lao, Jian Ji, Manshan Cai, Dingming Shu, Chenglong Luo   +7 more
doaj   +1 more source

Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1

Scientific Reports
Dengue is a mosquito-borne disease caused by dengue virus (DENV) infection, which remains a major public health concern worldwide owing to the lack of specific treatments or antiviral drugs available. This study investigated the potential repurposing of domperidone, an antiemetic and gastrokinetic agent, to control DENV infection.
Nuttapong Kaewjiw, Thanawat Thaingtamtanha, Damini Mehra, Wanida Chawnawa, Tanapan Prommool, Chunya Puttikhunt, Adisak Songjaeng, Kessiri Kongmanas, Panisadee Avirutnan, Prasit Luangaram, Chatchawan Srisawat, Sittiruk Roytrakul, Stephan A. Bäurle, Sansanee Noisakran   +13 more
openaire   +3 more sources

Aptamer as a therapeutic agent for dengue infections

Virology Journal
Dengue virus (DENV) poses a significant global health burden, with current treatments being limited and primarily supportive. Aptamers are an emerging class of molecular recognition elements that are cheaper, less immunogenic and have no batch-to-batch ...
Nur Aida Laili Mislan, Citartan Marimuthu, Amir Muhaimin Akmal Shukri, Jeyanthi Suppiah, Rozainanee Mohd Zain, Fadzilah Mohd Nor, Seok Mui Wang   +6 more
doaj   +1 more source

Spontaneous HCV clearance: an association with gender, age, viral genotypes, infection transmission routes, and markers of HBV and HIV

Терапевтический архив, 2010
Aim. To determine the rate of spontaneous recovery depending on gender, age, prior icteric hepatitis, infection transmission routes, HCV genotype, markers of HBV and HIV. Subjects and methods. A humoral immunity response to core antigen and nonstructural
Sergey Valer'evich Fedorchenko, T L Martynovich, O V Lyashok, Zh A Karyuk, V I Yanchenko, S V Fedorchenko, T L Martynovich, O V Lyashok, Zh A Karyuk, V I Yanchenko   +9 more
doaj