Results 141 to 150 of about 1,527,964 (244)

Oral microbiome and homeostatic regulation of periodontal health: From dysbiosis to precision intervention

VIEW, EarlyView.
Periodontal homeostasis is maintained by coordinated interactions between the oral microbiome and host. Dysbiosis disrupts this ecological balance and contributes to periodontal disease, whereas multi‐omics, artificial intelligence, and microbiome‐based interventions provide emerging opportunities for precision diagnosis, ecological restoration, and ...
Xu Liu, Lei Meng, Wenzhu Song, Peiyu Wang, Bin Liu, Shihui Liu, Qi He, Bing Sun, Wanheng Li, Zhiwei Guan, Rui Dong, Qiang Feng   +11 more
wiley   +1 more source

Impact of Specific Pattern Mutations on Plaque Formation and Attenuation Properties of Dengue Virus Serotype 3. [PDF]

Adv Virol
Sun-Arlee P, Punyahathaikul S, Rodpai E, Ketsuwan K, Wanlayaporn D, Ruangdachsuwan S, Komaikul J, Jaimipuk T, Juntarapornchai S, Boonarkart C, Jongkaewwattana A, Yoksan S, Auewarakul P, Masrinoul P.   +13 more
europepmc   +1 more source

Systemic Treatment of Psoriasis: Current Evidence on Efficacy and Safety

The Journal of Dermatology, EarlyView.
ABSTRACT Systemic treatments for moderate‐to‐severe plaque psoriasis have been advanced from broad immunosuppressants up to agents more selectively targeting cytokines, cytokine receptors, or intracellular signaling. The current systemic treatments mainly consist of conventional systemic agents, biologics targeting tumor necrosis factor (TNF)‐α ...
Teppei Hagino, Naoko Kanda
wiley   +1 more source

Synergistic Effect of Ambient Ozone, Relative Humidity, and Temperature on Epidemic Patterns of Influenza: A Hypothesis and Its Verification

Microbiology and Immunology, EarlyView.
ABSTRACT The mechanisms underlying seasonal patterns in influenza epidemics have long been an enigma. Our laboratory study revealed that ambient ozone significantly inactivates airborne influenza viruses synergistically with higher relative humidity and temperature.
Hidekazu Nishimura, Soichiro Sakata, Julian W. Tang, Suguru Ohmiya, Masanori Katsumi, Takahiro Yokoyama   +5 more
wiley   +1 more source

Solanaceae-Derived Spirostane Saponins Inhibit Dengue Virus Replication and Viral Protein Expression and Exhibit Activity Against Multiple Arboviruses. [PDF]

Drug Dev Res
Jimenez-Posada EV, Mosquera-Martínez OM, Robledo SM, Durango D, Quiñones W, Vizcaíno-Páez S, Martinez-Gutierrez M.   +6 more
europepmc   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

Herpesviruses hijack ISGylation to promote viral capsid assembly. [PDF]

Sci Adv
Li S, Feng S, Liu Y, Qin C, Zhang J, Saito T, Xie X, Fu W, Wang R, Zheng Y, Shu Z, Yeh W, Sasaki S, Tjokro N, Chen L, Munger J, Yuan W, Jung J, Chen C, Feng P.   +19 more
europepmc   +1 more source

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Eugenol-Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights. [PDF]

J Med Virol
Reis ACC, Silva ALSD, Portruneli C, Silva AVP, Braga SFP, Lapa IR, Souza TB, Franco LL, Carvalho DT, Brandão GC.   +9 more
europepmc   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source