Results 161 to 170 of about 1,527,964 (244)

Revisiting endothelial tropism of SARS-CoV-2 using a cell-specific hACE2 mouse model. [PDF]

Microbiol Spectr
Lameire S, Debeuf N, Deckers J, De Wolf C, Vanheerswynghels M, Toussaint W, De Vlieger L, Van Hoecke L, Bruggeman A, De Cae S, Schepens B, Vanhee S, Lambrecht BN.   +12 more
europepmc   +1 more source

A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral particle release and cytopathogenicity. [PDF]

PLoS Pathog
Manuelyan I, Schmoker AM, Yount BL, Eisenhauer P, Keller JI, Gold C, Terino D, Ziegler CM, Alexander J, Hutchinson E, Bhella D, Syme CD, Widman DG, Heise MT, Baric RS, Ballif BA, Botten JW.   +16 more
europepmc   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

TRPV4-mediated calcium influx contributes temperature-dependent SARS-CoV-2 replication. [PDF]

PLoS Pathog
Kobayashi M, Abe H, Sugihara H, Kobayashi N, Omori S, Yamada Y, Ichinohe T.   +6 more
europepmc   +1 more source

Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

The FEBS Journal, EarlyView.
Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester, Owen Leitzel, Samantha Golf, Chelsea M. Phillips, Michael J. Zeitz, Rahul Pandit, Elizabeth Wash, Jenna V. Donohue, Elizabeth A. Istre, James W. Smyth, Samy Lamouille, Stefanie Robel   +11 more
wiley   +1 more source

Small molecule inhibition of the mitochondrial lipid transfer protein STARD7 attenuates influenza viral replication. [PDF]

PLoS Pathog
Sharma S, Khatun O, Adonis J, You S, Hartenbower K, Singh VA, Shaabani N, De S, Matsuo ER, Sattler RY, Covel JA, White KM, Martin-Sancho L, Bakowski MA, Mendonsa DJ, Mehta A, Yassir NS, Olson SH, Matsunaga N, García-Sastre A, Bollong MJ, Farhat NA, Shaw ML, Chanda SK.   +23 more
europepmc   +1 more source

A guide to the ecological limitations of phage therapy of bacterial biofilms: Is what's best for the phage best for the physician?

The FEBS Journal, EarlyView.
Bacteriophages—viruses that kill bacteria—are promising weapons against bacterial biofilms: sessile communities notoriously resistant to antibiotics. Yet phages evolved not so much to eradicate bacteria as to obtain new bacteria to infect. That goal, however, may conflict with the physician's objective of complete bacterial clearance.
Stephen T. Abedon
wiley   +1 more source

Luciferase unleashed: Lighting the path to vaccine approval using a novel high-throughput chikungunya virus neutralization assay. [PDF]

PLoS Negl Trop Dis
Mendy J, Bedell L, Tindale LC, Richardson JS, Li N, Fontebasso Y, Pierson TC, Gottlieb K, Vang L.   +8 more
europepmc   +1 more source

Cutaneous lymphomas – an update

Histopathology, EarlyView.
Primary cutaneous lymphomas and lymphoproliferative disorders are defined by integrated clinical, histopathological, immunophenotypic and genetic features as diagnostic criteria also in the 5th edition of the WHO classification of haematolymphoid tumors.
Werner Kempf, Christina Mitteldorf
wiley   +1 more source

Inferring single-cell heterogeneity of bacteriophage lysis-associated life-history traits from population-scale dynamics. [PDF]

Sci Adv
Dominguez-Mirazo M, Tahan R, Kirzner S, Lindell D, Weitz JS.   +4 more
europepmc   +1 more source