Results 151 to 160 of about 84,952 (272)

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

<i>Phellodendron amurense</i> Leaf Extract Inhibits Rhabdovirus Infection by Targeting Early Stages of Viral Entry. [PDF]

Pathogens
Kim SY, Lee TK, Choi TJ.
europepmc   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

VP1-141 is a determinant of a Vero cell-adapted Coxsackievirus A10 for vaccine development. [PDF]

PLoS Negl Trop Dis
Chen CH, Fang CY, Shen YS, Wang JR, Wu SC, Liu CC.   +5 more
europepmc   +1 more source

SIEDY Diagnostic Accuracy in Assessing Erectile Dysfunction in Young Men Living With HIV

Andrology, EarlyView.
ABSTRACT Background Erectile dysfunction (ED) is a multidimensional condition commonly affecting men living with HIV. The structured interview of erectile dysfunction (SIEDY) is the only validated tool assessing organic, relational, and psychological factors contributing to ED, while dynamic penile color Doppler ultrasound (dPCDU) is a reliable method ...
Giorgio Tiecco, Federico Cesanelli, Cosimo Colangelo, Marco Di Gregorio, Andrea Delbarba, Paolo Facondo, Matteo Riva, Carlo Cappelli, Emanuele Focà, Francesco Castelli, Eugenia Quiros‐Roldan   +10 more
wiley   +1 more source

RNF213 isoform 2 restricts Zika virus through antiviral signaling and viral protein degradation. [PDF]

iScience
Yang X, Chen T, Ren B, Liu J, Xu Z, Wang J, Shi Y, Liu L, Li L, Cheng G, Zhou D, Chen Q, Zu S.   +12 more
europepmc   +1 more source

Micro‐Nanoplastics Significantly Increase Adverse Events and Economic Burden Associated With Carotid Endarterectomy: A Health Economic Modelling Evaluation

ANZ Journal of Surgery, EarlyView.
Current research reports that micro‐nanoplastics may increase the burden of cardiovascular disease with significant human and economic consequences. The detection of plastic particles in biological matrices is challenging and rigorous research is required to investigate the clinical and broader public health implications of microplastics.
Adrian Goldsworthy, Marcus Randall, Oystein Tronstad, Jacky Suen, John F. Fraser   +4 more
wiley   +1 more source

Stability of the two enveloped viruses NDV LaSota and YF-ZIKprM/E to support process development. [PDF]

PLoS One
Göbel S, Jacobtorweihe L, Rössig ML, Braatz F, Perugi F, Genzel Y, Reichl U.   +6 more
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

A rapid yeast-based reverse genetics system reveals SARS-CoV-2 Omicron BA.2.86 variant spreads faster than Omicron JN.1 variant in primary human nasal and bronchial epithelial airway cultures. [PDF]

mBio
Xu J, Chamblee M, Hsu CC, Jiang F, Chen P, Zhang Y, Liang X, Amer AO, Boyaka PN, Cormet-Boyaka E, Peeples ME, Li J.   +11 more
europepmc   +1 more source