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Exploiting Connections for Viral Replication [PDF]
Frontiers in Cell and Developmental Biology, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 (coronavirus disease 2019) pandemic, is a positive strand RNA (+RNA) virus.
L. H. Wong +4 more
semanticscholar +7 more sources
Cooperative nature of viral replication [PDF]
Science Advances, 2020 Group transmission of viruses accelerates early replication and increases short-term viral fitness. The ability of viruses to infect their hosts depends on rapid dissemination following transmission.
Iván Andreu-Moreno +2 more
semanticscholar +5 more sources
The Role of APOBECs in Viral Replication [PDF]
Microorganisms, 2020 Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) proteins are a diverse and evolutionarily conserved family of cytidine deaminases that provide a variety of functions from tissue-specific gene expression and immunoglobulin ...
Wendy Kaichun Xu, H. Byun, J. Dudley
semanticscholar +6 more sources
SUMOylation in Viral Replication and Antiviral Defense [PDF]
Advanced Science, 2022 SUMOylation is a ubiquitination‐like post‐translational modification that plays an essential role in the regulation of protein function. Recent studies have shown that proteins from both RNA and DNA virus families can be modified by SUMO conjugation ...
Yao-min Fan +10 more
semanticscholar +4 more sources
Enrichment of Phosphatidylethanolamine in Viral Replication Compartments via Co-opting the Endosomal Rab5 Small GTPase by a Positive-Strand RNA Virus. [PDF]
PLoS Biology, 2016 Positive-strand RNA viruses build extensive membranous replication compartments to support replication and protect the virus from antiviral responses by the host.
Kai Xu, Peter D Nagy
doaj +2 more sources
Hepatitis C Viral Replication Complex [PDF]
Viruses, 2021 The life cycle of the hepatitis C virus (HCV) can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release.
Hui-Chun Li, Chee-Hing Yang, Shih-Yen Lo
doaj +4 more sources
Epigenetic and epitranscriptomic regulation of viral replication [PDF]
Nature Reviews Microbiology, 2020 Eukaryotic gene expression is regulated not only by genomic enhancers and promoters, but also by covalent modifications added to both chromatin and RNAs.
K. Tsai, B. Cullen
semanticscholar +3 more sources
Enhanced Viral Replication by Cellular Replicative Senescence [PDF]
Immune Network, 2016 Cellular replicative senescence is a major contributing factor to aging and to the development and progression of aging-associated diseases. In this study, we sought to determine viral replication efficiency of influenza virus (IFV) and Varicella Zoster ...
Ji-Ae Kim, Rak-Kyun Seong, O. S. Shin
semanticscholar +4 more sources
Viruses, 2021 The 3C-like protease (3CLpro) of SARS-CoV-2 is considered an excellent target for COVID-19 antiviral drug development because it is essential for viral replication and has a cleavage specificity distinct from human proteases.
Jonathan M. O. Rawson +4 more
doaj +1 more source
mBio, 2022 We provide the first evidence for the role of ACSL4 in enterovirus replication organelle formation. Moreover, both enteroviruses and coronaviruses induce ferroptosis via ACSL4.
Yu-An Kung +11 more
semanticscholar +1 more source