Results 1 to 10 of about 438,262 (317)

Hepatitis C Viral Replication Complex [PDF]

Viruses, 2021
The life cycle of the hepatitis C virus (HCV) can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release.
Hui-Chun Li, Chee-Hing Yang, Shih-Yen Lo
doaj   +3 more sources

Iron limitation differentially affects viral replication in key marine microbes. [PDF]

Proc Natl Acad Sci U S A
Yung CCM, Kelly RL, Kauffman KM, Cunningham BR, Zimmerman AE, Worden AZ, John SG.   +6 more
europepmc   +2 more sources

Development of a Cell-Based Luciferase Complementation Assay for Identification of SARS-CoV-2 3CL^pro Inhibitors

Viruses, 2021
The 3C-like protease (3CLpro) of SARS-CoV-2 is considered an excellent target for COVID-19 antiviral drug development because it is essential for viral replication and has a cleavage specificity distinct from human proteases.
Jonathan M. O. Rawson, Alice Duchon, Olga A. Nikolaitchik, Vinay K. Pathak, Wei-Shau Hu   +4 more
doaj   +1 more source

Plasma Membrane Anchoring and Gag:Gag Multimerization on Viral RNA Are Critical Properties of HIV-1 Gag Required To Mediate Efficient Genome Packaging

mBio, 2021
Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA.
Alice Duchon, Steven Santos, Jianbo Chen, Matthew Brown, Olga A. Nikolaitchik, Sheldon Tai, Jeffrey A. Chao, Eric O. Freed, Vinay K. Pathak, Wei-Shau Hu   +9 more
doaj   +1 more source

Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication

mBio, 2022
Frequent recombination is a hallmark of retrovirus replication. In rare cases, recombination occurs between distantly related retroviruses, generating novel viruses that may significantly impact viral evolution and public health.
Jonathan M. O. Rawson, Olga A. Nikolaitchik, Jennifer A. Yoo, Xayathed Somoulay, Matthew A. Brown, Franck S. Mbuntcha Bogni, Vinay K. Pathak, Ferri Soheilian, Ryan L. Slack, Stefan G. Sarafianos, Wei-Shau Hu   +10 more
doaj   +1 more source

Exploiting Connections for Viral Replication [PDF]

Frontiers in Cell and Developmental Biology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 (coronavirus disease 2019) pandemic, is a positive strand RNA (+RNA) virus. Like other +RNA viruses, SARS-CoV-2 is dependent on host cell metabolic machinery to survive and replicate, remodeling cellular membranes to generate sites of viral replication.
Wong, LH, Edgar, JR, Martello, A, Ferguson, BJ, Eden, ER   +4 more
openaire   +5 more sources

Transcription Start Site Heterogeneity and Preferential Packaging of Specific Full-Length RNA Species Are Conserved Features of Primate Lentiviruses

Microbiology Spectrum, 2022
HIV-1 must package its RNA genome to generate infectious viruses. Recent studies have revealed that during genome packaging, HIV-1 not only excludes cellular mRNAs, but also distinguishes among full-length viral RNAs. Using NL4-3 and MAL molecular clones,
Jonathan M. O. Rawson, Olga A. Nikolaitchik, Saurabh Shakya, Brandon F. Keele, Vinay K. Pathak, Wei-Shau Hu   +5 more
doaj   +1 more source

Special Issue: “Viral Replication Complexes” [PDF]

Viruses, 2021
Viruses are extraordinary biological entities that can only thrive as obligate intracellular parasites, exploiting other living cellular components in order to reproduce [...]
Núria Verdaguer, Diego S. Ferrero
openaire   +4 more sources

Cooperative nature of viral replication [PDF]

Science Advances, 2020
Group transmission of viruses accelerates early replication and increases short-term viral fitness.
Iván Andreu-Moreno, Juan-Vicente Bou, Rafael Sanjuán   +2 more
openaire   +3 more sources

Cytoplasmic Viral Replication Complexes [PDF]

Cell Host & Microbe, 2010
Many viruses that replicate in the cytoplasm compartmentalize their genome replication and transcription in organelle-like structures that enhance replication efficiency and protection from host defenses. In particular, recent studies with diverse positive-strand RNA viruses have further elucidated the ultrastructure of membrane-bound RNA replication ...
den Boon, Johan A., Diaz, Arturo, Ahlquist, Paul   +2 more
openaire   +2 more sources