Results 11 to 20 of about 366,840 (272)
Microbiology Spectrum, 2021 Picornaviruses are a diverse and major cause of human disease, and their genomes replicate with intracellular membranes. The functionality of these replication organelles depends on the activities of both viral nonstructural proteins and co-opted host ...
Jia-Ying Lu +6 more
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Analysis of the Replication Mechanisms of the Human Papillomavirus Genomes
Frontiers in Microbiology, 2021 The life-cycle of human papillomaviruses (HPVs) includes three distinct phases of the viral genome replication. First, the viral genome is amplified in the infected cells, and this amplification is often accompanied by the oligomerization of the viral ...
Lisett Liblekas +7 more
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Phenotypic continuum of NFU1‐related disorders
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022 Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov +45 more
wiley +1 more source
mBio, 2022 The relationship between spatiotemporal distribution of HIV-1 proviruses and their transcriptional activity is not well understood. To elucidate the intranuclear positions of transcriptionally active HIV-1 proviruses, we utilized an RNA fluorescence in ...
Ryan C. Burdick +5 more
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Depletion of cellular pre-replication complex factors results in increased human cytomegalovirus DNA replication. [PDF]
PLoS ONE, 2012 Although HCMV encodes many genes required for the replication of its DNA genome, no HCMV-encoded orthologue of the origin binding protein, which has been identified in other herpesviruses, has been identified.
Tamara Evans Braun +2 more
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Microbiology Spectrum, 2021 Upon Kaposi’s Sarcoma-associated herpesvirus (KSHV) lytic reactivation, rapid and widespread amplification of viral DNA (vDNA) triggers significant nuclear reorganization.
D. Hoffman +4 more
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Enrichment of Phosphatidylethanolamine in Viral Replication Compartments via Co-opting the Endosomal Rab5 Small GTPase by a Positive-Strand RNA Virus. [PDF]
PLoS Biology, 2016 Positive-strand RNA viruses build extensive membranous replication compartments to support replication and protect the virus from antiviral responses by the host.
Kai Xu, Peter D Nagy
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PLoS Pathogens, 2022 As ultimate parasites, viruses depend on host factors for every step of their life cycle. On the other hand, cells evolved multiple mechanisms of detecting and interfering with viral replication.
Seyedehmahsa Moghimi +7 more
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Slowly replicating lytic viruses: pseudolysogenic persistence and within-host competition [PDF]
Phys. Rev. Lett. 102, 178103 (2009), 2008 We study the population dynamics of lytic viruses which replicate slowly in dividing host cells within an organism or cell culture, and find a range of viral replication rates that allows viruses to persist, avoiding extinction of host cells or dilution of viruses at too rapid or too slow viral replication.
arxiv +1 more source
Classification of capped tubular viral particles in the family of Papovaviridae [PDF]
J.Phys.:Condens.Matter 18 (2006) S375-S387, 2005 A vital constituent of a virus is its protein shell, called the viral capsid, that encapsulates and hence provides protection for the viral genome. Viral capsids are usually spherical, and for a significant number of viruses exhibit overall icosahedral symmetry.
arxiv +1 more source