Results 11 to 20 of about 2,128,088 (408)

Development of a Cell-Based Luciferase Complementation Assay for Identification of SARS-CoV-2 3CL^pro Inhibitors

Viruses, 2021
The 3C-like protease (3CLpro) of SARS-CoV-2 is considered an excellent target for COVID-19 antiviral drug development because it is essential for viral replication and has a cleavage specificity distinct from human proteases.
Jonathan M. O. Rawson, Alice Duchon, Olga A. Nikolaitchik, Vinay K. Pathak, Wei-Shau Hu   +4 more
doaj   +1 more source

Acyl-Coenzyme A Synthetase Long-Chain Family Member 4 Is Involved in Viral Replication Organelle Formation and Facilitates Virus Replication via Ferroptosis

mBio, 2022
We provide the first evidence for the role of ACSL4 in enterovirus replication organelle formation. Moreover, both enteroviruses and coronaviruses induce ferroptosis via ACSL4.
Yu-An Kung, Huan-Jung Chiang, Mei-Ling Li, Yu-Nong Gong, Hsin-Ping Chiu, Chuan-tien Hung, Peng-Nien Huang, Sheng-Yu Huang, Pei-Yu Wang, T. Hsu, G. Brewer, S. Shih   +11 more
semanticscholar   +1 more source

Plasma Membrane Anchoring and Gag:Gag Multimerization on Viral RNA Are Critical Properties of HIV-1 Gag Required To Mediate Efficient Genome Packaging

mBio, 2021
Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA.
Alice Duchon, Steven Santos, Jianbo Chen, Matthew Brown, Olga A. Nikolaitchik, Sheldon Tai, Jeffrey A. Chao, Eric O. Freed, Vinay K. Pathak, Wei-Shau Hu   +9 more
doaj   +1 more source

Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication

Science Signaling, 2022
Multiple coronaviruses have emerged independently in the past 20 years that cause lethal human diseases. Although vaccine development targeting these viruses has been accelerated substantially, there remain patients requiring treatment who cannot be ...
Tomer M. Yaron, B. Heaton, T. Levy, Jared L. Johnson, Tristan X. Jordan, Benjamin M. Cohen, A. Kerelsky, Ting-Yu Lin, Katarina M Liberatore, Danielle K Bulaon, Samantha J. Van Nest, Nikos Koundouros, Edward R. Kastenhuber, Marisa Mercadante, Kripa Shobana-Ganesh, Long He, R. Schwartz, Shuibing Chen, H. Weinstein, O. Elemento, E. Piskounova, Benjamin E. Nilsson-Payant, Gina Lee, Joseph D. Trimarco, Kaitlyn N. Burke, C. Hamele, Ryan R. Chaparian, Alfred T. Harding, A. Tata, Xinyu Zhu, P. R. Tata, Clare M. Smith, A. Possemato, Sasha L. Tkachev, P. Hornbeck, S. Beausoleil, Shankara K. Anand, F. Aguet, G. Getz, A. Davidson, K. Heesom, M. Kavanagh-Williamson, D. Matthews, B. tenOever, L. Cantley, J. Blenis, Nicholas S. Heaton   +46 more
semanticscholar   +1 more source

Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication

mBio, 2022
Frequent recombination is a hallmark of retrovirus replication. In rare cases, recombination occurs between distantly related retroviruses, generating novel viruses that may significantly impact viral evolution and public health.
Jonathan M. O. Rawson, Olga A. Nikolaitchik, Jennifer A. Yoo, Xayathed Somoulay, Matthew A. Brown, Franck S. Mbuntcha Bogni, Vinay K. Pathak, Ferri Soheilian, Ryan L. Slack, Stefan G. Sarafianos, Wei-Shau Hu   +10 more
doaj   +1 more source

Transcription Start Site Heterogeneity and Preferential Packaging of Specific Full-Length RNA Species Are Conserved Features of Primate Lentiviruses

Microbiology Spectrum, 2022
HIV-1 must package its RNA genome to generate infectious viruses. Recent studies have revealed that during genome packaging, HIV-1 not only excludes cellular mRNAs, but also distinguishes among full-length viral RNAs. Using NL4-3 and MAL molecular clones,
Jonathan M. O. Rawson, Olga A. Nikolaitchik, Saurabh Shakya, Brandon F. Keele, Vinay K. Pathak, Wei-Shau Hu   +5 more
doaj   +1 more source

SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

Nature Communications, 2021
The recently identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. How this novel beta-coronavirus virus, and coronaviruses more generally, alter cellular metabolism to support massive production ...
Yuchen Zhang, Rui Guo, S. H. Kim, Hardik Shah, Shuting Zhang, Jin-Hua Liang, Ying Fang, M. Gentili, Colin N O' Leary, S. Elledge, D. Hung, V. Mootha, B. Gewurz   +12 more
semanticscholar   +1 more source

SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication

Cell Discovery, 2021
The newly emerging coronavirus SARS-CoV-2 causes severe lung disease and substantial mortality. How the virus evades host defense for efficient replication is not fully understood.
Zhou-Qin Zheng, Su-yun Wang, Zhi-Sheng Xu, Yu-Zhi Fu, Yan-Yi Wang   +4 more
semanticscholar   +1 more source

Therapeutic Interfering Particles Exploiting Viral Replication and Assembly Mechanisms Show Promising Performance: A Modelling Study [PDF]

Scientific Reports, 11, 23847 (2021), 2021
Defective interfering particles arise spontaneously during a viral infection as mutants lacking essential parts of the viral genome. Their ability to replicate in the presence of the wild-type (WT) virus (at the expense of viable viral particles) is mimicked and exploited by therapeutic interfering particles.
arxiv   +1 more source

Endocytosis in Viral Replication [PDF]

Traffic, 2000
Although initially recognised as essential for the entry of certain viruses, endocytosis is now known to also play important roles in the replication of, and adaptation to, the host cell of a number of viruses. Here we consider several aspects of this association and recent results that have emerged to support this view.
Annegret Pelchen-Matthews, Mark Marsh
openaire   +3 more sources