Results 81 to 90 of about 2,128,088 (408)
Emerging coronaviruses: Genome structure, replication, and pathogenesis
Journal of Medical Virology, 2020 The recent emergence of a novel coronavirus (2019‐nCoV), which is causing an outbreak of unusual viral pneumonia in patients in Wuhan, a central city in China, is another warning of the risk of CoVs posed to public health.
Yu Chen, Qianyun Liu, D. Guo
semanticscholar +1 more source
RNase P Ribozymes Inhibit the Replication of Human Cytomegalovirus by Targeting Essential Viral Capsid Proteins. [PDF]
, 2015 An engineered RNase P-based ribozyme variant, which was generated using the in vitro selection procedure, was used to target the overlapping mRNA region of two proteins essential for human cytomegalovirus (HCMV) replication: capsid assembly protein (AP ...
LIU, Fenyong +9 more
core +3 more sources
Replication of Epstein-Barr Viral DNA [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Epstein-Barr virus (EBV) is a paradigm for human tumor viruses: it is the first virus recognized to cause cancer in people; it causes both lymphomas and carcinomas; yet these tumors arise infrequently given that most people in the world are infected with the virus. EBV is maintained extrachromosomally in infected normal and tumor cells.
Hammerschmidt, W., Sugden, B.
openaire +4 more sources
Viral quasispecies profiles as the result of the interplay of competition and cooperation [PDF]
BMC Evolutionary Biology 2010 10:137, 2010 Viral quasispecies can be regarded as a swarm of genetically related mutants or a quasispecies (QS). A common formalism to approach QS is the replicator-mutator equation (RME). However, a problem with the RME is how to quantify the interaction coefficients between viral variants.
arxiv +1 more source
FUSE binding protein FUBP3 is a potent regulator in Japanese encephalitis virus infection
Virology Journal, 2021 Background The JEV genome is a positive-sense RNA with a highly structured capped 5′UTR, 3′UTR and a large open reading frame. 3′UTR is the untranslated region of flavivirus and has various important functions during viral replication, such as ...
Peng Xu, Wei Tong, Young-Mao Chen
doaj +1 more source
Rhinovirus induces an anabolic reprogramming in host cell metabolism essential for viral replication
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Rhinovirus (RV) is the causative agent of the common cold and other respiratory tract infections. Despite the vast prevalence, effective treatment or prevention strategies are lacking.
Guido A. Gualdoni +11 more
semanticscholar +1 more source
Coronavirus biology and replication: implications for SARS-CoV-2
Nature Reviews Microbiology, 2020 The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the human population.
P. V’kovski +4 more
semanticscholar +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Selection strategies for randomly partitioned genetic replicators [PDF]
Phys. Rev. E 99, 062416 (2019), 2017 The amplification cycle of many replicators (natural or artificial) involves the usage of a host compartment, inside of which the replicator express phenotypic compounds necessary to carry out its genetic replication. For example, viruses infect cells, where they express their own proteins and replicate.
arxiv +1 more source
IFITM proteins inhibit the late step of feline foamy virus replication
Animal Cells and Systems, 2020 Interferon-induced transmembrane (IFITM) proteins as host restriction factors are known to inhibit the replication of several viruses. In this study, transient IFITM expression vectors were used to investigate whether IFITMs inhibit feline foamy viral ...
Jinsun Kim, Cha-Gyun Shin
doaj +1 more source