Results 1 to 10 of about 145,832 (187)
Predicting Post-treatment HIV Remission: Does Size of the Viral Reservoir Matter? [PDF]
Frontiers in Microbiology, 2021 Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) replication and improves immune function. However, due to the persistence of long-lived HIV reservoirs, therapy interruption almost inevitably leads to a fast viral ...
Alexander O. Pasternak +2 more
doaj +2 more sources
Neuroinvasion and Viral Reservoir in COVID-19. [PDF]
Cureus, 2020 The new coronavirus disease 2019 (COVID-19) has a remarkably high transmissibility potential and sometimes invades the central nervous system (CNS). The study of the involvement of the nervous system in the pathogenesis of the disease is especially interesting.
Altable Pérez M, De la Serna JM.
europepmc +4 more sources
Early and Highly Suppressive Antiretroviral Therapy Are Main Factors Associated With Low Viral Reservoir in European Perinatally HIV-Infected Children. [PDF]
J Acquir Immune Defic Syndr, 2018 BACKGROUND: Future strategies aiming to achieve HIV-1 remission are likely to target individuals with small reservoir size. SETTING: We retrospectively investigated factors associated with HIV-1 DNA levels in European, perinatally HIV-infected ...
Tagarro A +21 more
europepmc +4 more sources
Contextualizing bats as viral reservoirs [PDF]
Science, 2020 Preventing zoonotic emergence from bats requires integrative ...
Streicker, Daniel G., Gilbert, Amy T.
openaire +2 more sources
mBio, 2022 Combined Antiretroviral therapy (cART) suppresses HIV replication but fails to eradicate the virus, which persists in a small pool of long-lived latently infected cells. Immune activation and residual inflammation during cART are considered to contribute
Julia Rubione +20 more
doaj +1 more source
Glycoengineering of AAV-delivered monoclonal antibodies yields increased ADCC activity
Molecular Therapy: Methods & Clinical Development, 2021 The absence of fucose on asparagine-297 of the human immunoglobulin G (IgG) heavy chain has been shown to enhance antibody-dependent cellular cytotoxicity (ADCC) activity by 10- to 100-fold compared to fucosylated antibody. Our lab is studying the use of
James M. Termini +4 more
doaj +1 more source
HIV-1 Infection of Long-Lived Hematopoietic Precursors In Vitro and In Vivo
Cells, 2022 Latent reservoirs in human-immunodeficiency-virus-1 (HIV-1)-infected individuals represent a major obstacle in finding a cure for HIV-1. Hematopoietic stem and progenitor cells (HSPCs) have been described as potential HIV-1 targets, but their roles as ...
Sebastian Renelt +11 more
doaj +1 more source
Microglial HIV-1 Expression: Role in HIV-1 Associated Neurocognitive Disorders
Viruses, 2021 The persistence of HIV-1 viral reservoirs in the brain, despite treatment with combination antiretroviral therapy (cART), remains a critical roadblock for the development of a novel cure strategy for HIV-1.
Hailong Li +4 more
doaj +1 more source
Confined aquifers as viral reservoirs [PDF]
Environmental Microbiology Reports, 2013 Summary Knowledge about viral diversity and abundance in deep groundwater reserves is limited. We found that the viral community inhabiting a deep confined aquifer in S outh A ustralia was more similar to reclaimed water communities ...
Smith, Renee J +9 more
openaire +3 more sources
Impact of monotherapy on HIV-1 reservoir, immune activation, and co-infection with Epstein-Barr virus [PDF]
, 2017 Objectives Although monotherapy (mART) effectiveness in maintaining viral suppression and CD4 cell count has been extensively examined in HIV-1-infected patients, its impact on HIV-1 reservoir, immune activation, microbial translocation and co-infection
Carmona, Francesco +8 more
core +13 more sources