Results 101 to 110 of about 145,951 (305)

A Proof‐of‐Concept Assessment of a Novel Wearable Eyelid Muscle Device: A Pre‐Clinical Animal Cadaver Study for Eyelid Closure Restoration

Advanced Robotics Research, EarlyView.
This article introduces a soft wearable eyelid sling device incorporating a hydraulic soft artificial muscle (SAM) for achieving complete closure of an eyelid. The SAM is driven by a cam mechanism that provides a displacement profile closely matched with those of a healthy eyelid.
Patrick Pruscino, Phuoc Thien Phan, James Davies, Bibhu Sharma, Tianruo Guo, Chi Cong Nguyen, Nigel H. Lovell, Thanh Nho Do   +7 more
wiley   +1 more source

Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques

mBio, 2019
Human immunodeficiency virus (HIV) eradication or long-term suppression in the absence of antiretroviral therapy (ART) requires an understanding of all viral reservoirs that could contribute to viral rebound after ART interruption. CD4 T cells (CD4s) are
Celina M. Abreu, Rebecca T. Veenhuis, Claudia R. Avalos, Shelby Graham, Daymond R. Parrilla, Edna A. Ferreira, Suzanne E. Queen, Erin N. Shirk, Brandon T. Bullock, Ming Li, Kelly A. Metcalf Pate, Sarah E. Beck, Lisa M. Mangus, Joseph L. Mankowski, Feilim Mac Gabhann, Shelby L. O’Connor, Lucio Gama, Janice E. Clements   +17 more
doaj   +1 more source

Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus [PDF]

, 2014
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first documented in the Kingdom of Saudi Arabia (KSA) in 2012 and, to date, has been identified in 180 cases with 43% mortality.
Al Rabeeah, Abdullah A., Al-Tawfiq, Jaffar A., Albarrak, Ali, Alhakeem, Rafat F., Alrabiah, Fahad A., Assiri, Abdullah, Balkhy, Hanan H., Barry, Mazin, Cotten, Matthew, Flemban, Hesham, Hajjar, Sami, Katze, Michael G., Kellam, Paul, Makhdoom, Hatem Q., Memish, Ziad A., Ong, Swee Hoe, Palser, Anne L., Rambaut, Andrew, Shibl, Atef, Watson, Simon J., Zumla, Alimuddin I.   +20 more
core   +3 more sources

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women

Journal of Virology
HIV-1 Nef mediates immune evasion and viral pathogenesis in part through the downregulation of cell surface cluster of differentiation 4 (CD4) and major histocompatibility complex class I (MHC-I) on infected cells.
Sherazaan D. Ismail, Shorok Sebaa, Bianca Abrahams, Martha C. Nason, Mitchell J. Mumby, Jimmy D. Dikeakos, Sarah B. Joseph, Matthew Moeser, Ronald Swanstrom, Nigel Garrett, Carolyn Williamson, Thomas C. Quinn, Melissa-Rose Abrahams, Andrew D. Redd   +13 more
doaj   +1 more source

The Stochastic Dance of Early HIV Infection [PDF]

, 2005
The stochastic nature of early HIV infection is described in a series of models, each of which captures aspects of the dance of HIV during the early stages of infection. It is to this highly variable target that the immune response must respond.
Merrill, Stephen J.
core   +1 more source

Longitudinal sequencing of HIV-1 infected patients with low-level viremia for years while on ART shows no indications for genetic evolution of the virus [PDF]

, 2017
HIV-infected patients on antiretroviral therapy (ART) may present low-level viremia (LLV) above the detection level of current viral load assays.
Dauwe, Kenny, Demecheleer, Els, Dinakis, Sylvie, Hebberecht, Laura, Mortier, Virginie, Vancoillie, Leen, Vaneechoutte, Dries, Verhofstede, Chris   +7 more
core   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

TZA, a Sensitive Reporter Cell-based Assay to Accurately and Rapidly Quantify Inducible, Replication-competent Latent HIV-1 from Resting CD4+ T Cells

Bio-Protocol, 2019
The latent HIV-1 viral reservoir in resting CD4+ (rCD4+) T cells represents a major barrier to an HIV-1 cure. There is an ongoing effort to identify therapeutic approaches that will eliminate or reduce the size of this reservoir.
Anwesha Sanyal, Vatsala Rangachar, Phalguni Gupta   +2 more
doaj   +1 more source

Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection [PDF]

, 2015
HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts.
Borrow, Persephone, Chain, Benjamin M., Groppelli, Elisabetta, Jolly, Clare, Pellegrino, Pierre, Williams, Ian, Zhang, Changwang, Zhou, Shi   +7 more
core   +4 more sources