Switching from a protease inhibitor-based regimen to a dolutegravir-based regimen : a randomized clinical trial to determine the effect on peripheral blood and ileum biopsies from antiretroviral therapy-suppressed human immunodeficiency virus-infected individuals [PDF]
, 2018 Background: Optimization of combination antiretroviral therapy (cART) can impact the human immunodeficiency virus (HIV) reservoir. We evaluated the effect on the HIV reservoir in peripheral blood and ileum biopsies in patients switching from boosted ...
Blanco, Julià +15 more
core +3 more sources
Monocytes and Macrophages as Viral Targets and Reservoirs [PDF]
International Journal of Molecular Sciences, 2018 Viruses manipulate cell biology to utilize monocytes/macrophages as vessels for dissemination, long-term persistence within tissues and virus replication. Viruses enter cells through endocytosis, phagocytosis, macropinocytosis or membrane fusion. These processes play important roles in the mechanisms contributing to the pathogenesis of these agents and
Nikitina, Ekaterina +3 more
openaire +2 more sources
Spatial expansions and travelling waves of rabies in vampire bats [PDF]
, 2016 A major obstacle to anticipating the cross-species transmission of zoonotic diseases and developing novel strategies for their control is the scarcity of data informing how these pathogens circulate within natural reservoir populations.
Benavides, Julio A. +2 more
core +1 more source
Journal of Virus Eradication, 2021 HIV-1 is able to persist in the face of potent antiretroviral therapy (ART). A number of strategies are being explored to allow ART-free viral remission or viral eradication.
M. Vignoles +8 more
doaj +1 more source
Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals. [PDF]
, 2019 Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Bale, Michael J +13 more
core +1 more source
Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy. [PDF]
PLoS Computational Biology, 2009 Although potent combination therapy is usually able to suppress plasma viral loads in HIV-1 patients to below the detection limit of conventional clinical assays, a low level of viremia frequently can be detected in plasma by more sensitive assays ...
Libin Rong, Alan S Perelson
doaj +1 more source
Extracellular Vesicles as a New Promising Therapy in HIV Infection
Frontiers in Immunology, 2022 Combination antiretroviral therapy (cART) effectively blocks HIV replication but cannot completely eliminate HIV from the body mainly due to establishment of a viral reservoir.
Maria A. Navarrete-Muñoz +7 more
doaj +1 more source
HTLV-1 as a Model for Virus and Host Coordinated Immunoediting
Frontiers in Immunology, 2019 Immunoediting is a process that occurs in cancer, whereby the immune system acts to initially repress, and subsequently promote the outgrowth of tumor cells through the stages of elimination, equilibrium, and escape.
Talia M. Mota +2 more
doaj +1 more source
Interventions for neurocognitive dysfunction [PDF]
, 2017 Purpose of review: To evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last three years. Recent findings: Optimal anti-retroviral therapy (ART) poses
Brew, B, Ellero, J, Lubomski, M
core +2 more sources
Domestic Animals as Potential Reservoirs of Zoonotic Viral Diseases
Annual Review of Animal Biosciences, 2023 Zoonoses are diseases and infections naturally transmitted between humans and vertebrate animals. Over the years, zoonoses have become increasingly significant threats to global health. They form the dominant group of diseases among the emerging infectious diseases (EID) and currently account for 73% of EID.
Oyewale, Tomori, Daniel O, Oluwayelu
openaire +2 more sources