Optimising predictive models to prioritise viral discovery in zoonotic reservoirs [PDF]
The Lancet Microbe, 2022 (Uploaded by Plazi for the Bat Literature Project) No abstract provided.
Becker, Daniel J. +16 more
openaire +5 more sources
Viral and latent reservoir persistence in HIV-1-infected patients on therapy. [PDF]
PLoS Computational Biology, 2006 Despite many years of potent antiretroviral therapy, latently infected cells and low levels of plasma virus have been found to persist in HIV-infected patients. The factors influencing this persistence and their relative contributions have not been fully
Hwijin Kim, Alan S Perelson
doaj +1 more source
Genetic diversity in the env V1-V2 region of proviral quasispecies from long-term controller MHC-typed cynomolgus macaques infected with SHIVSF162P4cy [PDF]
, 2018 Intra-host evolution of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) has been shown by viral RNA analysis in subjects who naturally suppress plasma viremia to low levels, known as controllers.
Borsetti, Alessandra +11 more
core +1 more source
Emerging PCR-based techniques to study HIV-1 reservoir persistence [PDF]
, 2020 While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Cole, Basiel +4 more
core +2 more sources
Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir
eLife, 2018 Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts.
Alex C Stabell +7 more
doaj +1 more source
Relationship between intact HIV-1 proviruses in circulating CD4+ T cells and rebound viruses emerging during treatment interruption. [PDF]
, 2018 Combination antiretroviral therapy controls but does not cure HIV-1 infection because a small fraction of cells harbor latent viruses that can produce rebound viremia when therapy is interrupted. The circulating latent virus reservoir has been documented
Barton, John +13 more
core +1 more source
Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. [PDF]
, 2016 Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Abdel-Mohsen, Mohamed +17 more
core +7 more sources
Targeting viral reservoirs: ability of antiretroviral therapy to stop viral replication [PDF]
Current Opinion in HIV and AIDS, 2011 HIV infection is controlled but not cured by combination antiretroviral therapy. HIV may persist for a number of reasons, including ongoing cycles of HIV infection or viral persistence as latent, or HIV replication in long-lived cells containing HIV proviruses. Therapeutic consequences of these alternative mechanisms are significant and distinct.
openaire +2 more sources
Forging a Functional Cure for HIV: Transcription Regulators and Inhibitors
Viruses, 2022 Current antiretroviral therapy (ART) increases the survival of HIV-infected individuals, yet it is not curative. The major barrier to finding a definitive cure for HIV is our inability to identify and eliminate long-lived cells containing the dormant ...
Sonia Mediouni +3 more
doaj +1 more source
, 2020 Although HIV-1 has evolved from a deadly to a chronic disease over the past 20 years, an HIV-1 cure is still lacking due to the presence of persisting cellular viral reservoirs which are spread throughout the body in different anatomical compartments ...
De Scheerder, Marie-Angélique +3 more
core +1 more source