Results 41 to 50 of about 145,951 (305)
Digital PCR as a tool to measure HIV persistence [PDF]
, 2018 Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped.
Bosman, Kobus +4 more
core +1 more source
Modeling HIV persistence, the latent reservoir, and viral blips [PDF]
Journal of Theoretical Biology, 2009 HIV-1 eradication from infected individuals has not been achieved with the prolonged use of highly active antiretroviral therapy (HAART). The cellular reservoir for HIV-1 in resting memory CD4(+) T cells remains a major obstacle to viral elimination. The reservoir does not decay significantly over long periods of time but is able to release replication-
Rong, Libin, Perelson, Alan S.
openaire +2 more sources
Highlights from the 24th conference on retroviruses and opportunistic infections, 13-16 February 2017, Seattle, Washington, USA [PDF]
, 2017 From the 13th to 16th February 2017, researchers from around the world convened for the 24th annual Conference on Retroviruses and Opportunistic Infections (CROI) at the Washington State Convention Center in Seattle, Washington.
Bhagani, Sanjay +12 more
core +5 more sources
Frontiers in PharmacologyHIV-1 infection cannot be cured due to long-lived viral reservoirs formed by latently infected CD4+ T cells. “Shock and Kill” strategy has been considered to eliminate the viral reservoir and achieve a functional cure but the stimulation of cytotoxic ...
Mario Manzanares +22 more
doaj +1 more source
The pathogenesis of zoonotic viral infections: Lessons learned by studying reservoir hosts
Frontiers in Microbiology, 2023 Zoonotic viral infections that cause severe disease or even death in some people may be asymptomatic or mild in reservoir hosts. Comparison of the pathogenesis of these two host categories may potentially explain the difference in disease.
Lineke Begeman +4 more
doaj +1 more source
Roadblocks to translational challenges on viral pathogenesis. [PDF]
, 2013 Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive ...
Deeks, Steven +4 more
core +1 more source
Detectable HIV-1 in semen in individuals with very low blood viral loads
Virology Journal, 2020 Background Several reports indicate that a portion (5–10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART).
Samuel Mundia Kariuki +6 more
doaj +1 more source
CCR5 gene editing and HIV immunotherapy: current understandings, challenges, and future directions
Frontiers in ImmunologyHuman immunodeficiency virus (HIV) infection remains a major global public health challenge. Although highly active antiretroviral therapy (HAART or ART) can effectively control viral replication, it fails to eradicate latent viral reservoirs and poses ...
Jia-Wen Wang, Jia-Hui Liu, Jian-Jun Xun
doaj +1 more source
Prediction and prevention of the next pandemic zoonosis. [PDF]
, 2012 Most pandemics--eg, HIV/AIDS, severe acute respiratory syndrome, pandemic influenza--originate in animals, are caused by viruses, and are driven to emerge by ecological, behavioural, or socioeconomic changes.
Carroll, Dennis +8 more
core +1 more source
Antigenic and genetic characterization of a divergent African virus, Ikoma lyssavirus [PDF]
, 2014 In 2009, a novel lyssavirus (subsequently named Ikoma lyssavirus, IKOV) was detected in the brain of an African civet (Civettictis civetta) with clinical rabies in the Serengeti National Park of Tanzania.
Alejandro Nunez +21 more
core +2 more sources