Results 81 to 90 of about 145,951 (305)

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

HBV cccDNA: The Molecular Reservoir of Hepatitis B Persistence and Challenges to Achieve Viral Eradication

Biomolecules
Hepatitis B virus (HBV) is a major global health issue, with an estimated 254 million people living with chronic HBV infection worldwide as of 2022. Chronic HBV infection is the leading cause of cirrhosis and liver cancer.
André Boonstra, Gulce Sari
doaj   +1 more source

Thermo‐Fluorescent Bactericidal Quantum Dots Based Smart Multifunctional Textiles via Molecular Surface Engineering and 3D‐Printed Interlocked Architectures

Advanced Healthcare Materials, EarlyView.
A versatile approach is presented for fabricating smart multifunctional textiles by integrating thermo‐fluorescent carbon dot/polymer nanocomposite coatings with 3D‐printed interlocked architectures. The fabrics exhibit temperature‐responsive fluorescence, durable hydrophobicity, strong antibacterial and antioxidant activity, and enhanced UV protection.
Poushali Das, Sayan Ganguly, Parham Khoshbakht Marvi, Misha Muthalali, Fatemeh Parniani, Shiza Hassan, Xiaowu (Shirley) Tang, Seshasai Srinivasan, Amin Reza Rajabzadeh   +8 more
wiley   +1 more source

Neutralizing the threat: harnessing broadly neutralizing antibodies against HIV-1 for treatment and prevention

Microbial Cell
Broadly neutralizing antibodies (bnAbs) targeting the human immunodeficiency virus-1 (HIV-1) have played a crucial role in elucidating and characterizing neutralization-sensitive sites on the HIV-1 envelope spike and in informing vaccine development ...
Juan C Becerra, Lauren Hitchcock, Khoa Vu, Johannes S Gach   +3 more
doaj   +1 more source

A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients.

PLoS Computational Biology, 2011
Motivated by viral persistence in HIV+ patients on long-term anti-retroviral treatment (ART), we present a stochastic model of HIV viral dynamics in the blood stream.
Jessica M Conway, Daniel Coombs
doaj   +1 more source

VP24-Karyopherin alpha binding affinities differ between Ebolavirus species, nfluencing interferon inhibition and VP24 stability [PDF]

, 2017
Zaire ebolavirus (EBOV), Bundibugyo ebolavirus (BDBV), and Reston ebolavirus (RESTV) belong to the same genus but exhibit different virulence properties.
Alinger, Joshua B, Amarasinghe, Gaya K, Basler, Christopher F, Diederichs, Audrey, Edwards, Megan R, Leung, Daisy W, Schwarz, Toni M   +6 more
core   +2 more sources

Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. [PDF]

, 2020
The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood.
Cavrois, Marielle, Deeks, Steven G, Frouard, Julie, Gramatica, Andrea, Greene, Warner C, Hoh, Rebecca, Hsiao, Feng, Jones, R Brad, Lee, Guinevere Q, Lee, Sulggi, Luo, Xiaoyu, Roan, Nadia R, Roychoudhury, Pavitra, Schwarzer, Roland, Telwatte, Sushama, Xie, Guorui, Yukl, Steven A   +16 more
core   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Effect of the Latent Reservoir on the Evolution of HIV at the Within- and Between-Host Levels.

PLoS Computational Biology, 2017
The existence of long-lived reservoirs of latently infected CD4+ T cells is the major barrier to curing HIV, and has been extensively studied in this light.
Hilje M Doekes, Christophe Fraser, Katrina A Lythgoe   +2 more
doaj   +1 more source

Molecular aspects of MERS-CoV [PDF]

, 2017
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Ahmed, Shamsah H., Al-Tawfiq, Jaffar A., Bazzi, Ali M., Rabaan, Ali A.   +3 more
core   +1 more source