Channel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites [PDF]
Scientific Reports, 2023 SARS-CoV-2 has been responsible for the major worldwide pandemic of COVID-19. Despite the enormous success of vaccination campaigns, virus infections are still prevalent and effective antiviral therapies are urgently needed.
Marina Sherif Fam +4 more
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Patch-clamp studies and cell viability assays suggest a distinct site for viroporin inhibitors on the E protein of SARS-CoV-2 [PDF]
Virology Journal, 2023 Background SARS-CoV-2 has caused a worldwide pandemic since December 2019 and the search for pharmaceutical targets against COVID-19 remains an important challenge. Here, we studied the envelope protein E of SARS-CoV and SARS-CoV-2, a highly conserved 75–
Ulrike Breitinger +3 more
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Poultry Science, 2021 : Duck hepatitis A virus 1 (DHAV-1) can cause high morbidity and fatal acute infectious hepatitis in ducklings, which seriously endangers animal husbandry. Viroporin is a small molecular weight hydrophobic transmembrane protein encoded by the virus, that
Zezheng Liu +13 more
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Does the Evidence Support the Existence of the Simian Polyomavirus SV40 Vp4 Viroporin? [PDF]
mSphere, 2020 The simian polyomavirus SV40 was reported to express Vp4, an N-terminally truncated form of the minor capsid proteins Vp2 and Vp3. Since a missense mutation of the putative Vp4 start codon (Vp2M228I) was found to give reduced progeny release and delayed ...
Stian Henriksen +1 more
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Vpu Protein: The Viroporin Encoded by HIV-1 [PDF]
Viruses, 2015 Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains.
María Eugenia González
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Viroporins: emerging viral infection mechanisms and therapeutic targets [PDF]
Journal of VirologyViroporins, virus-encoded small hydrophobic proteins, are involved in critical steps of viral infections by modulating ion homeostasis, disrupting host membrane integrity, and orchestrating key stages of the virus life cycle—from entry and replication to
Yuxin Qu +8 more
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Recovirus NS1-2 Has Viroporin Activity That Induces Aberrant Cellular Calcium Signaling To Facilitate Virus Replication [PDF]
mSphere, 2019 Enteric viruses in the Caliciviridae family cause acute gastroenteritis in humans and animals, but the cellular processes needed for virus replication and disease remain unknown.
Alicia C. Strtak +5 more
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The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism.
PLoS ONE, 2011 Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell restriction factor tetherin through its transmembrane domain.
Björn D Kuhl +6 more
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The 6-kilodalton peptide 1 of the family Potyviridae: small in size but powerful in function [PDF]
Frontiers in MicrobiologyThe Potyviridae family is one of the most economically significant groups of plant RNA viruses, causing severe yield losses in agriculturally important crops.
Liansheng Yu +7 more
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Frontiers in Microbiology, 2022 The exact function(s) of the lagovirus non-structural protein p23 is unknown as robust cell culture systems for the Rabbit haemorrhagic disease virus (RHDV) and other lagoviruses have not been established.
Elena Smertina +18 more
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