Results 91 to 100 of about 3,376 (179)

Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene‐Targeted Therapies

Reviews in Medical Virology, Volume 34, Issue 5, September 2024.
ABSTRACT Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer. The precise routes of transmission for MCPyV‐positive MCC remain unclear, but several factors may trigger its ...
Trairong Chokwassanasakulkit, Nigel A. J. McMillan   +1 more
wiley   +1 more source

Impact of histidine residues on the transmembrane helices of viroporins [PDF]

Molecular Membrane Biology, 2013
Abstract The role of histidine in channel-forming transmembrane (TM) helices was investigated by comparing the TM helices from Virus protein 'u' (Vpu) and the M2 proton channel. Both proteins are members of the viroporin family of small membrane proteins that exhibit ion channel activity, and have a single TM helix that is capable of forming oligomers.
Wang, Yan, Park, Sang Ho, Tian, Ye, Opella, Stanley J   +3 more
openaire   +4 more sources

Recent advances in hepatitis E virus research and the Japanese clinical practice guidelines for hepatitis E virus infection

Hepatology Research, Volume 54, Issue 8, Page 1-30, August 2024.
Abstract Acute hepatitis E was considered rare until reports emerged affirming the existence of hepatitis E virus (HEV) genotypes 3 and 4 infections in Japan in the early 2000s. Extensive studies by Japanese researchers have highlighted the pivotal role of pigs and wild animals, such as wild boars and deer, as reservoirs for HEV, linking them to ...
Tatsuo Kanda, Tian‐Cheng Li, Masaharu Takahashi, Shigeo Nagashima, Putu Prathiwi Primadharsini, Satoshi Kunita, Reina Sasaki‐Tanaka, Jun Inoue, Atsunori Tsuchiya, Shingo Nakamoto, Ryuzo Abe, Keiichi Fujiwara, Osamu Yokosuka, Ryosuke Suzuki, Koji Ishii, Hiroshi Yotsuyanagi, Hiroaki Okamoto, The AMED HAV and HEV Study Group, Mai Totsuka, Masayuki Honda, Shuhei Arima, Ryota Masuzaki, Naoki Matsumoto, Masahiro Ogawa, Hayato Abe, Masato Nakamura, Shuang Wu, Naoya Kato, Takeshi Yokoo, Kazunao Hayashi, Hiroteru Kamimura, Shuji Terai, Jong‐Hon Kang, Tominari Kobayashi, Norio Isoda, Shunji Watanabe, Hitoshi Mizuo, Junichi Koyama, Hitoshi Takagi, Yuichi Yamazaki, Yukihiro Sato, Hiroshi Okano, Tatsunori Nakano, Manri Kawakami, Akio Miyasaka, Tomohiko Koibuchi, Ryuichi Sugiyama, Mami Matsuda, Asuka Hirai‐Yuki   +48 more
wiley   +1 more source

The Emerging Roles of Viroporins in ER Stress Response and Autophagy Induction during Virus Infection

Viruses, 2015
Viroporins are small hydrophobic viral proteins that oligomerize to form aqueous pores on cellular membranes. Studies in recent years have demonstrated that viroporins serve important functions during virus replication and contribute to viral ...
To Sing Fung, Jaume Torres, Ding Xiang Liu   +2 more
doaj   +1 more source

Metabolic and mitochondria alterations induced by SARS‐CoV‐2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10

Journal of Medical Virology, Volume 96, Issue 7, July 2024.
Abstract Antiviral signaling, immune response and cell metabolism are dysregulated by SARS‐CoV‐2, the causative agent of COVID‐19. Here, we show that SARS‐CoV‐2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 induce a significant mitochondrial and metabolic reprogramming in A549 lung epithelial cells.
Blanca D. López‐Ayllón, Silvia Marin, Marco Fariñas Fernández, Tránsito García‐García, Raúl Fernández‐Rodríguez, Ana de Lucas‐Rius, Natalia Redondo, Laura Mendoza‐García, Carles Foguet, Juozas Grigas, Alba Calvet, José Manuel Villalba, María Josefa Rodríguez Gómez, Diego Megías, Biagio Mandracchia, Daniel Luque, Juan José Lozano, Cristina Calvo, Unai Merino Herrán, Timothy M. Thomson, Juan J. Garrido, Marta Cascante, María Montoya   +22 more
wiley   +1 more source

Targeting Endoplasmic Reticulum and/or Mitochondrial Ca2+ Fluxes as Therapeutic Strategy for HCV Infection

Frontiers in Chemistry, 2018
Chronic hepatitis C is characterized by metabolic disorders and by a microenvironment in the liver dominated by oxidative stress, inflammation and regeneration processes that can in the long term lead to liver cirrhosis and hepatocellular carcinoma ...
Rosella Scrima, Claudia Piccoli, Darius Moradpour, Nazzareno Capitanio   +3 more
doaj   +1 more source

Long COVID and post‐acute sequelae of SARS‐CoV‐2 pathogenesis and treatment: A Keystone Symposia report

Annals of the New York Academy of Sciences, Volume 1535, Issue 1, Page 31-41, May 2024.
Abstract In 2023, the Keystone Symposia held the first international scientific conference convening research leaders investigating the pathology of post‐acute sequelae of COVID‐19 (PASC) or Long COVID, a growing and urgent public health priority.
Matthew S. Durstenfeld, Shannon Weiman, Michael Holtzman, Catherine Blish, Resia Pretorius, Steven G. Deeks   +5 more
wiley   +1 more source

Viroporins and inflammasomes: A key to understand virus-induced inflammation

The International Journal of Biochemistry & Cell Biology, 2020
Viroporins are virus encoded proteins that alter membrane permeability and can trigger subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a hydrophilic pore which facilitates ion transport across host cell membranes.
Farag, N.S., Breitinger, U., Breitinger, H.G., El Azizi, M.A.   +3 more
openaire   +2 more sources

Transmembrane conformation of the envelope protein of an alpha coronavirus, NL63

Protein Science, Volume 33, Issue 4, April 2024.
Abstract The envelope (E) proteins of coronaviruses (CoVs) form cation‐conducting channels that are associated with the pathogenicity of these viruses. To date, high‐resolution structural information about these viroporins is limited to the SARS‐CoV E protein.
Iva Sučec, Yanina Pankratova, Mriganka Parasar, Mei Hong   +3 more
wiley   +1 more source

The Network of Interactions Between Classical Swine Fever Virus Nonstructural Protein p7 and Host Proteins

Frontiers in Microbiology, 2020
Classical swine fever (CSF) is a highly contagious viral disease causing severe economic losses to the swine industry. As viroporins of viruses modulate the cellular ion balance and then take over the cellular machinery, blocking the activity of ...
Jindai Fan, Jindai Fan, Jindai Fan, Mengru Zhang, Mengru Zhang, Mengru Zhang, Chenchen Liu, Chenchen Liu, Chenchen Liu, Mengjiao Zhu, Mengjiao Zhu, Mengjiao Zhu, Zilin Zhang, Zilin Zhang, Zilin Zhang, Keke Wu, Keke Wu, Keke Wu, Zhaoyao Li, Zhaoyao Li, Zhaoyao Li, Wenhui Li, Wenhui Li, Wenhui Li, Shuangqi Fan, Shuangqi Fan, Shuangqi Fan, Chunmei Ju, Chunmei Ju, Chunmei Ju, Lin Yi, Lin Yi, Lin Yi, Hongxing Ding, Hongxing Ding, Hongxing Ding, Mingqiu Zhao, Mingqiu Zhao, Mingqiu Zhao, Jinding Chen, Jinding Chen, Jinding Chen   +41 more
doaj   +1 more source