The minimalist architectures of viroporins and their therapeutic implications
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014 Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation. These viral proteins, collectively named viroporins, are crucial for viral pathogenicity.
OuYang, Bo, Chou, James J.
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Viruses, 2018 We have previously shown that Classical Swine Fever Virus (CSFV) p7 is an essential nonstructural protein with a viroporin activity, a critical function in the progression of virus infection. We also identified p7 domains and amino acid residues critical
Douglas P. Gladue +8 more
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The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin
PLoS Pathogens, 2010 Virus infections can result in a range of cellular injuries and commonly this involves both the plasma and intracellular membranes, resulting in enhanced permeability. Viroporins are a group of proteins that interact with plasma membranes modifying permeability and can promote the release of viral particles.
Suzuki, Tadaki +8 more
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Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses
, 2022 Xiaoyan Xia +16 more
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Development of a Plasmid-Based Reverse Genetics System for the Bluetongue and Epizootic Hemorrhagic Disease Viruses to Allow a Comparative Characterization of the Function of the NS3 Viroporin in Viral Egress [PDF]
, 2013 Marcelo Ehrlich +2 more
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The SAT Protein of the Minute Virus of Mice Induces the Lysis of the Cell through the Formation of Viroporin-like Structures [PDF]
, 2021 Clemens Bretscher
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Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein.
PLoS ONE, 2015 Viroporins are a family of low-molecular-weight hydrophobic transmembrane proteins that are encoded by various animal viruses. Viroporins form transmembrane pores in host cells via oligomerization, thereby destroying cellular homeostasis and inducing ...
Da Ao +10 more
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Viroporin-mediated Membrane Permeabilization [PDF]
Journal of Biological Chemistry, 2002 Aitziber Agirre +3 more
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Investigation of Molecular Mechanism of JC virus Viroporin Activity
Uirusu, 2015 Viroporins are small and hydrophobic viral proteins that form pores on host cell membranes, and their expression can increase the permeability of cellular membranes and the production of progeny virus particles. JC virus (JCV) is the causative agent of progressive multifocal leukoenchephalopathy (PML).
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