Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity [PDF]
mBio, 2010 Many viruses alter intracellular calcium homeostasis. The rotavirus nonstructural protein 4 (NSP4), an endoplasmic reticulum (ER) transmembrane glycoprotein, increases intracellular levels of cytoplasmic Ca2+ ([Ca2+]cyto) through a phospholipase C ...
Joseph M. Hyser +3 more
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Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals? [PDF]
Viruses, 2015 Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses.
Jamie Royle +3 more
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NLRP3 Inflammasome Activation by Viroporins of Animal Viruses [PDF]
Viruses, 2015 Viroporins are a group of low-molecular-weight proteins containing about 50–120 amino acid residues, which are encoded by animal viruses. Viroporins are involved in several stages of the viral life cycle, including viral gene replication and assembly ...
Hui-Chen Guo +4 more
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Identification and Structural Characterization of Viroporins from Deadly Hemorrhagic Viruses [PDF]
VirusesCrimean–Congo hemorrhagic fever virus (CCHF-V) and Ebola virus are lethal pathogens that cause widespread outbreaks of hemorrhagic fever. Both diseases can be transmitted through contact with the bodily fluids of infected individuals, but as an arbovirus,
Hiya Lahiri +2 more
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The citrus tristeza virus p33 protein functions as a viroporin. [PDF]
PLoS PathogensViroporins are viral proteins that form ion channels in the membranes of the host and, thus, alter the host ion homeostasis to create more favorable environments for the virus.
Vicken Aknadibossian +5 more
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The leader of the capsid protein from Feline calicivirus must be palmitoylated and form oligomers through disulfide bonds for efficient viral replication [PDF]
Journal of VirologyFeline calicivirus (FCV), a member of the genus Vesivirus and a model for studying members of the family Caliciviridae, has been used to understand the biology and viral replication of etiological agents of medical and veterinary importance.
Yoatzin Peñaflor-Téllez +7 more
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A hidden gene in astroviruses encodes a viroporin [PDF]
Nature Communications, 2020 Astroviruses are common human pathogens and their genomes contain three known protein-coding genes. Here, Lulla et al. report a fourth, previously overlooked gene encoding protein XP which has a viroporin-like activity that is important for efficient ...
Valeria Lulla, Andrew E. Firth
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Antiviral effect of the viroporin inhibitors against Taiwan isolates of infectious bronchitis virus (IBV) [PDF]
Virus ResearchCoronaviruses (CoVs) are significant animal and human pathogens, characterized by being enveloped RNA viruses with positive-sense single-stranded RNA. The Coronaviridae family encompasses four genera, among which gammacoronaviruses pose a major threat to
Mikael Cristofer Sitinjak +6 more
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Potential Viroporin Candidates From Pathogenic Viruses Using Bacteria-Based Bioassays [PDF]
Viruses, 2019 Viroporins are a family of small hydrophobic proteins found in many enveloped viruses that are capable of ion transport. Building upon the ability to inhibit influenza by blocking its archetypical M2 H+ channel, as a family, viroporins may represent a ...
Prabhat Pratap Singh Tomar +3 more
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Membrane Activity and Viroporin Assembly for the SARS-CoV-2 E Protein Are Regulated by Cholesterol [PDF]
BiomoleculesThe SARS-CoV-2 E protein is an enigmatic viral structural protein with reported viroporin activity associated with the acute respiratory symptoms of COVID-19, as well as the ability to deform cell membranes for viral budding.
Marta V. Volovik +4 more
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