COVID-19 ORF3a Viroporin Influenced Common and Unique Cellular Signalling Cascades in Lung, Heart and Brain Choroid Plexus Organoids with Additional Enriched MicroRNA Network Analyses for Lung and Brain Tissues [PDF]
, 2023 Chakraborty S +6 more
europepmc +2 more sources
Inhibitors of the small membrane (M) protein viroporin prevent Zika virus infection [PDF]
eLifeFlaviviruses, including Zika virus (ZIKV), are a significant global health concern, yet no licensed antivirals exist to treat disease. The small membrane (M) protein plays well-defined roles during viral egress and remains within virion membranes ...
Emma Brown +16 more
doaj +2 more sources
SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling [PDF]
Communications BiologyORF3a, the most abundantly expressed accessory protein of SARS-CoV-2, plays an essential role in virus egress by inactivating lysosomes through their deacidification. However, the mechanism underlying this process remains unclear.
Antonio Michelucci +9 more
doaj +2 more sources
The Small Cysteine-Rich Protein of Potato Mop-Top Virus Exhibits Viroporin Activity. [PDF]
Mol Plant PatholThe cysteine‐rich 8K protein of PMTV exhibits a viroporin activity that forms multimers on endomembrane, alters membrane permeability, and conducts potassium and protons. ABSTRACT Potato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Liu Y +9 more
europepmc +2 more sources
Coronavirus viroporins: structure and function [PDF]
The Ukrainian Biochemical Journal, 2021 Viroporins are involved in viral pathogenesis, play an important role in the morphogenesis of virions and ensure their release from the infected cell. These proteins are potentially promising as possible targets for the regulation of virus reproduction.
I. Zaloilo +3 more
openalex +3 more sources
The 6-kilodalton peptide 1 in plant viruses of the family Potyviridae is a viroporin. [PDF]
Proc Natl Acad Sci U S AChai M +12 more
europepmc +3 more sources
Computational investigation in inhibitory effects of amantadine on classical swine fever virus p7 ion channel activity [PDF]
Scientific ReportsClassical swine fever virus (CSFV) p7 viroporin plays crucial roles in cellular ion balance and permeabilization. The antiviral drug amantadine effectively inhibits viral replication by blocking the activity of CSFV p7 viroporin.
Xiaowei Chen, Xiao Wang
doaj +2 more sources
The virus-encoded ion channel “viroporin” activity of the agnoprotein is required for BK Polyomavirus release from infected kidney cells [PDF]
, 2023 Swinscoe G +8 more
europepmc +2 more sources
Pathophysiological Consequences of Calcium-Conducting Viroporins [PDF]
Annual Review of Virology, 2015 Eukaryotic cells have evolved a myriad of ion channels, transporters, and pumps to maintain and regulate transmembrane ion gradients. As intracellular parasites, viruses also have evolved ion channel proteins, called viroporins, which disrupt normal ionic homeostasis to promote viral replication and pathogenesis.
Joseph M. Hyser, Mary K. Estes
openalex +4 more sources
The SH protein of mumps virus is a druggable pentameric viroporin. [PDF]
Sci AdvDevantier K +15 more
europepmc +4 more sources