Results 31 to 40 of about 3,376 (179)
Vaccines, 2022 To improve the production of foot-and-mouth disease (FMD) molecular vaccines, we sought to understand the effects of the FMD virus (FMDV) 2B viroporin in an experimental, plasmid-based, virus-like particle (VLP) vaccine.
Victoria Primavera +4 more
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International Journal of Molecular Sciences, 2023 Mpox or monkeypox virus (MPXV) belongs to the subclass of Poxviridae and has emerged recently as a global threat. With a limited number of anti-viral drugs available for this new virus species, it is challenging to thwart the illness it begets. Therefore, characterizing new drug targets in the virus may prove advantageous to curbing the disease.
Kingshuk Basu +2 more
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FEBS Letters, 2003 Viroporins are a group of proteins that participate in several viral functions, including the promotion of release of viral particles from cells. These proteins also affect cellular functions, including the cell vesicle system, glycoprotein trafficking and membrane permeability.
Gonzalez Portal, Maria Eugenia +1 more
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Frontiers in Immunology, 2023 BackgroundCompared to healthy controls, severe COVID19 patients display increased levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 encodes viroporin proteins E and Orf3a(2-E+2-3a) with homologs to SARS-CoV-1, 1-E+1-3a,
Joseph W. Guarnieri +9 more
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Viroporins: structure and biological functions [PDF]
Nature Reviews Microbiology, 2012 Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically relevant animal viruses. When these proteins oligomerize in host cell membranes, they form hydrophilic pores that disrupt a number of physiological properties of the cell. Viroporins are crucial for viral pathogenicity owing to their involvement in several diverse
Nieva, José Luis +2 more
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Viroporins in the Influenza Virus [PDF]
Cells, 2019 Influenza is a highly contagious virus that causes seasonal epidemics and unpredictable pandemics. Four influenza virus types have been identified to date: A, B, C and D, with only A–C known to infect humans. Influenza A and B viruses are responsible for seasonal influenza epidemics in humans and are responsible for up to a billion flu infections ...
Janet To, Jaume Torres
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NS2A comprises a putative viroporin of Dengue virus 2 [PDF]
Virulence, 2017 During infection with Dengue virus (DENV), host cells undergo a series of detrimental functional changes, including profound remodelling and redistribution of cell membrane structures,1,4 which giv...
Gaurav Shrivastava +6 more
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Viroporin-like activity of the hairpin transmembrane domain of African swine fever virus B169L protein. [PDF]
J VirolGladue DP +9 more
europepmc +3 more sources
Advances in Viroporin Function and Structure: A Comparative Analysis of Alphavirus 6K with Well-Characterized Viroporins. [PDF]
VirusesViruses encode ion channel proteins called viroporins to assist in infection and immune evasion. The alphavirus 6K protein is classified as a member of the viroporin family of proteins. Several studies have characterized the role of 6K in alphavirus budding and infection since its discovery in the late 1970s.
Negi V, Miller AS, Kuhn RJ.
europepmc +3 more sources
Viroporin-mediated calcium-activated autophagy [PDF]
Autophagy, 2013 Autophagy is a cellular response activated by many pathogens, but the mechanism of activation is largely unknown. Recently we showed for the first time that rotavirus initiates the autophagy pathway through a calcium-mediated mechanism. Expression of the rotavirus-encoded NSP4, a pore-forming protein (viroporin), elicits the release of endoplasmic ...
Sue E, Crawford, Mary K, Estes
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