Results 41 to 50 of about 3,376 (179)
Membrane Integration of Poliovirus 2B Viroporin [PDF]
Journal of Virology, 2011 ABSTRACT Virus infections can result in a variety of cellular injuries, and these often involve the permeabilization of host membranes by viral proteins of the viroporin family. Prototypical viroporin 2B is responsible for the alterations in host cell membrane permeability that take place in enterovirus-infected cells. 2B protein
Martínez Gil, Luis +6 more
openaire +5 more sources
Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin Inhibitors
Frontiers in Microbiology, 2021 Severe acute respiratory syndrome coronavirus (SARS-CoV), an enveloped single-stranded positive-sense RNA virus, is a member of the genus Betacoronavirus, family Coronaviridae.
Ulrike Breitinger +3 more
doaj +1 more source
Viroporin activity of murine hepatitis virus E protein [PDF]
FEBS Letters, 2005 The viroporin activity of the E protein from murine hepatitis virus (MHV), a member of the coronaviruses, was analyzed. Viroporins are a growing family of viral proteins able to enhance membrane permeability, promoting virus budding. Initially, the MHV E gene was inducibly expressed in Escherichia coli cells, leading to the arrest of bacterial growth ...
Vanessa Madan +3 more
openalex +3 more sources
Viruses, 2021 ORF3a has been identified as a viroporin of SARS-CoV-2 and is known to be involved in various pathophysiological activities including disturbance of cellular calcium homeostasis, inflammasome activation, apoptosis induction and disruption of autophagy ...
Tyng Hwey Tan +5 more
doaj +1 more source
Angewandte Chemie, Volume 135, Issue 47, November 20, 2023., 2023 Viroporine sind kleine virale Ionenkanäle, die bei Virusinfektionen eine wesentliche Rolle spielen. Mittels oberflächenverstärkter Infrarotabsorptionsspektroskopie verfolgen und quantifizieren wir ausgedehnte Strukturveränderungen während der Öffnung des Influenza‐A‐Viroporins, des M2‐Protonenkanals, in einer Modellmembran.
Ronja Rabea Paschke +4 more
wiley +1 more source
In Support of Simian Polyomavirus 40 VP4 as a Later Expressed Viroporin
mSphere, 2020 Simian virus 40 VP4 was discovered in 2007 as a later expressed viral protein initiated from a downstream Met on the VP2/VP3 transcript. VP4’s role as a viroporin involved in viral release was supported in a series of additional articles that ...
Robert Daniels, Daniel N. Hebert
doaj +1 more source
Biomolecules, 2022 Background: SARS-CoV-2 has undergone mutations, yielding clinically relevant variants. Hypothesis: We hypothesized that in SARS-CoV-2, two highly conserved Orf3a and E channels directly related to the virus replication were a target for the detection and
Han-Gang Yu +3 more
doaj +1 more source
Angewandte Chemie International Edition, Volume 62, Issue 47, November 20, 2023., 2023 Viroporins are small viral ion channels that play essential roles during viral infections. Using surface‐enhanced infrared absorption spectroscopy we track and quantify the large‐scale structural changes during opening of the Influenza A viroporin, the M2 proton channel, in a model membrane.
Ronja Rabea Paschke +4 more
wiley +1 more source
Discovery and Characterization of the Phospholemman/SIMP/Viroporin Superfamily [PDF]
Microbial Physiology, 2022 Using bioinformatic approaches, we present evidence of distant relatedness among the Ephemerovirus Viroporin family, the Rhabdoviridae Putative Viroporin U5 family, the Phospholemman family, and the Small Integral Membrane Protein family. Our approach is based on the transitivity property of homology complemented with five validation criteria: (1 ...
Daniel Tyler +3 more
openaire +2 more sources
Viruses, 2019 Picornaviruses are associated with acute and chronic diseases. The clinical manifestations of infections are often mild, but infections may also lead to respiratory symptoms, gastroenteritis, myocarditis, meningitis, hepatitis, and poliomyelitis, with ...
Zengbin Li +4 more
doaj +1 more source