Results 51 to 60 of about 3,376 (179)

Ebola Virus Delta Peptide Is a Viroporin [PDF]

Journal of Virology, 2017
ABSTRACT The Ebola virus (EBOV) genome encodes a partly conserved 40-residue nonstructural polypeptide, called the delta peptide, that is produced in abundance during Ebola virus disease (EVD). The function of the delta peptide is unknown, but sequence analysis has suggested that delta peptide could be a viroporin, belonging to a diverse ...
Jing, He, Lilia I, Melnik, Alexander, Komin, Gregory, Wiedman, Taylor, Fuselier, Cameron F, Morris, Charles G, Starr, Peter C, Searson, William R, Gallaher, Kalina, Hristova, Robert F, Garry, William C, Wimley   +11 more
openaire   +2 more sources

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

eLife, 2020
Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine.
Joseph Shaw, Rajendra Gosain, Monoj Mon Kalita, Toshana L Foster, Jayakanth Kankanala, D Ram Mahato, Sonia Abas, Barnabas J King, Claire Scott, Emma Brown, Matthew J Bentham, Laura Wetherill, Abigail Bloy, Adel Samson, Mark Harris, Jamel Mankouri, David J Rowlands, Andrew Macdonald, Alexander W Tarr, Wolfgang B Fischer, Richard Foster, Stephen Griffin   +21 more
doaj   +1 more source

The US21 viroporin of human cytomegalovirus stimulates cell migration and adhesion

mBio, 2023
The human cytomegalovirus (HCMV) US12 gene family contributes to virus-host interactions by regulating the virus’ cell tropism and its evasion of host innate immune responses.
Anna Luganini, Valentina Serra, Giorgia Scarpellino, Shree Madhu Bhat, Luca Munaron, Alessandra Fiorio Pla, Giorgio Gribaudo   +6 more
doaj   +1 more source

Viroporins: structure, function and potential as antiviral targets [PDF]

Journal of General Virology, 2015
The channel-forming activity of a family of small, hydrophobic integral membrane proteins termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and DNA viruses, generating significant interest in targeting these proteins for antiviral development.
Scott, C, Griffin, S
openaire   +3 more sources

Modeling of the Ebola Virus Delta Peptide Reveals a Potential Lytic Sequence Motif

Viruses, 2015
Filoviruses, such as Ebola and Marburg viruses, cause severe outbreaks of human infection, including the extensive epidemic of Ebola virus disease (EVD) in West Africa in 2014. In the course of examining mutations in the glycoprotein gene associated with
William R. Gallaher, Robert F. Garry
doaj   +1 more source

Viral Membrane Channels: Role and Function in the Virus Life Cycle

Viruses, 2015
Viroporins are small, hydrophobic trans-membrane viral proteins that oligomerize to form hydrophilic pores in the host cell membranes. These proteins are crucial for the pathogenicity and replication of viruses as they aid in various stages of the viral ...
ChingWooen Sze, Yee-Joo Tan
doaj   +1 more source

The Genetic Stability, Replication Kinetics and Cytopathogenicity of Recombinant Avian Coronaviruses with a T16A or an A26F Mutation within the E Protein Is Cell-Type Dependent

Viruses, 2022
The envelope (E) protein of the avian coronavirus infectious bronchitis virus (IBV) is a small-membrane protein present in two forms during infection: a monomer and a pentameric ion channel.
Isobel Webb, Sarah Keep, Kieran Littolff, Jamie Stuart, Graham Freimanis, Paul Britton, Andrew D. Davidson, Helena J. Maier, Erica Bickerton   +8 more
doaj   +1 more source

Viroporins: Structures and functions beyond cell membrane permeabilization [PDF]

Viruses, 2015
Viroporins represent an interesting group of viral proteins that exhibit two sets of functions. First, they participate in several viral processes that are necessary for efficient production of virus progeny. [...]
José Nieva, Luis Carrasco
openaire   +5 more sources

Might proton pump or sodium‐hydrogen exchanger inhibitors be of value to ameliorate SARs‐CoV‐2 pathophysiology?

Physiological Reports, 2021
Discovering therapeutics for COVID‐19 is a priority. Besides high‐throughput screening of compounds, candidates might be identified based on their known mechanisms of action and current understanding of the SARs‐CoV‐2 life cycle.
Kirk P. Conrad
doaj   +1 more source

Viroporins from RNA viruses induce caspase-dependent apoptosis [PDF]

Cellular Microbiology, 2007
The virus-encoded viroporins are known to modify membrane permeability and play an essential role in virus budding. Here, a comparative analysis of the membrane permeabilization capacity of a number of viroporins was performed in baby hamster kidney cells.
Vanessa, Madan, Alfredo, Castelló, Luis, Carrasco   +2 more
openaire   +2 more sources