Results 61 to 70 of about 3,376 (179)

The Feline Calicivirus Leader of the Capsid Protein Has the Functional Characteristics of a Viroporin

Viruses, 2022
The leader of the capsid (LC) protein is exclusive to the Vesivirus genus, and it is needed for successful feline calicivirus (FCV) replication, as well as an efficient apoptosis induction through the mitochondrial pathway.
Yoatzin Peñaflor-Téllez, Bibiana Chávez-Munguía, Anel Lagunes-Guillén, Lizbeth Salazar-Villatoro, Ana Lorena Gutiérrez-Escolano   +4 more
doaj   +1 more source

Viroporins Customize Host Cells for Efficient Viral Propagation [PDF]

DNA and Cell Biology, 2013
Viruses are intracellular parasites that must access the host cell machinery to propagate. Viruses hijack the host cell machinery to help with entry, replication, packaging, and release of progeny to infect new cells. To carry out these diverse functions, viruses often transform the cellular environment using viroporins, a growing class of viral ...
Kristina M, Giorda, Daniel N, Hebert
openaire   +2 more sources

Viroporins Manipulate Cellular Powerhouses and Modulate Innate Immunity. [PDF]

Viruses
Viruses have a wide repertoire of molecular strategies that focus on their replication or the facilitation of different stages of the viral cycle. One of these strategies is mediated by the activity of viroporins, which are multifunctional viral proteins that, upon oligomerization, exhibit ion channel properties with mild ion selectivity.
Cedillo-Barrón L, García-Cordero J, Visoso-Carvajal G, León-Juárez M.   +3 more
europepmc   +4 more sources

Virtual Screening Identifies Chebulagic Acid as an Inhibitor of the M2(S31N) Viral Ion Channel and Influenza A Virus

Molecules, 2020
The increasing prevalence of drug-resistant influenza viruses emphasizes the need for new antiviral countermeasures. The M2 protein of influenza A is a proton-gated, proton-selective ion channel, which is essential for influenza replication and an ...
Maggie C. Duncan, Pascal Amoa Onguéné, Ibuki Kihara, Derrick N. Nebangwa, Maya E. Naidu, David E. Williams, Aruna D. Balgi, Kerstin Andrae-Marobela, Michel Roberge, Raymond J. Andersen, Masahiro Niikura, Fidele Ntie-Kang, Ian Tietjen   +12 more
doaj   +1 more source

Calicivirus Non-structural Proteins: Potential Functions in Replication and Host Cell Manipulation

Frontiers in Microbiology, 2021
The Caliciviridae are a family of viruses with a single-stranded, non-segmented RNA genome of positive polarity. The ongoing discovery of caliciviruses has increased the number of genera in this family to 11 (Norovirus, Nebovirus, Sapovirus, Lagovirus ...
Elena Smertina, Elena Smertina, Robyn N. Hall, Robyn N. Hall, Nadya Urakova, Tanja Strive, Tanja Strive, Michael Frese, Michael Frese   +8 more
doaj   +1 more source

Mechanisms of membrane permeabilization by picornavirus 2B viroporin [PDF]

FEBS Letters, 2003
Cell infection by picornaviruses leads to membrane permeabilization. Recent evidence suggests the involvement of the non‐structural protein 2B in this process. We have recently reported the detection of 2B porin‐like activity in isolated membrane–protein systems that lack other cell components. According to data derived from these model membranes, four
Nieva, José L., Agirre, Aitziber, Nir, Shlomo, Carrasco, Luis   +3 more
openaire   +2 more sources

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

PLoS Pathogens, 2012
Nod-like receptors (NLRs) comprise a large family of intracellular pattern- recognition receptors. Members of the NLR family assemble into large multiprotein complexes, termed the inflammasomes. The NLR family, pyrin domain-containing 3 (NLRP3) is triggered by a diverse set of molecules and signals, and forms the NLRP3 inflammasome. Recent studies have
Minako Ito, Yusuke Yanagi, Takeshi Ichinohe   +2 more
openaire   +4 more sources

Membrane-Active Peptides Derived from Picornavirus 2B Viroporin

Current Protein & Peptide Science, 2012
Viruses have evolved membrane-restructuring mechanisms for sustaining entry into cells, genome replication and release from host cells. Picornavirus 2B, a non-structural protein required for effective viral replication, functions as a potent intracellular pore-forming toxin by altering the permeability of cellular endomembranes.
Sánchez-Martínez, Silvia, Madan, Vanesa, Carrasco Llamas, Luis, Nieva, José Luis   +3 more
openaire   +3 more sources

Regulation of the ER Stress Response by the Ion Channel Activity of the Infectious Bronchitis Coronavirus Envelope Protein Modulates Virion Release, Apoptosis, Viral Fitness, and Pathogenesis

Frontiers in Microbiology, 2020
Coronavirus (CoV) envelope (E) protein is a small structural protein critical for virion morphogenesis and release. The recently characterized E protein ion channel activity (EIC) has also been implicated in modulating viral pathogenesis.
Shumin Li, Lixia Yuan, Guo Dai, Rui Ai Chen, Rui Ai Chen, Ding Xiang Liu, To Sing Fung   +6 more
doaj   +1 more source

Assessing the Impact of Colchicine on Pulmonary Fibrosis Using Imaging in Patients With Moderate‐to‐Severe COVID‐19 Pneumonia

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Objective Pulmonary fibrosis may develop in patients with severe clinical conditions, especially those with high inflammatory indicators. We aimed to investigate the 15‐month follow‐up clinical outcomes in patients with moderate‐to‐severe COVID‐19 pneumonia treated with colchicine and to evaluate its potential in preventing post‐COVID pulmonary ...
Gulhan Ayhan Albayrak, Mustafa Ilteris Bardakci, Ugur Temel, Karuna Sharma   +3 more
wiley   +1 more source