Results 71 to 80 of about 3,376 (179)
Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
Frontiers in Microbiology, 2019 Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that influenza virus M2 or encephalomyocarditis virus (EMCV) 2B proteins stimulate
I-Yin Chen +3 more
doaj +1 more source
Zika M—A Potential Viroporin: Mutational Study and Drug Repurposing
Biomedicines, 2022 Genus Flavivirus contains several important human pathogens. Among these, the Zika virus is an emerging etiological agent that merits concern. One of its structural proteins, prM, plays an essential role in viral maturation and assembly, making it an attractive drug and vaccine development target.
Prabhat Pratap Singh Tomar +3 more
openaire +3 more sources
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
A metastasis‐associated pannexin‐1 mutant (Panx11‐89) forms a minimalist ATP release channel
The FEBS Journal, Volume 292, Issue 13, Page 3378-3396, July 2025.A truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Junjie Wang +5 more
wiley +1 more source
Targeting the Channel Activity of Viroporins
, 2016 Since the discovery that certain small viral membrane proteins, collectively termed as viroporins, can permeabilize host cellular membranes and also behave as ion channels, attempts have been made to link this feature to specific biological roles. In parallel, most viroporins identified so far are virulence factors, and interest has focused toward the ...
To, Janet, Surya, Wahyu, Torres, Jaume
openaire +2 more sources
Ion Channel Activity of Vpu Proteins Is Conserved throughout Evolution of HIV-1 and SIV
Viruses, 2016 The human immunodeficiency virus type 1 (HIV-1) protein Vpu is encoded exclusively by HIV-1 and related simian immunodeficiency viruses (SIVs). The transmembrane domain of the protein has dual functions: it counteracts the human restriction factor ...
Timo Greiner +7 more
doaj +1 more source
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi +9 more
wiley +1 more source
Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses
Journal of Inflammation Research, 2021 SK Mohiuddin Choudhury,* XuSheng Ma,* Sahibzada Waheed Abdullah, HaiXue Zheng State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture ...
Choudhury SM, Ma X, Abdullah SW, Zheng H
doaj
In-situ spectroscopic detection of large-scale reorientations of transmembrane α-helices during viroporin channel opening [PDF]
, 2023 Ronja Rabea Paschke +4 more
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Transcription Kinetics in the Coronavirus Life Cycle
WIREs RNA, Volume 16, Issue 1, January/February 2025.The steps involved in a Coronavirus infection are interconnected and exhibit complex kinetics, with some processes depending on each other, while others occur independently. Understanding the basic kinetics of major processes like translation, transcription, and virion assembly in the Coronavirus life cycle adds temporal resolution to the classical ...
Katarzyna Grelewska‐Nowotko +2 more
wiley +1 more source