Results 81 to 90 of about 3,376 (179)
Plum pox virus: An overview of the potyvirus behind sharka, a harmful stone fruit disease
Annals of Applied Biology, Volume 186, Issue 1, Page 49-75, January 2025.Plum pox virus is a member of the genus Potyvirus in the family Potyviridae. The significance of this virus is underscored by its large strain diversity, wide host range, broad geographical distribution and the great socio‐economic impact of sharka, the disease it causes. Abstract The study of Potyvirus plumpoxi (plum pox virus, PPV) has a long history,
Juan Antonio García +5 more
wiley +1 more source
, 2015 Virus encoded ion channels, termed viroporins, are expressed by a diverse set of viruses and have been found to target nearly every host cell membrane and compartment, including endocytic/exocytic vesicles, ER, mitochondria, Golgi, and the plasma membrane. Viroporins are generally very small (
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The Interplay Between Viral Infection and Cell Death: A Ping‐Pong Effect
Advances in Virology, Volume 2025, Issue 1, 2025.Programmed cell death (PCD) is a well‐studied cellular mechanism that plays a critical role in immune responses, developmental processes, and the maintenance of tissue homeostasis. However, viruses have developed diverse strategies to bypass or manipulate the host apoptotic machinery to enhance their replication and survival.
Alireza Nourazarian +5 more
wiley +1 more source
Mouse polyomavirus infection induces lamin reorganisation
The FEBS Journal, Volume 291, Issue 23, Page 5133-5155, December 2024.Here, we investigated the roles of lamins as important nuclear proteins in the replication cycle of the mouse polyomavirus. We detected accumulation of the major capsid protein VP1 under the nuclear lamina, defects in nuclear lamina staining and different lamin A/C phosphorylation patterns following viral infection.
Kateřina Bruštíková +5 more
wiley +1 more source
Beyond Channel Activity: Protein-Protein Interactions Involving Viroporins [PDF]
, 2018 Viroporins are short polypeptides encoded by viruses. These small membrane proteins assemble into oligomers that can permeabilize cellular lipid bilayers, disrupting the physiology of the host to the advantage of the virus. Consequently, efforts during the last few decades have been focused towards the discovery of viroporin channel inhibitors, but in ...
To, Janet, Torres, Jaume
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VirusesThe open reading frame 3a (ORF3a) is a protein important to the pathogenicity of SARS-CoV-2. The cytoplasmic domain of ORF3a has three canonical tyrosine-based sorting signals (160YNSV163, 211YYQL213, and 233YNKI236), and a previous study has indicated ...
Edward B. Stephens +12 more
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Computational and Structural Biotechnology Journal, 2022 The hepatitis C virus (HCV) p7 viroporin protein is essential for viral assembly and release, suggesting its unrealised potential as a target for HCV interventions. Several classes of small molecules that can inhibit p7 through allosteric mechanisms have
Shukun Wei +7 more
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Emerging Therapeutics in the Fight Against EV‐D68: A Review of Current Strategies
Influenza and Other Respiratory Viruses, Volume 18, Issue 12, December 2024.ABSTRACT Enterovirus‐D68 (EV‐D68) was first identified in 1962 in pediatric patients with acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV‐D68 was underestimated due to limited data and serotyping methods. In 2014, the United States experienced outbreaks of acute flaccid myelitis (AFM) in children EV‐D68 positive.
Nida Kalam +1 more
wiley +1 more source
Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39
British Journal of Pharmacology, Volume 181, Issue 22, Page 4450-4490, November 2024.Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier +4 more
wiley +1 more source
Journal of Medical Virology, Volume 96, Issue 9, September 2024.Abstract Mitochondria are vital for most cells' functions. Viruses hijack mitochondria machinery for misappropriation of energy supply or to bypass defense mechanisms. Many of these mitochondrial dysfunctions persist after recovery from treated or untreated viral infections, particularly when mitochondrial DNA is permanently damaged.
Laetitia Gay +6 more
wiley +1 more source