Results 31 to 40 of about 375,491 (348)

Exploring the Evolution of Virulence Factors through Bioinformatic Data Mining

mSystems, 2019
The molecular evolution of virulence factors is a central theme in our understanding of bacterial pathogenesis and host-microbe interactions. Using bioinformatics and genome data mining, recent studies have shed light on the evolution of important ...
Andrew C. Doxey, Michael J. Mansfield, Briallen Lobb   +2 more
doaj   +1 more source

TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4

Nature Communications, 2021
TcpC is a well characterised multifunctional virulence factor expressed by uropathogenic Eschericia coli. Here the authors show that TcpC also targets neutrophil NETosis via its E3 ligase functionality promoting the degradation of PAD4, and represents an
Qian Ou, Jia-qi Fang, Zhe-sheng Zhang, Zhe Chi, Jie Fang, Di-yan Xu, Kai-zhong Lu, Meng-qing Qian, Da-yong Zhang, Jun-ping Guo, Wei Gao, Na-ru Zhang, Jian-ping Pan   +12 more
doaj   +1 more source

SARS-CoV-2 ORF8 accessory protein is a virulence factor

mBio, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes six accessory proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in pathogenesis.
M. Bello-Perez, J. Hurtado-Tamayo, A. Z. Mykytyn, M. M. Lamers, R. Requena-Platek, D. Schipper, D. Muñoz-Santos, J. Ripoll-Gómez, A. Esteban, P. J. Sánchez-Cordón, L. Enjuanes, B. L. Haagmans, I. Sola   +12 more
doaj   +1 more source

Trypanosoma brucei metacaspase 4 is a pseudopeptidase and a virulence factor [PDF]

, 2011
Metacaspases are caspase family cysteine peptidases found in plants, fungi, and protozoa but not mammals. Trypanosoma brucei is unusual in having five metacaspases (MCA1-MCA5), of which MCA1 and MCA4 have active site substitutions, making them possible ...
Absalon, Alsford, Ambit, Bangs, Bastin, Belenghi, Birkett, Bozhkov, Broadhead, Burleigh, Coll, Emmer, Emmer, Emmer, Field, Geiger, Grébaut, Helms, Kelly, LaCount, Lee, Lee, Liu, Madeo, Mills, Morty, Moss, Mottram, Munday, Pils, Pop, Silverman, Sundström, Szallies, Sárkány, Tsiatsiani, Uren, Vercammen, Watanabe, Webb, Wirtz, Yu, Zalila, Zettl   +43 more
core   +3 more sources

Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation [PDF]

, 2020
The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Deletion of a gene encoding a putative deacetylase, Agd3, leads to defects in GAG deacetylation, biofilm formation, and ...
A Ghafoor, A Morin, AB Boraston, AW Blake, C Bundalovic-Torma, C Guerrero, C Ryder, C Steentoft, C Vuong, CM Payne, Collaborative Computational Project Number 4., CS Cummins, DC Sheppard, DE Blair, DE Blair, DJ Little, DJ Little, DJ Little, E Andrés, E Potterton, EN Kitova, F Le Mauff, F Sievers, FN Gravelat, FN Gravelat, GB Whitfield, GD Brown, GM Sheldrick, GM Sheldrick, H Aragunde, H Ashkenazy, H Ostapska, H Takada, H Zakariassen, J Hoßbach, J Sun, JA Jorge, JA Jorge, JJ Distler, JJ Tesmer, JL Reissig, JW Jensen, K Miyazawa, K Mizutani, KM Colvin, LA Kelley, LK Jennings, LS Marmont, M Gonzalez, M Oda, M Strong, MD Winn, MJ Lee, MJ Lee, MM Shaik, N Nwe, NA Baker, NC Bamford, NC Bamford, P Emsley, P Ruperez, P Vasseur, PC Bardalaye, PD Adams, PD Adams, RC Edgar, RE Lewis, S Jana, S Kaur, S Kumar, SC Potter, SF Altschul, T Fontaine, T Inoue, V Pokrovskaya, VE Fadouloglou, VK Köseoğlu, W Vollmer, W Wang, X Wang, X-L Li, Y Araki, Y Itoh, Y Kidani, Y Kidani   +84 more
core   +3 more sources

Phytohormone-mediated interkingdom signaling shapes the outcome of rice-Xanthomonas oryzae pv. oryzae interactions [PDF]

, 2015
Background: Small-molecule hormones are well known to play key roles in the plant immune signaling network that is activated upon pathogen perception. In contrast, little is known about whether phytohormones also directly influence microbial virulence ...
De Vleesschauwer, David, He, Ya-Wen, Höfte, Monica, Kojima, Mikiko, Sakakibari, Hitoshi, Venturi, Vittorio, Xu, Jing, Zhou, Lian   +7 more
core   +2 more sources

Prediction of Burkholderia pseudomallei DsbA substrates identifies potential virulence factors and vaccine targets.

PLoS ONE, 2020
Identification of bacterial virulence factors is critical for understanding disease pathogenesis, drug discovery and vaccine development. In this study we used two approaches to predict virulence factors of Burkholderia pseudomallei, the Gram-negative ...
Ben Vezina, Guillaume A Petit, Jennifer L Martin, Maria A Halili   +3 more
doaj   +1 more source

ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosis

Biomolecules, 2023
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), is one of the most successfully adapted human pathogens. Human-to-human transmission occurs at high rates through aerosols containing bacteria, but the pathogen evolved ...
Elsa Anes, David Pires, Manoj Mandal, José Miguel Azevedo-Pereira   +3 more
doaj   +1 more source

Identification of an essential virulence gene of cyprinid herpesvirus 3 [PDF]

, 2017
The genus Cyprinivirus consists of a growing list of phylogenetically related viruses, some of which cause severe economic losses to the aquaculture industry. The archetypal member, cyprinid herpesvirus 3 (CyHV-3) causes mass mortalities worldwide in koi
Boutier, Maxime, Davison, Andrew J., Gao, Yuan, Suárez, Nicolás, Vancsok, Catherine, Vanderplasschen, Alain   +5 more
core   +2 more sources

Phosphorylation of CFP10 modulates Mycobacterium tuberculosis virulence

mBio, 2023
Virulence effectors secreted by Mycobacterium tuberculosis (Mtb) help subvert host immune mechanisms and, therefore, are critical for establishing infection and pathogenesis. However, knowledge in terms of signaling mechanisms that modulate the secretion
Basanti Malakar, Komal Chauhan, Priyadarshini Sanyal, Saba Naz, Haroon Kalam, R. P. Vivek-Ananth, Lakshya Veer Singh, Areejit Samal, Dhiraj Kumar, Vinay Kumar Nandicoori   +9 more
doaj   +1 more source