Results 101 to 110 of about 13,827 (215)

Disorder-to-Order Transition in the CyaA Toxin RTX Domain: Implications for Toxin Secretion

Toxins, 2014
The past decade has seen a fundamental reappraisal of the protein structure-to-function paradigm because it became evident that a significant fraction of polypeptides are lacking ordered structures under physiological conditions.
Ana-Cristina Sotomayor-Pérez, Daniel Ladant, Alexandre Chenal   +2 more
doaj   +1 more source

Immunity Switches and Macrophage Manipulations: Trauma, Ovulation, and Depression as Latent Tuberculosis Reactivation Risks

American Journal of Human Biology, Volume 37, Issue 9, September 2025.
ABSTRACT Inflammation is the immune system's natural response to initial tuberculosis infection. Tuberculosis bacteria have gained adaptations to manipulate the inflammatory process, sometimes settling into latency and containment in granulomas, ensuring their survival.
Stacie Burke
wiley   +1 more source

Expression of adhesins by some “Bordetella pertussis” strains isolated in Romania in different time periods

Studia Universitatis Babeș-Bolyai. Biologia, 2018
Bordetella pertussis is the etiological agent of whooping cough or pertussis, a respiratory infection in humans which can be prevented by vaccination. B.
Georgeta Cristina OPREA, Veronica LAZĂR
doaj   +1 more source

Direct Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli and Salmonella-Typhimurium Aroa [PDF]

, 1991
Nonfused (i.e., nonhybrid) filamentous hemagglutinin (FHA) of Bordetella pertussis was efficiently expressed in Escherichia coli K-12 and Salmonella typhimurium aroA at levels higher than those found in wild-type B. pertussis when the upstream signals of
Guzman, Carlos A., Rohde, Manfred, Timmis, Kenneth N., Walker, Mark J.   +3 more
core  

Structure of HrcQ(B)-C, a conserved component of the bacterial type III secretion systems [PDF]

, 2003
Type III secretion systems enable plant and animal bacterial pathogens to deliver virulence proteins into the cytosol of eukaryotic host cells, causing a broad spectrum of diseases including bacteremia, septicemia, typhoid fever, and bubonic plague in ...
A. P. Tampakaki, Alfano, Anderson, Br  nger, Charkowski, Collmer, Fadouloglou, Francis, Galan, Garcia de la Torre, Gouet, Hueck, J. M. Hadden, Jin, Kubori, Landgraf, Lloyd, Luo, M. Kokkinidis, M. N. Bastaki, Mathews, McGuffin, Murshudov, N. J. Panopoulos, N. M. Glykos, Rossier, S. E. Phillips, Stebbins, Tamano, Tang, Terwilliger, Terwilliger, V. E. Fadouloglou, Zhao   +33 more
core   +2 more sources

Outer Membrane Vesicles as a Versatile Platform for Vaccine Development: Engineering Strategies, Applications and Challenges

Journal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Outer membrane vesicles (OMVs) are nanosized vesicles naturally secreted by Gram‐negative bacteria and represent a promising platform for vaccine development. OMVs possess inherent immunostimulatory properties due to the presence of pathogen‐associated molecular patterns (PAMPs), providing self‐adjuvanting capabilities and the ability to ...
Asja Garling, Frédéric Auvray, Mathieu Epardaud, Éric Oswald, Priscilla Branchu   +4 more
wiley   +1 more source

Genome implosion elicits host-confinement in Alcaligenaceae: evidence from the comparative genomics of Tetrathiobacter kashmirensis, a pathogen in the making.

PLoS ONE, 2013
This study elucidates the genomic basis of the evolution of pathogens alongside free-living organisms within the family Alcaligenaceae of Betaproteobacteria. Towards that end, the complete genome sequence of the sulfur-chemolithoautotroph Tetrathiobacter
Wriddhiman Ghosh, Masrure Alam, Chayan Roy, Prosenjit Pyne, Ashish George, Ranadhir Chakraborty, Saikat Majumder, Atima Agarwal, Sheolee Chakraborty, Subrata Majumdar, Sujoy Kumar Das Gupta   +10 more
doaj   +1 more source

Bordetella Type III Secretion Injectosome and Effector Proteins

Frontiers in Cellular and Infection Microbiology, 2020
Pertussis, also known as whooping cough, is a resurging acute respiratory disease of humans primarily caused by the Gram-negative coccobacilli Bordetella pertussis, and less commonly by the human-adapted lineage of B. parapertussisHU.
Jana Kamanova
doaj   +1 more source

Tripartite ATP-Independent Periplasmic (TRAP) Transporters and Tripartite Tricarboxylate Transporters (TTT): From Uptake to Pathogenicity [PDF]

, 2018
The ability to efficiently scavenge nutrients in the host is essential for the viability of any pathogen. All catabolic pathways must begin with the transport of substrate from the environment through the cytoplasmic membrane, a role executed by membrane
Bianconi, M.E., Kelly, D.J., Rosa, L.T., Thomas, G.H.   +3 more
core   +3 more sources

The Bordetella effector protein BteA induces host cell death by disruption of calcium homeostasis

mBio
Bordetella pertussis is the causative agent of whooping cough in humans, a disease that has recently experienced a resurgence. In contrast, Bordetella bronchiseptica infects the respiratory tract of various mammalian species, causing a range of symptoms ...
Martin Zmuda, Eliska Sedlackova, Barbora Pravdova, Monika Cizkova, Marketa Dalecka, Ondrej Cerny, Tania Romero Allsop, Tomas Grousl, Ivana Malcova, Jana Kamanova   +9 more
doaj   +1 more source