Results 81 to 90 of about 7,870 (170)

Disorder-to-Order Transition in the CyaA Toxin RTX Domain: Implications for Toxin Secretion

Toxins, 2014
The past decade has seen a fundamental reappraisal of the protein structure-to-function paradigm because it became evident that a significant fraction of polypeptides are lacking ordered structures under physiological conditions.
Ana-Cristina Sotomayor-Pérez, Daniel Ladant, Alexandre Chenal   +2 more
doaj   +1 more source

Genome implosion elicits host-confinement in Alcaligenaceae: evidence from the comparative genomics of Tetrathiobacter kashmirensis, a pathogen in the making.

PLoS ONE, 2013
This study elucidates the genomic basis of the evolution of pathogens alongside free-living organisms within the family Alcaligenaceae of Betaproteobacteria. Towards that end, the complete genome sequence of the sulfur-chemolithoautotroph Tetrathiobacter
Wriddhiman Ghosh, Masrure Alam, Chayan Roy, Prosenjit Pyne, Ashish George, Ranadhir Chakraborty, Saikat Majumder, Atima Agarwal, Sheolee Chakraborty, Subrata Majumdar, Sujoy Kumar Das Gupta   +10 more
doaj   +1 more source

The Bordetella effector protein BteA induces host cell death by disruption of calcium homeostasis

mBio
Bordetella pertussis is the causative agent of whooping cough in humans, a disease that has recently experienced a resurgence. In contrast, Bordetella bronchiseptica infects the respiratory tract of various mammalian species, causing a range of symptoms ...
Martin Zmuda, Eliska Sedlackova, Barbora Pravdova, Monika Cizkova, Marketa Dalecka, Ondrej Cerny, Tania Romero Allsop, Tomas Grousl, Ivana Malcova, Jana Kamanova   +9 more
doaj   +1 more source

The role of cytochrome oxidases in bacterial virulence

Infection and Immunity
Bacterial physiology plays an important role in virulence. Being a pathogen is energetically expensive, requiring the production of specialized virulence factors and other proteins that enable survival within the host. The most efficient way for bacteria
Liliana S. McKay, Andrew Camilli, Peggy A. Cotter   +2 more
doaj   +1 more source

Occurrence of Genes Encoding Virulence Factors in Bordetella Bronchiseptica Strains Isolated from Infected and Healthy Pigs

Bulletin of the Veterinary Institute in Pulawy, 2012
Abstract The objective of the study was to determine genotypic profiles of Bordetella bronchiseptica (Bbr) strains, based on the occurrence of genes encoding virulence factors, such as flagella (fla), dermonecrotoxin (dnt), and exogenous ferric siderophore receptor (bfrZ), using PCR.
Stepniewska, Katarzyna, Iwona Markowska-Daniel   +1 more
openaire   +1 more source

Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes

Toxins, 2017
Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and establishment of the disease.
Helena Ostolaza, César Martín, David González-Bullón, Kepa B. Uribe, Asier Etxaniz   +4 more
doaj   +1 more source

[Immunobiologic activity of Bordetella pertussis strains defective in various virulence factors].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1989
The immunobiological properties of mutant strains, selectively deprived of certain antigens (hemagglutinin, B. pertussis toxin, dermonecrotic toxin, hemolysin, adenylate cyclase), have been studied with the aim of finding out the relationship between the presence of certain antigens in microbial strains and their protective properties.
V D, Smirnov, R P, Chuprinina, R A, Siundiukova, R V, Maksiutov   +3 more
openaire   +1 more source

Characterizing the secretion and function of TcfA : a unique autotransporter and virulence factor in Bordetella pertussis

, 2018
Autotransporters (ATs) are an important family of proteins that are essential for the virulence of a variety of Gram-negative bacteria. The vast majority of ATs possess a classical right handed β-helical structure which facilitates the vectorial secretion of the protein. However, not all ATs possess this classical structure.
openaire   +1 more source

The Battle Against Pertussis: Discovery of Endogenous Human Proteins and Peptides as Toxin-Inhibitors. [PDF]

Toxins (Basel)
Lietz S, Barth H.
europepmc   +1 more source

The evolution of pertactin expression in Belgian circulating <i>B. pertussis</i> strains, pre- and post-COVID-19. [PDF]

Microbiol Spectr
Martini H, Soetens O, Niinikoski V, Barkoff A-M, He Q, Piérard D, Honacker EV.   +6 more
europepmc   +1 more source