Results 71 to 80 of about 7,528,433 (208)

Polymorphism inBordetella pertussisPertactin and Pertussis Toxin Virulence Factors in the United States, 1935–1999 [PDF]

The Journal of Infectious Diseases, 2000
To elucidate the potential role of the etiologic agent in recent increases of pertussis incidence in the United States, we studied the polymorphism in pertactin and pertussis toxin, which are Bordetella pertussis proteins important for pathogenesis and immunity. We sequenced regions of their genes (prn and ptx) in 152 B. pertussis strains isolated from
Cassiday, P, Sanden, G, Heuvelman, Krivm, Mooi, Frivm, Bisgard, KM, Popovic, T   +5 more
openaire   +4 more sources

Nuanced differences in adenylate cyclase toxin production, acylation, and secretion may contribute to the evolution of virulence in Bordetella species

mBio
Bordetella pertussis, which causes the acute human disease whooping cough, evolved from Bordetella bronchiseptica, which causes long-term, chronic infections in a broad range of mammals. Both B. pertussis and B.
Alexa R. Wolber, Liliana S. McKay, Katlyn B. Mote, Richard M. Johnson, Carol S. Inatsuka, Peggy A. Cotter   +5 more
doaj   +1 more source

Clinical and computed tomography findings of fatal poxviral vasculitis in a domestic shorthair cat

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract This report describes the clinical presentation, haematological abnormalities and imaging findings of systemic poxvirus infection in a cat that resulted in widespread severe dermal oedema and systemic inflammatory response syndrome. The cat lacked cutaneous lesions before the onset of dermal oedema, but developed crusting skin lesions and a ...
Mica Taylor, Harriet R. Hall, Hannah Wong, Lorraine Peschard, Emanuele Ricci, Katie E. McCallum   +5 more
wiley   +1 more source

Breaking the bad: Bacillus blocks fungal virulence factors

, 2017
Fungal pathogens rely on the production of specific virulence factors during infection. Inhibiting such factors generally results in reduced fungal pathogenicity.
James W. Kronstad, François L. Mayer
core   +1 more source

Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins [PDF]

, 2009
The cAMP signaling pathway is crucial for many physiological processes and many disease states like neurodegenerative diseases, mood disorders, pain, drug dependency or heart failure.
Göttle, Martin
core   +1 more source

Allelic variations between vaccine strains and circulating strains in pxtP of Bordetella pertussis in Iran

Vaccine Research, 2015
Introduction: Despite high level of vaccination against pertussis‚ whooping cough has re-emerged as a health threat, especially in infants. This could be related to expansion of Bordetella pertussis with novel alleles for virulence factors including the ...
F Sadeghpour Heravi, VS Nikbin, F Shahcheraghi   +2 more
doaj  

Characterization of Post-Translational Modifications and Cytotoxic Properties of the Adenylate-Cyclase Hemolysin Produced by Various Bordetella pertussis and Bordetella parapertussis Isolates

Toxins, 2017
Bordetella pertussis and Bordetella parapertussis are the causal agents of whooping cough in humans. They produce diverse virulence factors, including adenylate cyclase-hemolysin (AC-Hly), a secreted toxin of the repeat in toxins (RTX) family with ...
Valérie Bouchez, Thibaut Douché, Mélody Dazas, Sophie Delaplane, Mariette Matondo, Julia Chamot-Rooke, Nicole Guiso   +6 more
doaj   +1 more source

The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model.

PLoS Pathogens, 2022
Pulmonary infections caused by Bordetella pertussis used to be the prime cause of infant mortality in the pre-vaccine era and mouse models of pertussis pneumonia served in characterization of B. pertussis virulence mechanisms.
Jana Holubova, Ondrej Stanek, Attila Juhasz, Illiassou Hamidou Soumana, Peter Makovicky, Peter Sebo   +5 more
doaj   +1 more source

Orthoquinone, Cyclic, and Acyclic α‐Diketone Natural Products: From Food Applications to Pharmacotherapy

Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.
The orthoquinone metabolites from plants have antimicrobial, antioxidant, antiviral, cytotoxic, and anti‐inflammatory effects. ABSTRACT The structural diversity of natural products is vast and fascinating, and they have been recognized as an enormously diverse source of new lead compounds.
Hidayat Hussain, Daijie Wang, Satyajit D. Sarker, Lutfun Nahar, Nilufar Z. Mamadalieva, Jianbo Xiao   +5 more
wiley   +1 more source

Variation in the Bordetella pertussis Virulence Factors Pertussis Toxin and Pertactin in Vaccine Strains and Clinical Isolates in Finland [PDF]

Infection and Immunity, 1999
ABSTRACT There is evidence that pertussis is reemerging in vaccinated populations. We have proposed, and provided evidence for, one explanation for this phenomenon in The Netherlands: antigenic divergence between vaccine strains and circulating strains.
Mooi, FR, He, Q, van Oirschot, H, Mertsola, J   +3 more
openaire   +4 more sources