Results 1 to 10 of about 421,443 (284)

Identifying Effective Antiviral Drugs Against SARS-CoV-2 by Drug Repositioning Through Virus-Drug Association Prediction [PDF]

Frontiers in Genetics, 2020
A new coronavirus called SARS-CoV-2 is rapidly spreading around the world. Over 16,558,289 infected cases with 656,093 deaths have been reported by July 29th, 2020, and it is urgent to identify effective antiviral treatment.
Lihong Peng, Xiongfei Tian, Ling Shen, Ming Kuang, Tianbao Li, Geng Tian, Jialiang Yang, Liqian Zhou   +7 more
doaj   +5 more sources

Probing antiviral drugs against SARS-CoV-2 through virus-drug association prediction based on the KATZ method. [PDF]

Genomics, 2020
It is urgent to find an effective antiviral drug against SARS-CoV-2. In this study, 96 virus-drug associations (VDAs) from 12 viruses including SARS-CoV-2 and similar viruses and 78 small molecules are selected. Complete genomic sequence similarity of viruses and chemical structure similarity of drugs are then computed.
Zhou L, Wang J, Liu G, Lu Q, Dong R, Tian G, Yang J, Peng L.   +7 more
europepmc   +3 more sources

GiGs: graph-based integrated Gaussian kernel similarity for virus-drug association prediction. [PDF]

Brief Bioinform
Abstract The prediction of virus–drug associations (VDAs) is crucial for drug repositioning, contributing to the identification of latent antiviral drugs. In this study, we developed a graph-based integrated Gaussian kernel similarity (GiGs) method for predicting potential VDAs in drug repositioning.
Jin Y, Huang J, Sun X, Fang Y, Wu J, Du J, Jia J, Wang G.   +7 more
europepmc   +3 more sources

A new integrated framework for the identification of potential virus–drug associations

Frontiers in Microbiology, 2023
IntroductionWith the increasingly serious problem of antiviral drug resistance, drug repurposing offers a time-efficient and cost-effective way to find potential therapeutic agents for disease.
Jia Qu, Zihao Song, Xiaolong Cheng, Zhibin Jiang, Jie Zhou   +4 more
doaj   +3 more sources

Discovery of Potential Therapeutic Drugs for COVID-19 Through Logistic Matrix Factorization With Kernel Diffusion

Frontiers in Microbiology, 2022
Coronavirus disease 2019 (COVID-19) is rapidly spreading. Researchers around the world are dedicated to finding the treatment clues for COVID-19. Drug repositioning, as a rapid and cost-effective way for finding therapeutic options from available FDA ...
Xiongfei Tian, Ling Shen, Pengfei Gao, Li Huang, Li Huang, Guangyi Liu, Liqian Zhou, Lihong Peng, Lihong Peng   +8 more
doaj   +1 more source

Screening Potential Drugs for COVID-19 Based on Bound Nuclear Norm Regularization

Frontiers in Genetics, 2021
The novel coronavirus pneumonia COVID-19 infected by SARS-CoV-2 has attracted worldwide attention. It is urgent to find effective therapeutic strategies for stopping COVID-19.
Juanjuan Wang, Chang Wang, Ling Shen, Liqian Zhou, Lihong Peng, Lihong Peng   +5 more
doaj   +1 more source

Drug repositioning for SARS-CoV-2 by Gaussian kernel similarity bilinear matrix factorization

Frontiers in Microbiology, 2022
Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently spreading rapidly around the world.
Yibai Wang, Ju Xiang, Ju Xiang, Cuicui Liu, Min Tang, Rui Hou, Rui Hou, Meihua Bao, Meihua Bao, Geng Tian, Geng Tian, Jianjun He, Jianjun He, Jianjun He, Binsheng He, Binsheng He, Binsheng He   +16 more
doaj   +1 more source

Association between Adherence to Antiretroviral Therapy and Human Immunodeficiency Virus Drug Resistance [PDF]

Clinical Infectious Diseases, 2003
Nonadherence to highly active antiretroviral therapy (HAART) is a major cause of human immunodeficiency virus (HIV) drug resistance; however the level of nonadherence associated with the greatest risk of resistance is unknown. Beginning in February 2000, 195 patients at the Johns Hopkins Outpatient Center (Baltimore, MD) who were receiving HAART and ...
Ajay K, Sethi, David D, Celentano, Stephen J, Gange, Richard D, Moore, Joel E, Gallant   +4 more
openaire   +2 more sources

Hepatitis C virus drug resistance–associated substitutions: State of the art summary [PDF]

Hepatology, 2015
Hepatitis C virus (HCV) drug development has resulted in treatment regimens composed of interferon‐free, all‐oral combinations of direct‐acting antivirals. While the new regimens are potent and highly efficacious, the full clinical impact of HCV drug resistance, its implications for retreatment, and the potential role of baseline ...
Erik, Lontok, Patrick, Harrington, Anita, Howe, Tara, Kieffer, Johan, Lennerstrand, Oliver, Lenz, Fiona, McPhee, Hongmei, Mo, Neil, Parkin, Tami, Pilot-Matias, Veronica, Miller   +10 more
openaire   +2 more sources

Viral exanthems in childhood. Part 3: Parainfectious exanthems and those associated with virus‐drug interactions [PDF]

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2009
SummaryViruses cause not only direct infectious exanthems, but also parainfectious exanthems, which provoke skin alterations via interactions with the immune system. These distinct exanthems, for instance Gianotti‐Crosti syndrome and pityriasis lichenoides group, do not reflect a specific pathogen but can occur in the course of many viral infections ...
Regina, Fölster-Holst, Hans Wolfgang, Kreth   +1 more
openaire   +2 more sources