Results 11 to 20 of about 421,443 (284)

Discovering Drug-Drug Interactions Using Association Rule Mining from Electronic Health Records [PDF]

open access: yes, 2023
In this paper, we propose utilising Electronic Health Records (EHR) to discover previously unknown drug-drug interactions (DDI) that may result in high rates of hospital readmissions.
Chahed, S.   +4 more
core   +1 more source

Prioritizing antiviral drugs against SARS-CoV-2 by integrating viral complete genome sequences and drug chemical structures

open access: yesScientific Reports, 2021
The outbreak of a novel febrile respiratory disease called COVID-19, caused by a newfound coronavirus SARS-CoV-2, has brought a worldwide attention. Prioritizing approved drugs is critical for quick clinical trials against COVID-19.
Lihong Peng   +8 more
doaj   +1 more source

Gene Expression Signatures in AML-12 Hepatocyte Cells upon Dengue virus Infection and Acetaminophen Treatment

open access: yesViruses, 2020
Dengue is an acute viral disease caused by Dengue virus (DENV) and is considered to be the most common arbovirus worldwide. The clinical characteristics of dengue may vary from asymptomatic to severe complications and severe organ impairment ...
Jorge G. G. Ferreira   +6 more
doaj   +1 more source

A computational approach to aid clinicians in selecting anti-viral drugs for COVID-19 trials

open access: yesScientific Reports, 2021
The year 2020 witnessed a heavy death toll due to COVID-19, calling for a global emergency. The continuous ongoing research and clinical trials paved the way for vaccines.
Aanchal Mongia   +3 more
doaj   +1 more source

Cytokine (IL-10, IL-6, TNF-α and TGF-β1) Gene Polymorphisms in Chronic Hepatitis C Virus Infection among Malay Male Drug Abusers

open access: yesBiomedicines, 2021
Cytokines play an important role in modulating inflammation during viral infection, including hepatitis C virus (HCV) infection. Genetic polymorphisms of cytokines can alter the immune response against this infection.
Ismail Che Noh   +5 more
doaj   +1 more source

In Vitro Inhibition of Zika Virus Replication with Amantadine and Rimantadine Hydrochlorides

open access: yesMicrobiology Research, 2021
Zika virus (ZIKV) is a mosquito-borne flavivirus in which human infection became relevant during recent outbreaks in Latin America due to its unrecognized association with fetal neurological disorders.
Jorge L. Arias-Arias   +4 more
doaj   +1 more source

Repositioning Drugs on Human Influenza A Viruses Based on a Novel Nuclear Norm Minimization Method

open access: yesFrontiers in Physiology, 2021
Influenza A viruses, especially H3N2 and H1N1 subtypes, are viruses that often spread among humans and cause influenza pandemic. There have been several big influenza pandemics that have caused millions of human deaths in history, and the threat of ...
Hang Liang   +8 more
doaj   +1 more source

Sociodemographic, Ecological, and Spatiotemporal Factors Associated with Human Immunodeficiency Virus Drug Resistance in Florida: A Retrospective Analysis

open access: yesThe Journal of Infectious Diseases, 2020
Abstract Background Persons living with human immunodeficiency virus (HIV) with resistance to antiretroviral therapy are vulnerable to adverse HIV-related health outcomes and can contribute to transmission of HIV drug resistance (HIVDR) when nonvirally suppressed. The degree to which HIVDR contributes
Shannan N Rich   +7 more
openaire   +3 more sources

WLLP: A weighted reconstruction-based linear label propagation algorithm for predicting potential therapeutic agents for COVID-19

open access: yesFrontiers in Microbiology, 2022
The global coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV) has led to a huge health and economic crises.
Langcheng Chen   +4 more
doaj   +1 more source

Hepatitis C infection among injecting drug users in England and Wales (1992-2006): there and back again? [PDF]

open access: yes, 2009
Changes in hepatitis C virus (HCV) prevalence from 1992 to 2006 were examined by using 24,311 records from unlinked anonymous surveillance of injecting drug users in England and Wales.
Hope, Vivian D   +10 more
core   +1 more source

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