Results 11 to 20 of about 119,805 (200)

Enhancing Anti-SARS-CoV-2 Neutralizing Immunity by Genetic Delivery of Enveloped Virus-like Particles Displaying SARS-CoV-2 Spikes

Vaccines, 2023
New vaccine delivery technologies, such as mRNA, have played a critical role in the rapid and efficient control of SARS-CoV-2, helping to end the COVID-19 pandemic.
Yongping Yang, Wing-Pui Kong, Cuiping Liu, Tracy J. Ruckwardt, Yaroslav Tsybovsky, Lingshu Wang, Shuishu Wang, Daniel W. Biner, Man Chen, Tracy Liu, Jonah Merriam, Adam S. Olia, Li Ou, Qi Qiu, Wei Shi, Tyler Stephens, Eun Sung Yang, Baoshan Zhang, Yi Zhang, Qiong Zhou, Reda Rawi, Richard A. Koup, John R. Mascola, Peter D. Kwong   +23 more
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Development of Respiratory Syncytial Virus Vaccine Candidates for the Elderly

Viruses, 2023
Respiratory syncytial virus (RSV) is a significant threat to elderly populations and repeated infections that occur throughout life are poorly protective. To assess the role of prior RSV infections as well as elderly immune senescence on vaccine efficacy,
Jorge C. G. Blanco, Lori M. Cullen, Arash Kamali, Fatouomata Y. D. Sylla, Marina S. Boukhvalova, Trudy G. Morrison   +5 more
doaj   +1 more source

Cross-Protection Induced by Virus-like Particles Derived from the Influenza B Virus

Biomedicines, 2022
The mismatch between the circulating influenza B virus (IBV) and the vaccine strain contributes to the rapid emergence of IBV infection cases throughout the globe, which necessitates the development of effective vaccines conferring broad protection. Here,
Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Fu-Shi Quan   +5 more
doaj   +1 more source

Advancing usability of an influenza hemagglutinin virus-like particle vaccine expressing a chimeric cytokine

Virology Journal, 2023
Vaccine efficacy of conventional influenza vaccines depend on the antigenic similarity between the selected vaccine strain and annual epidemic strain. Since the influenza virus evolves yearly, a vaccine which is independent from viral antigenic mutation ...
Toshifumi Imagawa, Youta Arasaki, Kenichi Maegawa, Shigeo Sugita, Kuniaki Nerome   +4 more
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Virus-like Particle Vaccines and Platforms for Vaccine Development

Viruses, 2023
Virus-like particles (VLPs) have gained a lot of interest within the past two decades. The use of VLP-based vaccines to protect against three infectious agents—hepatitis B virus, human papillomavirus, and hepatitis E virus—has been approved; they are ...
Milad Kheirvari, Hong Liu, Ebenezer Tumban   +2 more
doaj   +1 more source

The Immunogenicity of Capsid-Like Particle Vaccines in Combination with Different Adjuvants Using Different Routes of Administration

Vaccines, 2021
Capsid-like particle (CLP) displays can be used to enhance the immunogenicity of vaccine antigens, but a better understanding of how CLP vaccines are best formulated and delivered is needed.
Christoph M. Janitzek, Philip H. R. Carlsen, Susan Thrane, Vijansh M. Khanna, Virginie Jakob, Christophe Barnier-Quer, Nicolas Collin, Thor G. Theander, Ali Salanti, Morten A. Nielsen, Adam F. Sander   +10 more
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Expression of dengue virus and Zika virus NS2B-NS3pro constructs alter cellular fatty acids, but co-expression with a Zika virus virus-like particle is detrimental to virus-like particle expression

BMC Research Notes, 2023
Objective Studies have shown that Flavivirus infection remodels the host cell to favour viral replication. In particular, the host cell lipid profile is altered, and it has been proposed that this process alters membrane fluidity to allow wrapping of the
Suwipa Ramphan, Nathamon Yimpring, Chontida Tangsongcharoen, Suthatta Sornprasert, Atitaya Hitakarun, Wannapa Sornjai, Sittiruk Roytrakul, Atikorn Panya, Duncan R. Smith   +8 more
doaj   +1 more source

HIV-1 Virus-like Particle Budding Assay

Bio-Protocol, 2013
Viral replication culminates with the egress of the mature virion from the host cell. This step of the viral life cycle has recently garnered increased attention with the discovery of the cellular restriction factor, Tetherin, which tethers budded ...
Nathan Vande Burgt, Luis Cocka , Paul Bates   +2 more
doaj   +1 more source

Virus-like Particles: Measures and Biological Functions

Viruses, 2022
Virus-like particles resemble infectious virus particles in size, shape, and molecular composition; however, they fail to productively infect host cells.
Tara Bhat, Amy Cao, John Yin
doaj   +1 more source

Identification of Novel Adjuvants for Ebola Virus-Like Particle Vaccine

Vaccines, 2020
Ebola virus disease is a severe disease, often fatal, with a mortality rate of up to 90%. Presently, effective treatment and safe prevention options for Ebola virus disease are not available. Therefore, there is an urgent need to develop control measures
Huapeng Feng, Sumiho Nakatsu, Tiago Jose da Silva Lopes, Masaki Imai, Seiya Yamayoshi, Makoto Yamashita, Tokiko Watanabe, Yoshihiro Kawaoka   +7 more
doaj   +1 more source