Special Issue “Virus-Like Particle Vaccines” [PDF]
Viruses, 2020 Virus-like particles (VLPs) have become a key tool for vaccine developers and manufacturers [...]
Monique Vogel, Martin F. Bachmann
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Expression of dengue virus and Zika virus NS2B-NS3pro constructs alter cellular fatty acids, but co-expression with a Zika virus virus-like particle is detrimental to virus-like particle expression [PDF]
BMC Research Notes, 2023 Objective Studies have shown that Flavivirus infection remodels the host cell to favour viral replication. In particular, the host cell lipid profile is altered, and it has been proposed that this process alters membrane fluidity to allow wrapping of the
Suwipa Ramphan +8 more
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Virus-like particle vaccine protects against 2009 H1N1 pandemic influenza virus in mice. [PDF]
PLoS ONE, 2010 The 2009 influenza pandemic and shortages in vaccine supplies worldwide underscore the need for new approaches to develop more effective vaccines.We generated influenza virus-like particles (VLPs) containing proteins derived from the A/California/04/2009
Fu-Shi Quan +3 more
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Optimization and validation of a virus‐like particle pseudotyped virus neutralization assay for SARS‐CoV‐2 [PDF]
MedCommSpike‐protein‐based pseudotyped viruses were used to evaluate vaccines during the COVID‐19 pandemic. However, they cannot be used to evaluate the envelope (E), membrane (M), and nucleocapsid (N) proteins. The first generation of virus‐like particle (VLP)
Shuo Liu +12 more
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Virus-like particle vaccines: immunology and formulation for clinical translation
Expert Review of Vaccines, 2018 Introduction: Virus-like particle (VLP) vaccines face significant challenges in their translation from laboratory models, to routine clinical administration. While some VLP vaccines thrive and are readily adopted into the vaccination schedule, others are
Braeden Donaldson +4 more
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Advances in virus-like particle-based SARS-CoV-2 vaccines [PDF]
Frontiers in Cellular and Infection MicrobiologyThe Coronavirus Disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has incurred devastating human and economic losses. Vaccination remains the most effective approach for controlling the COVID-19
Xiaoting Hao, Feifei Yuan, Xuan Yao
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Exploring the Effects of Intersubunit Interface Mutations on Virus-Like Particle Structure and Stability. [PDF]
BiochemistryVirus-like particles (VLPs) from bacteriophage MS2 provide a platform to study protein self-assembly and create engineered systems for drug delivery.
Pistono PE +4 more
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Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19
Nature Network Boston, 2021 Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being deployed, but the global need greatly exceeds the supply, and different formulations might be required for specific populations.
B. Ward +18 more
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Mechanical tuning of virus-like particles
Journal of Colloid and Interface Science, 2023 Journal of Colloid and Interface Science ...
Radiom, Milad +8 more
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Vaccines, 2021 SARS-CoV-2 claimed numerous lives and put nations on high alert. The lack of antiviral medications and the small number of approved vaccines, as well as the recurrence of adverse effects, necessitates the development of novel treatment ways to combat ...
Acharya Balkrishna +10 more
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