Results 51 to 60 of about 583,625 (325)

Bioanalytics for Influenza Virus-Like Particle Characterization and Process Monitoring

Frontiers in Bioengineering and Biotechnology, 2022
Virus-like particles (VLPs) are excellent platforms for the development of influenza vaccine candidates. Nonetheless, their characterization is challenging due to VLPs’ unique biophysical and biochemical properties. To cope with such complexity, multiple
Sofia B. Carvalho, Sofia B. Carvalho, Ricardo J. S. Silva, Ricardo J. S. Silva, Marcos F. Q. Sousa, Marcos F. Q. Sousa, Cristina Peixoto, Cristina Peixoto, António Roldão, António Roldão, Manuel J. T. Carrondo, Paula M. Alves, Paula M. Alves   +12 more
doaj   +1 more source

Plant Virus-Like Particle In Situ Vaccine for Intracranial Glioma Immunotherapy

Cancers, 2019
Despite aggressive multi-modality treatment with surgery, radiation and chemotherapies, malignant glioma inevitably recurs and has dismal survival rates.
Amber E. Kerstetter-Fogle, Sourabh Shukla, Chao Wang, V. Beiss, Peggy L. R. Harris, A. Sloan, N. Steinmetz   +6 more
semanticscholar   +1 more source

Virus-like particle vaccines containing F or F and G proteins confer protection against respiratory syncytial virus without pulmonary inflammation in cotton rats

Human Vaccines & Immunotherapeutics, 2017
Vaccine-enhanced disease has been a major obstacle in developing a safe vaccine against respiratory syncytial virus (RSV). This study demonstrates the immunogenicity, efficacy, and safety of virus-like particle (VLP) vaccines containing RSV F (F VLP), G (
Hye Suk Hwang, Ki-Hye Kim, Youri Lee, Young-Tae Lee, Eun-Ju Ko, SooJin Park, Jong Seok Lee, Byung-cheol Lee, Young-Man Kwon, Martin L. Moore, Sang-Moo Kang   +10 more
doaj   +1 more source

A virus-like particle vaccine prevents equine encephalitis virus infection in nonhuman primates

Science Translational Medicine, 2019
A multivalent VLP vaccine protects against aerosol challenge of three lethal encephalitis viruses in mice and nonhuman primates. A triple threat to equine encephalitis viruses There are no approved treatments or vaccines for certain alphaviruses that can
S. Ko, W. Akahata, E. Yang, W. Kong, Crystal W. Burke, S. Honnold, D. Nichols, Yan-Jang S. Huang, G. Schieber, Kevin Carlton, L. DaSilva, V. Traina-Dorge, D. Vanlandingham, Y. Tsybovsky, T. Stephens, U. Baxa, S. Higgs, C. Roy, Pamela J. Glass, J. Mascola, G. Nabel, Srinivas S. Rao   +21 more
semanticscholar   +1 more source

Tomato spotted wilt virus glycoproteins induce the formation of endoplasmic reticulum- and Golgi-derived pleomorphic membrane structures in plant cells [PDF]

, 2008
Tomato spotted wilt virus (TSWV) particles are spherical and enveloped, an uncommon feature among plant infecting viruses. Previous studies have shown that virus particle formation involves the enwrapment of ribonucleoproteins with viral glycoprotein ...
Denecke, J., Foresti, O., Goldbach, R.W., Kormelink, R.J.M., Ribeiro, D.M.O.G., Wellink, J.   +5 more
core   +2 more sources

Effective chikungunya virus-like particle vaccine produced in insect cells. [PDF]

PLoS Neglected Tropical Diseases, 2013
The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the successful
Stefan W Metz, Joy Gardner, Corinne Geertsema, Thuy T Le, Lucas Goh, Just M Vlak, Andreas Suhrbier, Gorben P Pijlman   +7 more
doaj   +1 more source

Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism [PDF]

, 2013
The formation of a protective protein container is an essential step in the life-cycle of most viruses. In the case of single-stranded (ss)RNA viruses, this step occurs in parallel with genome packaging in a co-assembly process.
Bakker, S.E., Barker, A.M., Borodavka, A., Dykeman, Eric, Ford, R.J., Pearson, A.R., Phillips, S.E.V., Ranson, N.A., Stockley, P.G., Tuma, R., Twarock, R.   +10 more
core   +2 more sources

Virus-like particle display of HER2 induces potent anti-cancer responses

Oncoimmunology, 2018
Overexpression of human epidermal growth factor receptor-2 (HER2) occurs in 20–30% of invasive breast cancers. Monoclonal antibody therapy is effective in treating HER2-driven mammary carcinomas, but its utility is limited by high costs, side effects and
A. Palladini, S. Thrane, C. Janitzek, Jessica Pihl, Stine B. Clemmensen, W. A. de Jongh, T. M. Clausen, G. Nicoletti, L. Landuzzi, M. Penichet, Tania Balboni, Marianna L. Ianzano, Veronica Giusti, T. Theander, M. Nielsen, A. Salanti, P. Lollini, P. Nanni, A. Sander   +18 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source