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Minimal system for assembly of SARS-CoV-2 virus like particles
Scientific Reports, 2020 SARS-CoV-2 virus is the causative agent of COVID-19. Here we demonstrate that non-infectious SARS-CoV-2 virus like particles (VLPs) can be assembled by co-expressing the viral proteins S, M and E in mammalian cells.
Heather Swann +7 more
doaj +2 more sources
Recent Progress on the Versatility of Virus-Like Particles
Vaccines, 2020 Virus-like particles (VLPs) are multimeric nanostructures composed of one or more structural proteins of a virus in the absence of genetic material. Having similar morphology to natural viruses but lacking any pathogenicity or infectivity, VLPs have ...
Ciying Qian +10 more
doaj +2 more sources
Virus like particles as a platform for cancer vaccine development [PDF]
PeerJ, 2017 Cancers have killed millions of people in human history and are still posing a serious health problem worldwide. Therefore, there is an urgent need for developing preventive and therapeutic cancer vaccines.
Hui Kian Ong, Wen Siang Tan, Kok Lian Ho
doaj +3 more sources
Virus-Like Particles as an Immunogenic Platform for Cancer Vaccines
Viruses, 2020 Virus-like particles (VLP) spontaneously assemble from viral structural proteins. They are naturally biocompatible and non-infectious. VLP can serve as a platform for many potential vaccine epitopes, display them in a dense repeating array, and elicit ...
Jerri C. Caldeira +3 more
doaj +2 more sources
Journal of Nanobiotechnology, 2021 Virus-like particles (VLPs) are virus-derived structures made up of one or more different molecules with the ability to self-assemble, mimicking the form and size of a virus particle but lacking the genetic material so they are not capable of infecting ...
Saghi Nooraei +6 more
semanticscholar +1 more source
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins
Cell, 2022 Summary Methods to deliver gene editing agents in vivo as ribonucleoproteins could offer safety advantages over nucleic acid delivery approaches.
Samagya Banskota +13 more
semanticscholar +1 more source
Platforms, advances, and technical challenges in virus-like particles-based vaccines
Frontiers in Immunology, 2023 Viral infectious diseases threaten human health and global stability. Several vaccine platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based vaccines have been developed to counter these viral infectious diseases.
Reeshu Gupta +6 more
semanticscholar +1 more source
Frontiers in Microbiology, 2022 Virus-like particles (VLPs) are nanostructures that possess diverse applications in therapeutics, immunization, and diagnostics. With the recent advancements in biomedical engineering technologies, commercially available VLP-based vaccines are being ...
Hasnat Tariq +4 more
semanticscholar +1 more source
Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles
bioRxiv, 2021 Newly evolved SARS-CoV-2 variants are driving ongoing outbreaks of COVID-19 around the world. Efforts to determine why these viral variants have improved fitness are limited to mutations in the viral spike (S) protein and viral entry steps using non-SARS-
A. Syed +10 more
semanticscholar +1 more source
Virus-like Particles: Fundamentals and Biomedical Applications
International Journal of Molecular Sciences, 2022 Nanotechnology is a fast-evolving field focused on fabricating nanoscale objects for industrial, cosmetic, and therapeutic applications. Virus-like particles (VLPs) are self-assembled nanoparticles whose intrinsic properties, such as heterogeneity, and ...
Jorge L. Mejía-Méndez +4 more
semanticscholar +1 more source