Results 11 to 20 of about 203,768 (257)
Programmable Polymorphism of a Virus-Like Particle [PDF]
Communications Materials, 2021 Abstract Virus-like particles (VLPs) have significant potential as both artificial vaccines and drug delivery systems. The ability to control their size has wide ranging utility, but achieving such controlled polymorphism using a single protein subunit is challenging as it requires altering VLP geometry.
Artur P. Biela +4 more
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Characterization of Chikungunya Virus-Like Particles [PDF]
PLoS ONE, 2014 El virus Chikungunya (CHIKV) se está convirtiendo en una preocupación mundial debido al creciente número de brotes en todo el mundo y la ausencia de cualquier vacuna o tratamiento específico contra el CHIKV. Las partículas similares a virus (VLP) son proteínas multiestructuradas que imitan la organización y conformación de los virus nativos, pero ...
Nitchakarn Noranate +5 more
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Virus-like particles in vaccine development
Expert Review of Vaccines, 2010 Virus-like particles (VLPs) are multiprotein structures that mimic the organization and conformation of authentic native viruses but lack the viral genome, potentially yielding safer and cheaper vaccine candidates. A handful of prophylactic VLP-based vaccines is currently commercialized worldwide: GlaxoSmithKline's Engerix (hepatitis B virus) and ...
Antonio Roldāo +2 more
exaly +3 more sources
Colloidal Crystallization of Virus-Like Particles with Polycations. [PDF]
SmallAbstract Virus‐like particles (VLPs) are protein nanocages capable of encapsulating or attaching guest molecules. Unlike viruses, they do not replicate in cells, making them promising candidates for advanced biomaterial design, particularly for biomedical applications such as drug delivery. However, the mechanisms
Tran B, Keys TG, Radiom M, Salentinig S.
europepmc +4 more sources
Production of virus-like particles for vaccines
New Biotechnology, 2017 Virus-like particles (VLPs) are nanostructures that resemble the structures of viruses. They are composed of one or more structural proteins that can be arranged in several layers and can also contain a lipid outer envelope. VLPs trigger a high humoral and cellular immune response due to their repetitive structures. A key factor regarding VLP safety is
Javier Fuenmayor, Laura Cervera
exaly +3 more sources
Platelet-like particles released from Ebola virus-infected megakaryocytic cells behave like virus-like particles. [PDF]
PLoS PathogEbola virus (EBOV) is likely a zoonotic and re-emerging virus that causes severe outbreaks of Ebola virus disease. The virus spreads to various tissues during the late stage of infection and has been detected in immune-privileged sites of survivors ...
Kuroda M, Halfmann PJ.
europepmc +2 more sources
Size-selective downstream processing of virus particles and non-enveloped virus-like particles
Frontiers in Bioengineering and Biotechnology, 2023 Non-enveloped virus-like particles (VLPs) are versatile protein nanoparticles with great potential for biopharmaceutical applications. However, conventional protein downstream processing (DSP) and platform processes are often not easily applicable due to
Nils Hillebrandt, Jürgen Hubbuch
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Zika virus like particles elicit protective antibodies in mice. [PDF]
PLoS Neglected Tropical Diseases, 2018 Mosquito-borne Zika virus (ZIKV) typically causes a mild and self-limiting illness known as Zika fever. Since its recent emergence in 2014 in the American continent, ZIKV infection during pregnancy has been closely associated with a wide range of ...
Mauricio A Salvo +4 more
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Production of mosquito cell-derived Zika virus-like particles using BacMos system
Journal of Medical Sciences, 2021 Background: Zika virus (ZIKV) is a mosquito-borne flavivirus which has been conclusively linked to Guillain-Barré syndrome and microcephaly. The worldwide emergence of ZIKV has greatly increased the demand for vaccines that reduce or prevent disease ...
Hui-Tsu Lin +2 more
doaj +1 more source
Preparation of Class Y Immunoglobulins that Neutralize the Marburg Virus
Проблемы особо опасных инфекций, 2021 The aim was to study the possibility of inducing Marburg-neutralizing chicken antibodies (MARV) using various immunogens.Materials and methods. Recombinant vaccinia virus expressing the surface glycoprotein (GP) transgene MARV of Musoke strain and ...
O. A. Polezhaeva +7 more
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