Results 221 to 230 of about 731,035 (329)

Production of virus-like particles for vaccines

New Biotechnology, 2017
Javier Fuenmayor, F. Gòdia, L. Cervera
semanticscholar   +1 more source

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

In vitro characterization of cellular responses elicited by endosomal TLR agonists encapsulated in Qβ virus-like particles. [PDF]

BMC Immunol
Hasibuzzaman MM, Ibarra B, Khan IN, Meagher TC, Lemke-Miltner CD, Weiner GJ, Simons AL.   +6 more
europepmc   +1 more source

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, EarlyView.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

Modular Virus-like Particles for Antigen Presentation: Comparing Genetic Fusion and Click-Chemistry for Purification. [PDF]

Int J Mol Sci
Balbierer K, Jenzelewski V, Herrmann FC, Piontek M, Jose J.   +4 more
europepmc   +1 more source

Physalis Mottle Virus-Like Particles as Nanocarriers for Imaging Reagents and Drugs.

Biomacromolecules, 2017
Hema Masarapu, Bindi K Patel, Paul L. Chariou, He Hu, Neetu M. Gulati, Bradley L. Carpenter, R. Ghiladi, Sourabh Shukla, N. Steinmetz   +8 more
semanticscholar   +1 more source

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Advanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng, Metoboroghene Mowoe, Wenqing Hou, Daniel W. Hagey, Koshi Imami, Samir EL Andaloussi   +5 more
wiley   +1 more source

Protection Against Toxoplasma gondii Lethal ME49 Challenge Induced by Influenza Virus-like Particles Containing Dense Granule Protein 14. [PDF]

Pharmaceutics
Mao J, Kang HJ, Eom GD, Heo SI, Nam H, Lee JH, Park KH, Lee MS, Kim SS, Quan FS.   +9 more
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Muscle-specific gene editing therapy via mammalian fusogen-directed virus-like particles. [PDF]

Nat Commun
Zhou SK, Luo JT, Chen YF, Lu ZD, Jian QH, Jiang SQ, Li J, Zhang XQ, Tan XY, Yang XZ, Xu CF, Wang J.   +11 more
europepmc   +1 more source