Results 71 to 80 of about 731,035 (329)

Special Issue “Virus-Like Particle Vaccines” [PDF]

Viruses, 2020
Virus-like particles (VLPs) have become a key tool for vaccine developers and manufacturers [...]
Monique Vogel, Martin F. Bachmann
openaire   +4 more sources

Virus‐like particles for vaccination against cancer

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2019
Active immunotherapy of cancer aims to treat the disease by inducing effective cellular and humoral immune responses. Virus‐like particle‐based vaccines have evolved dramatically over the last few decades, greatly reducing morbidity and mortality of ...
Mona O. Mohsen, D. Speiser, A. Knuth, M. Bachmann   +3 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Virus-like particles—universal molecular toolboxes

Current Opinion in Biotechnology, 2007
Virus-like particles (VLPs) are highly organised spheres that self-assemble from virus-derived structural antigens. These stable and versatile subviral particles possess excellent adjuvant properties capable of inducing innate and cognate immune responses.
Ludwig, Christine, Wagner, Ralf
openaire   +2 more sources

Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins

Nature Communications, 2019
Intestinal and free-living protozoa, such as Giardia lamblia, express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host’s intestine.
M. C. Serradell, Lucía L. Rupil, R. Martino, C. Prucca, P. G. Carranza, Alicia Saura, Elmer A Fernández, P. Gargantini, Albano H. Tenaglia, J. P. Petiti, R. R. Tonelli, Nicolás M. Reinoso-Vizcaíno, J. Echenique, L. Berod, E. Piaggio, B. Bellier, T. Sparwasser, D. Klatzmann, H. Luján   +18 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Virus-inspired biogenic delivery system for advancing cancer therapy

Biomedical Technology
Virus-inspired particles have been utilized in various applications, including vaccination, gene therapy, drug therapy, and diagnostics. Biogenic delivery systems imitating the natural structure of viruses are regarded as innovative nanoplatforms used to
Di Sun, Hao Liang, Qianwen Mu, Chengchao Chu, Gang Liu, Chao Liu   +5 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Mechanical tuning of virus-like particles

Journal of Colloid and Interface Science, 2023
Journal of Colloid and Interface Science ...
Radiom, Milad, Keys, Tim, Turgay, Yagmur, Ali, Ahmed, Preet, Swapan, Chesnov, Serge, Lutz-Bueno, Viviane, Slack, Emma, Mezzenga, Raffaele   +8 more
openaire   +3 more sources

Preclinical Development of a Novel Zika Virus-like Particle Vaccine in Combination with Tetravalent Dengue Virus-like Particle Vaccines

Vaccines
Declared as a Public Health Emergency in 2016 by the World Health Organization (WHO), the Zika virus (ZIKV) continues to cause outbreaks that are linked to increased neurological complications.
Dominik A. Rothen, Sudip Kumar Dutta, Pascal S. Krenger, Alessandro Pardini, Anne-Cathrine S. Vogt, Romano Josi, Ilva Lieknina, Albert D. M. E. Osterhaus, Mona O. Mohsen, Monique Vogel, Byron Martina, Kaspars Tars, Martin F. Bachmann   +12 more
doaj   +1 more source