Results 101 to 110 of about 2,979,740 (254)

A modelling paradigm for RNA virus assembly [PDF]

, 2018
Virus assembly, a key stage in any viral life cycle, had long been considered to be primarily driven by protein–protein interactions and nonspecific interactions between genomic RNA and capsid protein.
Twarock, Reidun, Twarock, R, Stockley, Peter G., Dykeman, Eric Charles, Bingham, RJ, Bingham, Richard John, Dykeman, EC, Stockley, PG   +7 more
core   +1 more source

The Morphology and Assembly of Respiratory Syncytial Virus Revealed by Cryo-Electron Tomography

Viruses, 2018
Human respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract disease in young children. With repeat infections throughout life, it can also cause substantial disease in the elderly and in adults with compromised cardiac ...
Zunlong Ke, Rebecca S. Dillard, Tatiana Chirkova, Fredrick Leon, Christopher C. Stobart, Cheri M. Hampton, Joshua D. Strauss, Devi Rajan, Christina A. Rostad, Jeannette V. Taylor, Hong Yi, Raven Shah, Mengtian Jin, Tina V. Hartert, R. Stokes Peebles, Barney S. Graham, Martin L. Moore, Larry J. Anderson, Elizabeth R. Wright   +18 more
doaj   +1 more source

An Engineered Thio‐Amino Polymer Achieves Potent, Safe, and Broad Cell Type Delivery in the Lung Mapped by Spatial Transcriptomics

Advanced Materials, EarlyView.
Synthesis and screening of a polymer library produced a versatile and inhalable mRNA vehicle for the lungs (P81). Compared to a published LNP, P81 provides increased delivery efficacy, achieving widespread expression in broad cell types, with no toxicity.
Pramodkumar EK, Younghun Jung, Elex S. Rose, Jae Yeon Joo, James R. Rose, José A. F. Assumpção, Hyeyoon Jeong, Lorena C. S. Chaves, Blake Andrew Miller, João Paulo Pera Mendes, Hannah E. Peck, Charmy J. Patel, Loren E. Sasser, Heather Pathak, Varun V. Mosur, Jaehyeon Hwang, Guilherme de Oliveira Lopes, Merrilee Thoresen, Santiago Cornejo, Peres Badial, Alicia Olivier, Amelia R. Woolums, Samuele Stazzoni, Noemi Manganaro, Eleonora Nencini, Giulio Pierleoni, Emanuele Andreano, Rino Rappuoli, Nichole Orr‐Burks, Sarah R. Hosking, Nicholas S. Heaton, Eric R. Lafontaine, Robert J. Hogan, Francois Villinger, Daryll Vanover, Chiara Zurla, Philip J. Santangelo   +36 more
wiley   +1 more source

Structural analysis of the roles of influenza A virus membrane-associated proteins in assembly and morphology

, 2015
The assembly of influenza A virus at the plasma membrane of infected cells leads to release of enveloped virions that are typically round in tissue culture-adapted strains but filamentous in strains isolated from patients.
Kummer, S., Briggs, J., Oliver Schraidt, Chlanda, Petr, Heike Oberwinkler, Simone Prinz, Prinz, Simone, Schraidt, Oliver, Oberwinkler, Heike, Susann Kummer, Kummer, Susann, John A. G. Briggs, Schraidt, O., Hans-Georg Kräusslich, Riches, J., Kräusslich, Hans-Georg, Prinz, S., Riches, James, Oberwinkler, H., Krausslich, H., Petr Chlanda, Chlanda, P., Briggs, John A.G., James Riches   +23 more
core   +1 more source

Life‐Like Ferrous Oxide Microspheres from Kombucha

Advanced Materials Interfaces, EarlyView.
Kombucha bacterial cellulose, sodium alginate, and ferrous nitrate self‐assemble into membrane‐enclosed iron oxide microspheres. These microspheres bud daughter vesicles, sustain 24‐h electrochemical oscillations, and filter theta‐band signals.
Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky   +2 more
wiley   +1 more source

The Effects of Viral Structural Proteins on Acidic Phospholipids in Host Membranes

Viruses
Enveloped viruses rely on host membranes for trafficking and assembly. A substantial body of literature published over the years supports the involvement of cellular membrane lipids in the enveloped virus assembly processes.
Ricardo de Souza Cardoso, Akira Ono
doaj   +1 more source

Interface Dynamics in Biomolecular Condensates by High‐Speed AFM

Advanced Materials Interfaces, EarlyView.
High‐speed atomic force microscopy provides nanoscale structural dynamics at the liquid interface of biomolecular condensates, key elements in several cellular pathways. By addressing the challenges of low surface tension and condensate‐induced instabilities, we achieve nanometer spatial and sub‐second temporal resolution, revealing structural ...
Andreas Santamaria, Nessim Louafi, Isabelle Alakiki, Stephanie Hutin, Chloe Zubieta, Pierre‐Emmanuel Milhiet, Luca Costa   +6 more
wiley   +1 more source

Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly.: HCV core protein cleavage by SPP and viral assembly [PDF]

, 2006
International audienceHepatitis C virus (HCV) core protein, expressed with a Semliki Forest virus replicon, self-assembles into HCV-like particles (HCV-LP) at the endoplasmic reticulum (ER) membrane, providing an opportunity to study HCV assembly and ...
Trassard, Sylvie, Ait-Goughoulte, Malika, Patient, Romuald, Brand, Denys, Hourioux, Christophe, Roingeard, Philippe, Christophe Hourioux, Denys Br, Hal Id Inserm, Romuald Patient, Malika Ait-goughoulte   +10 more
core   +1 more source

Virus assembly, allostery, and antivirals [PDF]

, 2010
Assembly of virus capsids and surface proteins must be regulated to ensure that the resulting complex is an infectious virion. In this review, we examine assembly of virus capsids, focusing on hepatitis B virus and bacteriophage MS2, and formation of ...
Zlotnick, Adam, Mukhopadhyay, Suchetana
core   +1 more source

Structure of a new capsid form and comparison with A-, B-, and C-capsids clarify herpesvirus assembly

Journal of Virology
Three capsid types have been recognized from the nuclei of herpesvirus-infected cells: empty A-capsids, scaffolding-containing B-capsids, and DNA-filled C-capsids.
Alexander Stevens, Saarang Kashyap, Ethan Crofut, Ana Lucia Alvarez-Cabrera, Jonathan Jih, Yun-Tao Liu, Z. Hong Zhou   +6 more
doaj   +1 more source