Results 161 to 170 of about 2,522,803 (297)

Vemurafenib Inhibits Enterovirus A71 Genome Replication and Virus Assembly. [PDF]

Pharmaceuticals (Basel), 2022
Hu B, Chik KK, Chan JF, Cai JP, Cao H, Tsang JO, Zou Z, Hung YP, Tang K, Jia L, Luo C, Yin F, Ye ZW, Chu H, Yeung ML, Yuan S.   +15 more
europepmc   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Structure of SARS-CoV-2 membrane protein essential for virus assembly. [PDF]

Nat Commun, 2022
Zhang Z, Nomura N, Muramoto Y, Ekimoto T, Uemura T, Liu K, Yui M, Kono N, Aoki J, Ikeguchi M, Noda T, Iwata S, Ohto U, Shimizu T.   +13 more
europepmc   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

A physical model for M1-mediated influenza A virus assembly. [PDF]

Biophys J
Peukes J, Dmitrieff S, Nédélec FJ, Briggs JAG.   +3 more
europepmc   +2 more sources

Role of NS2 specific RNA binding and phosphorylation in liquid-liquid phase separation and virus assembly. [PDF]

Nucleic Acids Res, 2022
Rahman SK, Ampah KK, Roy P.
europepmc   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Identification and characterization of key residues in Zika virus envelope protein for virus assembly and entry. [PDF]

Emerg Microbes Infect, 2022
Ma X, Yuan Z, Yi Z.
europepmc   +1 more source

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Direct lipid interactions control SARS-CoV-2 M protein conformational dynamics and virus assembly. [PDF]

Nat Commun
Dutta M, Dolan KA, Amiar S, Bass EJ, Sultana R, Braet SM, Cárdenas-Martínez KJ, Sirohi D, Hicklin IK, Kuhn RJ, Anand GS, Voth GA, Brohawn SG, Stahelin RV.   +13 more
europepmc   +1 more source