Results 161 to 170 of about 262,059 (309)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Assessing the de novo assemblers: a metaviromic study of apple and first report of citrus concave gum-associated virus, apple rubbery wood virus 1 and 2 infecting apple in India

BMC Genomics
Background The choice of de novo assembler for high-throughput sequencing (HTS) data remains a pivotal factor in the HTS-based discovery of viral pathogens.
Zainul A. Khan, Susheel Kumar Sharma, Nitika Gupta, Damini Diksha, Pooja Thapa, Mailem Yazing Shimray, Malyaj R. Prajapati, Sajad U. Nabi, Santosh Watpade, Mahendra K. Verma, Virendra K. Baranwal   +10 more
doaj   +1 more source

Identification and characterization of key residues in Zika virus envelope protein for virus assembly and entry. [PDF]

Emerg Microbes Infect, 2022
Ma X, Yuan Z, Yi Z.
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

A physical model for M1-mediated influenza A virus assembly. [PDF]

Biophys J
Peukes J, Dmitrieff S, Nédélec FJ, Briggs JAG.   +3 more
europepmc   +2 more sources

Role of NS2 specific RNA binding and phosphorylation in liquid-liquid phase separation and virus assembly. [PDF]

Nucleic Acids Res, 2022
Rahman SK, Ampah KK, Roy P.
europepmc   +1 more source

In vitro assembly of the feline immunodeficiency virus Gag polyprotein

, 2010
The retroviral Gag protein is the only viral product that is necessary for the assembly of virions in mammalian cells. We have established an in vitro assembly system to study the assembly properties of purified feline immunodeficiency virus (FIV) Gag ...
Affranchino, José L., González, Silvia A.   +1 more
core  

Influenza virus assembly

, 2015
Influenza A Viren besitzen ein segmentiertes, einzelsträngiges RNA-Genom, welches in Form viraler Ribonukleoprotein (vRNP)-Komplexe verpackt ist. Während das virale Genom im Zellkern repliziert wird, finden Assemblierung und Knospung reifer Viruspartikel an der apikalen Plasmamembran statt.
openaire   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Interaction between long and short particles of tobacco rattle virus

, 1972
Tobacco rattle virus is a rod-shaped multiparticle virus.Short particles alone are not infectious, long ones are but give rise to the formation of incomplete virus. Mixtures of long and short particles induce the formation of complete virus.
Huttinga, H.
core