Results 181 to 190 of about 2,522,803 (297)

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Hepatitis B Virus Assembly: Cryo-Electron Microscopy Reveals Structure of the Surface Antigen. [PDF]

MedComm (2020)
Li G, Cui J, Nie J.
europepmc   +1 more source

Machine-learning a virus assembly fitness landscape. [PDF]

PLoS One, 2021
Dechant PP, He YH.
europepmc   +1 more source

A Bright Ratiometric Dipyrene Probe for Functional Imaging of Condensate Microenvironments in Living Cells

Advanced Science, EarlyView.
Ratiometric dipyrene imaging resolves monomer (M) and excimer (E) channels and computes pixel‐wise E/M maps within biomolecular condensates, yielding physicochemical fingerprints shaped by coupled polarity‐related solvation and microviscosity. These spatial fingerprints enable quantitative phenotyping of cellular states, exemplified by separation of ...
Koki Matsumoto, Sora Kitai, Yoshio Nishiyama, Shogo Amemori, Kei Makiyama, Dini Kurnia Ikliptikawati, Kentaro Ohira, Yuta Kozuka, Maho Tobita, Shih‐Cheng Chen, Chien‐Hung Yu, Wei‐Min Liu, De‐Chen Lin, Motohiro Mizuno, Kazuma Ogawa, Koichi Ogami, Kenji Takahashi, Hiroshi I. Suzuki, Richard W. Wong, Takahiro Soeta, Masaharu Hazawa   +20 more
wiley   +1 more source

Spatiotemporal coordination of reovirus peripheral core replication to perinuclear whole virus assembly. [PDF]

PLoS Pathog
Kniert J, Terino D, Eaton HE, Lin QF, Wu SY, Strickfaden H, Shmulevitz M.   +6 more
europepmc   +1 more source

Atomic view of the HIV-1 matrix lattice; implications on virus assembly and envelope incorporation. [PDF]

Proc Natl Acad Sci U S A, 2022
Samal AB, Green TJ, Saad JS.
europepmc   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly. [PDF]

PLoS Pathog
Butt BG, Fischer D, Rep AR, Schauflinger M, Read C, Böck T, Hirner M, Wienen F, Graham SC, von Einem J.   +9 more
europepmc   +2 more sources

From disorder to icosahedral symmetry: How conformation-switching subunits enable RNA virus assembly. [PDF]

Sci Adv
Li S, Tresset G, Zandi R.
europepmc   +1 more source

The Small GTPase Rab14 Regulates the Trafficking of Ceramide from Endoplasmic Reticulum to Golgi Apparatus and Facilitates Classical Swine Fever Virus Assembly. [PDF]

J Virol, 2023
Liu YY, Bai JS, Liu CC, Zhou JF, Chen J, Cheng Y, Zhou B.   +6 more
europepmc   +1 more source