Results 201 to 210 of about 3,262,736 (331)

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly. [PDF]

PLoS Pathog
Butt BG, Fischer D, Rep AR, Schauflinger M, Read C, Böck T, Hirner M, Wienen F, Graham SC, von Einem J.   +9 more
europepmc   +2 more sources

From disorder to icosahedral symmetry: How conformation-switching subunits enable RNA virus assembly. [PDF]

Sci Adv
Li S, Tresset G, Zandi R.
europepmc   +1 more source

Atomic view of the HIV-1 matrix lattice; implications on virus assembly and envelope incorporation. [PDF]

Proc Natl Acad Sci U S A, 2022
Samal AB, Green TJ, Saad JS.
europepmc   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Nipah virus matrix protein uses cortical actin to stabilize the virus assembly sites and promote budding. [PDF]

Sci Adv
Wang J, Kliemke V, Zhang M, Liu J, Matta GL, Wang Q, Luo Y, Liu G, Liu Q.   +8 more
europepmc   +1 more source

Structures of a large prolate virus capsid in unexpanded and expanded states generate insights into the icosahedral virus assembly. [PDF]

Proc Natl Acad Sci U S A, 2022
Fang Q, Tang WC, Fokine A, Mahalingam M, Shao Q, Rossmann MG, Rao VB.   +6 more
europepmc   +1 more source

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.

Cell, 2009
Youngsik Cho, Sreerupa Challa, D. Moquin, Ryan M. J. Genga, T. D. Ray, Melissa J. Guildford, F. Chan   +6 more
semanticscholar   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Rational design of self-assembled RNA nanostructures for HIV-1 virus assembly blockade. [PDF]

Nucleic Acids Res, 2022
Qu N, Ying Y, Qin J, Chen AK.
europepmc   +1 more source