Results 71 to 80 of about 3,649,227 (295)

Comparison of the Proteome of Huh7 Cells Transfected with Hepatitis B Virus Subgenotype A1, with or without G1862T

Current Issues in Molecular Biology
HBeAg is a non-structural, secreted protein of hepatitis B virus (HBV). Its p25 precursor is post-translationally modified in the endoplasmic reticulum.
Kiyasha Padarath, Aurélie Deroubaix, Previn Naicker, Stoyan Stoychev, Anna Kramvis   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Key Positions of HIV-1 Env and Signatures of Vaccine Efficacy Show Gradual Reduction of Population Founder Effects at the Clade and Regional Levels

mBio, 2020
HIV-1 group M was transmitted to humans nearly one century ago. The virus has since evolved to form distinct clades, which spread to different regions of the world.
Changze Han, Jacklyn Johnson, Rentian Dong, Raghavendranath Kandula, Alexa Kort, Maria Wong, Tianbao Yang, Patrick J. Breheny, Grant D. Brown, Hillel Haim   +9 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mycoviral diversity and characteristics of a negative-stranded RNA virus LeNSRV1 in the edible mushroom Lentinula edodes.

Virology, 2020
Bioinformatics and RT-PCR analysis of RNA from four Lentinula edodes samples identified 22 different virus-like contigs comprising 15 novel and 3 previously reported viruses.
M. Guo, Guiyu Shen, Jinjie Wang, Mingjie Liu, Y. Bian, Zhang Xu   +5 more
semanticscholar   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

DIVERSITY OF HEPATITIS C VIRUS

The Professional Medical Journal, 2018
Objective: (1)To understand the diversity in HCV glycoprotein E1 and E2sequences at different stages of infection. (2) Method widely used in evolutionary studies of HIV,as a new gold standard in HCV research.Setting: Department of Biochemistry Sir Syed Institutest of Medical Sciences Karachi. Period. 1 Jan 2012 to 31 Dec 2012.
Hamid Mahmood, Nasir Zulfiqar, Sitara Hassan, Ammara Waqar, Naeem Shahzad, Irfan Faroqui   +5 more
openaire   +2 more sources

Relatives of rubella virus in diverse mammals

Nature, 2020
(Uploaded by Plazi for the Bat Literature Project) Since 1814, when rubella was first described, the origins of the disease and its causative agent, rubella virus (Matonaviridae: Rubivirus), have remained unclear1. Here we describe ruhugu virus and rustrela virus in Africa and Europe, respectively, which are, to our knowledge, the first known relatives
Andrew J. Bennett, Adrian C. Paskey, Arnt Ebinger, Florian Pfaff, Grit Priemer, Dirk Höper, Angele Breithaupt, Elisa Heuser, Rainer G. Ulrich, Jens H. Kuhn, Kimberly A. Bishop-Lilly, Martin Beer, Tony L. Goldberg   +12 more
openaire   +3 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Virome Characterization of a Collection of S. sclerotiorum from Australia

Frontiers in Microbiology, 2018
Sclerotinia sclerotiorum is a devastating plant pathogen that attacks numerous economically important broad acre and vegetable crops worldwide. Mycoviruses are widespread viruses that infect fungi, including S. sclerotiorum.
Fan Mu, Fan Mu, Jiatao Xie, Jiatao Xie, Shufen Cheng, Shufen Cheng, Ming Pei You, Martin J. Barbetti, Jichun Jia, Jichun Jia, Qianqian Wang, Qianqian Wang, Jiasen Cheng, Jiasen Cheng, Yanping Fu, Tao Chen, Daohong Jiang, Daohong Jiang   +17 more
doaj   +1 more source