Results 1 to 10 of about 595,205 (256)

Insilico targeting of virus entry facilitator NRP1 to block SARS-CoV2 entry [PDF]

PLoS ONE
The entry and infectivity of a virus are determined by its interaction with the host. SARS-CoV-2, the virus responsible for COVID-19, utilizes the spike (S) protein to attach to and enter host cells.
Nousheen Bibi, Maleeha Shah, Shahzad Khan, Muhammad Shahzad Chohan, Mohammad Amjad Kamal   +4 more
doaj   +3 more sources

Assembly and architecture of the EBV B cell entry triggering complex. [PDF]

, 2014
Epstein-Barr Virus (EBV) is an enveloped double-stranded DNA virus of the gammaherpesvirinae sub-family that predominantly infects humans through epithelial cells and B cells.
Chen, Jia, Hu, Yao Xiong, Jardetzky, Theodore S, Jiang, Jiansen, Jiang, Wei, Longnecker, Richard, Mellins, Elizabeth D, Möhl, Britta S, Rowe, Cynthia L, Sathiyamoorthy, Karthik, Zhou, Z Hong   +10 more
core   +24 more sources

The Immunomodulatory CEA Cell Adhesion Molecule 6 (CEACAM6/CD66c) Is a Protein Receptor for the Influenza A Virus

Viruses, 2021
To establish a productive infection in host cells, viruses often use one or multiple host membrane glycoproteins as their receptors. For Influenza A virus (IAV) such a glycoprotein receptor has not been described, to date.
Shah Kamranur Rahman, Mairaj Ahmed Ansari, Pratibha Gaur, Imtiyaz Ahmad, Chandrani Chakravarty, Dileep Kumar Verma, Anshika Sharma, Sanjay Chhibber, Naila Nehal, Dagmar Wirth, Sunil K. Lal   +10 more
doaj   +1 more source

Dynamics of SARS-CoV-2 Spike Proteins in Cell Entry: Control Elements in the Amino-Terminal Domains

mBio, 2021
Selective pressures drive adaptive changes in the coronavirus spike proteins directing virus-cell entry. These changes are concentrated in the amino-terminal domains (NTDs) and the receptor-binding domains (RBDs) of complex modular spike protein trimers.
Enya Qing, Tom Kicmal, Binod Kumar, Grant M. Hawkins, Emily Timm, Stanley Perlman, Tom Gallagher   +6 more
doaj   +1 more source

Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry. [PDF]

PLoS Pathogens, 2015
HIV-1 enters target cells by virtue of envelope glycoprotein trimers that are incorporated at low density in the viral membrane. How many trimers are required to interact with target cell receptors to mediate virus entry, the HIV entry stoichiometry ...
Oliver F Brandenberg, Carsten Magnus, Peter Rusert, Roland R Regoes, Alexandra Trkola   +4 more
doaj   +1 more source

Membrane Sphingomyelin in Host Cells Is Essential for Nucleocapsid Penetration into the Cytoplasm after Hemifusion during Rubella Virus Entry

mBio, 2022
The lipid composition of the host cell membrane is one of the key determinants of the entry of enveloped viruses into cells. To elucidate the detailed mechanisms behind the cell entry of rubella virus (RuV), one of the enveloped viruses, we searched for ...
Yoshio Mori, Masafumi Sakata, Shota Sakai, Toru Okamoto, Yuichiro Nakatsu, Shuhei Taguwa, Noriyuki Otsuki, Yusuke Maeda, Kentaro Hanada, Yoshiharu Matsuura, Makoto Takeda   +10 more
doaj   +1 more source

Heparan Sulfate Binding Cationic Peptides Restrict SARS-CoV-2 Entry

Pathogens, 2021
A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. While the world is striving for a treatment modality against SARS-CoV-2, our understanding about the virus entry mechanisms may help to design entry ...
Rahul K. Suryawanshi, Chandrashekhar D. Patil, Raghuram Koganti, Sudhanshu Kumar Singh, Joshua M. Ames, Deepak Shukla   +5 more
doaj   +1 more source

A disintegrin and metalloproteinase domain 9 facilitates SARS-CoV-2 entry into cells with low ACE2 expression

Microbiology Spectrum, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the Coronavirus disease-19 (COVID-19) pandemic, utilizes angiotensin-converting enzyme 2 (ACE2) as a receptor for virus infection.
Ivonne Melano, Wei-Chung Cheng, Li-Lan Kuo, Yuag-Meng Liu, Yu Chi Chou, Mien-Chie Hung, Michael M. C. Lai, Yuh-Pyng Sher, Wen-Chi Su   +8 more
doaj   +1 more source

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells [PDF]

, 2018
Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus.
A Milewska, A Pratelli, A Quan, Aleksandra Milewska, AM Zaki, Artur Szczepanski, B Hernaez, B Jancekova, BA Mainou, BJ Dille, C Burkard, C Kooi, C Liu, C Liu, D Dutta, DM Blau, E Dietzel, E Girard, E Hamme Van, EJ Bowman, F Samson, G Preta, GA Wudiri, GM Li, GR Ares, H Imhoff, H Lin, H Wang, IC Huang, IM Mackay, J Li, J Schindelin, J Somsel Rodman, JA Mitchell, JK Millet, JL Wang, JP Lim, JR Henley, Judy A. Mitchell, K Erles, K Erles, K Owczarek, K Shirato, K Shirato, Katarzyna Owczarek, Krzysztof Pyrc, KS Choi, L Kleist von, L Pelkmans, LH Wang, LJ Reed, M Marsh, MG Hemida, MJ Geisow, MJ Vincent, O Achour, O Heikkila, P Duckert, P Eifart, P Oh, Q Xu, R Nomura, S Bertram, S Bolte, S Gierer, S Matsuyama, SL Priestnall, TA Hill, VC Chu, X Ren, Y Inoue, Y Phonphok, Z Qian, Z Qinfen, Zbigniew Baster, Zenon Rajfur   +75 more
core   +8 more sources

Encephalomyocarditis Virus Entry Unveiled

mBio, 2019
Picornaviruses are a widespread group of pathogens that can cause diverse pathologies. Pathogenesis is thought to be driven by the tissue-specific tropisms displayed by these viruses.
Sara Cherry
doaj   +1 more source